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UniProtKB - Q5RGW1 (Q5RGW1_DANRE)
Protein
Submitted name:
Plexin C1
Gene
plxnc1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- semaphorin receptor activity Source: GO_Central
GO - Biological processi
- negative regulation of cell adhesion Source: GO_Central
- positive regulation of axonogenesis Source: GO_Central
- regulation of cell migration Source: GO_Central
- regulation of cell shape Source: GO_Central
- regulation of GTPase activity Source: ZFIN
- semaphorin-plexin signaling pathway involved in axon guidance Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Plexin C1Imported |
Gene namesi | Name:plxnc1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-1620, plxnc1 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- semaphorin receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 430 – 451 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PaxDbi | Q5RGW1 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000015278, Expressed in granulocyte and 21 other tissues |
ExpressionAtlasi | Q5RGW1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 91 | SemaInterPro annotationAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the plexin family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT01020000230384 |
HOGENOMi | CLU_004205_0_0_1 |
OMAi | LFHGENK |
PhylomeDBi | Q5RGW1 |
Family and domain databases
Gene3Di | 1.10.506.10, 1 hit 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR002909, IPT_dom IPR031148, Plexin IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 2 hits |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01833, TIG, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5RGW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SDLQPLSVVF KSSSMSSVAA VRNGSWIVLF MGNSDGQLIK LVLDENYTPS
60 70 80 90 100
CPTVLYKSDD ERAVFPRMHF DPVDSKYIYI ALRKQIRRVS VVRCAKYNTL
110 120 130 140 150
KDCRSALDPL CGWCVNTQRC VQCISSGCHW SSSSKRCGWT QGREPQLNIQ
160 170 180 190 200
DACKDLLSEY KEPEILSLEP HKVSFNGRNN VLLRGRNLDS VTKIRIQGDL
210 220 230 240 250
GCIAKESPVF DPSSDTLVFN IPPSESKGTV KMCVVTPDNR CHGNSIITYS
260 270 280 290 300
SQPRCTGVQP RNSWRSGGRK IHVQGTNMEY VESVIVQPSN IFLKSQYDAS
310 320 330 340 350
SRDMWFYSHR IEGSDHFTLS LMVGNSTEAC DHDFSYEPDP VFTGFTTLQV
360 370 380 390 400
ANDLQVNIQK KADKLNLNIS EVKVAGLHGD KGYQCVVERI ESNAVICKIK
410 420 430 440 450
AGPGALDSLN ISIGHFYVKQ TFESPSGMKY FSILVVLIVI IILGAVVGVI
460 470 480 490 500
VHRKSQKQMS KKMNDQLELM ESNIRRDIRQ GFVDLQTEKS DLIDNVGAIP
510 520 530 540 550
FLDYKHFASR IFFPEAGTLT AVMIRDIGED SEQTTVDEKC LAFAELIRDK
560 570 580 590 600
QFLSCFVHAL EEQKNFSIKD KCTVASLLTL ALHGDLLYLT EIMEDLLQSL
610 620 630 640 650
MDQSSNANPK LLLRRTESIV EKLLTNWMSI CLYGFLRESV GQPLFLLVSA
660 670 680 690 700
LTQQISKGPV DSVTEKALYT LSEDWLLCQA QDFEPLKLKV VFAVGTGEEI
710 720 730 740 750
SESLEVIALT CDTIQQVKEK ILQTFQRKFG FRYTQQIRDI EIEYEKEGKF
760 770 780 790 800
VMLQEVDDTS EIRGHVTMLN TLKHYQVGDG ACIKVITPKI HAPLKTQNSV
810 820 830 840 850
KDDKNFSIKY FHLVDPDIDT DLSNHPEKKA LKIKEMYLIK LLSTKVAVHS
860 870 880 890 900
FVENLFKSIW GLPNNKAPLA VKYFFDFLDE QAERKKITDP DVLHIWKTNS
910 920 930 940 950
LPLRFWVNIL KNPDFVFSDM EKSPHLDGCL SVIAQAFMDS FSLTDTHLDK
960 970 980 990 1000
HSPTNKLLYG KDIPQYKQEV KSYYKLVKDQ TSISSQELKT FLQEESKKHQ
1010 1020 1030 1040 1050
NEFNESAALR ELYKYMQRYF TEIFQKLEQT DAPSNLKENM HRVKELFDNM
KRSGWN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1QS13 | F1QS13_DANRE | Plexin C1 | plxnc1 | 464 | Annotation score: | ||
A0A2R8QT09 | A0A2R8QT09_DANRE | Plexin C1 | plxnc1 | 387 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX649503 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000135735; ENSDARP00000115802; ENSDARG00000015278 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX649503 Genomic DNA No translation available. |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4M8M | X-ray | 3.31 | A/B | 456-1056 | [»] | |
4M8N | X-ray | 3.29 | A/B/C/D | 455-1050 | [»] | |
SMRi | Q5RGW1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PaxDbi | Q5RGW1 |
Genome annotation databases
Ensembli | ENSDART00000135735; ENSDARP00000115802; ENSDARG00000015278 |
Organism-specific databases
ZFINi | ZDB-GENE-030131-1620, plxnc1 |
Phylogenomic databases
GeneTreei | ENSGT01020000230384 |
HOGENOMi | CLU_004205_0_0_1 |
OMAi | LFHGENK |
PhylomeDBi | Q5RGW1 |
Gene expression databases
Bgeei | ENSDARG00000015278, Expressed in granulocyte and 21 other tissues |
ExpressionAtlasi | Q5RGW1, baseline and differential |
Family and domain databases
Gene3Di | 1.10.506.10, 1 hit 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR002909, IPT_dom IPR031148, Plexin IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 2 hits |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01833, TIG, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5RGW1_DANRE | |
Accessioni | Q5RGW1Primary (citable) accession number: Q5RGW1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 123 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |