UniProtKB - Q5RGG3 (Q5RGG3_DANRE)
Protein
Hepatocyte growth factor
Gene
hgfa
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- central nervous system neuron differentiation Source: ZFIN
- cerebellar granule cell differentiation Source: ZFIN
- cerebellum development Source: ZFIN
- cerebellum morphogenesis Source: ZFIN
- neuron migration Source: ZFIN
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation, Serine protease homologUniRule annotation |
Protein family/group databases
MEROPSi | S01.976 |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatocyte growth factorUniRule annotationARBA annotationAlternative name(s): Hepatopoietin-AUniRule annotation Scatter factorUniRule annotation |
Gene namesi | Name:hgfaImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-041014-2, hgfa |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5004262519 | 24 – 699 | Hepatocyte growth factorSequence analysisAdd BLAST | 676 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 196 ↔ 273 | PROSITE-ProRule annotation | ||
Disulfide bondi | 217 ↔ 256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 245 ↔ 268 | PROSITE-ProRule annotation | ||
Disulfide bondi | 308 ↔ 347 | PROSITE-ProRule annotation | ||
Disulfide bondi | 336 ↔ 359 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, Pyrrolidone carboxylic acidARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000045544, Expressed in multi-cellular organism and 32 other tissues |
ExpressionAtlasi | Q5RGG3, baseline |
Interactioni
Subunit structurei
Dimer of an alpha chain and a beta chain linked by a disulfide bond.
UniRule annotationGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 108 | AppleInterPro annotationAdd BLAST | 86 | |
Domaini | 112 – 191 | KringleInterPro annotationAdd BLAST | 80 | |
Domaini | 195 – 273 | KringleInterPro annotationAdd BLAST | 79 | |
Domaini | 286 – 365 | KringleInterPro annotationAdd BLAST | 80 | |
Domaini | 374 – 451 | KringleInterPro annotationAdd BLAST | 78 | |
Domaini | 466 – 690 | Peptidase S1InterPro annotationAdd BLAST | 225 |
Sequence similaritiesi
Keywords - Domaini
KringlePROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156019 |
HOGENOMi | CLU_017565_0_0_1 |
TreeFami | TF329901 |
Family and domain databases
CDDi | cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom |
Pfami | View protein in Pfam PF00051, Kringle, 4 hits PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 3 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5RGG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSDIMWMYQ ALLFVVLTVN VDCRKQTLQR YQKSENSRLL CTDCPESPRI
60 70 80 90 100
RNLSLEECAR KCSKSKKSCR AFYFDHINRK CHFLPFDRFS EGAKRERKPS
110 120 130 140 150
CDLYEKKDYV RECIIGSGVN YKGRRSFTKT GITCQSWNMS VPHEHNFKPT
160 170 180 190 200
RHKKSDLRQN FCRNPDNDPN GPWCFTELTE TRHQDCGLPQ CSDVECMKCN
210 220 230 240 250
GETYRGPMDH TESGKECQRW DSQKPHKHTY QPHRHVGKGL DDNFCRNPNN
260 270 280 290 300
DVRPWCYTMD KNTPWEYCNI SVCDSDSDVE VEVTSSCFRG QGEGYRGTVN
310 320 330 340 350
VTPAGVTCQR WDALSPHIHS YTPHNYKCKD LRENYCRNPD GSEIPWCFTT
360 370 380 390 400
DAKVRKAFCT NIPRCESESS DSTECYEDNG ESYRGNLSKT RSGIPCGLWS
410 420 430 440 450
DHTFRRDTRS AKASAGLELN LCRNPDRDKH GPWCYTSNSS IPWDYCGLER
460 470 480 490 500
CGGPKPSCFI HKTTRIVGGM RVQRAEDGSW VVSIQKGNRH WCGGSLIREE
510 520 530 540 550
WVLTDQQCFS TCVPDLSEYT VQVGLLHLNA SAGTQALRIA HVVCGPEGSN
560 570 580 590 600
LALLKLTTPA PLSEHVRTVQ LPVAGCAVAE GTLCLMYGWG DTKGHEGSLK
610 620 630 640 650
MVGLPIVSNK RCSQSHNGIL PITETKICAG GKRDQGVCEK DYGGPLVCQE
660 670 680 690
GESKVIVGVS INGRGCAVAR RPAVFVNVAF YSEWIRKVFK YYSDMEISY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1REK1 | F1REK1_DANRE | Hepatocyte growth factor | hgfa | 712 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX897731 Genomic DNA No translation available. |
RefSeqi | NP_001013292.1, NM_001013274.1 |
Genome annotation databases
Ensembli | ENSDART00000100952; ENSDARP00000091725; ENSDARG00000045544 |
GeneIDi | 493781 |
KEGGi | dre:493781 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX897731 Genomic DNA No translation available. |
RefSeqi | NP_001013292.1, NM_001013274.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | S01.976 |
Genome annotation databases
Ensembli | ENSDART00000100952; ENSDARP00000091725; ENSDARG00000045544 |
GeneIDi | 493781 |
KEGGi | dre:493781 |
Organism-specific databases
CTDi | 493781 |
ZFINi | ZDB-GENE-041014-2, hgfa |
Phylogenomic databases
GeneTreei | ENSGT00940000156019 |
HOGENOMi | CLU_017565_0_0_1 |
TreeFami | TF329901 |
Gene expression databases
Bgeei | ENSDARG00000045544, Expressed in multi-cellular organism and 32 other tissues |
ExpressionAtlasi | Q5RGG3, baseline |
Family and domain databases
CDDi | cd00108, KR, 4 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR027284, Hepatocyte_GF IPR024174, HGF/MST1 IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom |
Pfami | View protein in Pfam PF00051, Kringle, 4 hits PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF500183, Hepatocyte_GF, 1 hit PIRSF001152, HGF_MST1, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 4 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 4 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 3 hits PS50070, KRINGLE_2, 4 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5RGG3_DANRE | |
Accessioni | Q5RGG3Primary (citable) accession number: Q5RGG3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |