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Protein

YTH domain-containing family protein 3

Gene

YTHDF3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Shares m6A-containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context. Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits. Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs) and promotes their translation. circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei428N6-methyladenosineBy similarity1
Binding sitei468N6-methyladenosineBy similarity1
Binding sitei492N6-methyladenosineBy similarity1
Binding sitei497N6-methyladenosineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
YTH domain-containing family protein 3
Gene namesi
Name:YTHDF3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002309932 – 585YTH domain-containing family protein 3Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Interacts with YTHDF1. Interacts with YTHDF2.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020890

Structurei

3D structure databases

ProteinModelPortaliQ5RFL8
SMRiQ5RFL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini416 – 550YTHPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni422 – 424N6-methyladenosine bindingBy similarity3
Regioni438 – 439N6-methyladenosine bindingBy similarity2

Phylogenomic databases

eggNOGiKOG1901 Eukaryota
ENOG410YABQ LUCA
HOVERGENiHBG060315
InParanoidiQ5RFL8
KOiK20102

Family and domain databases

InterProiView protein in InterPro
IPR007275 YTH_domain
PfamiView protein in Pfam
PF04146 YTH, 1 hit
PROSITEiView protein in PROSITE
PS50882 YTH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATSVDQRP KGQGNKVSVQ NGSIHQKDAV NDDDFEPYLS SQTNQSNSYP
60 70 80 90 100
PMSDPYMPSY YAPSIGFPYS LGEAAWSTAG DQPMPYLTTY GQMSNGEHHY
110 120 130 140 150
IPDGVFSQPG ALGNTPPFLG QHGFNFFPGN ADFSTWGTSG SQGQSTQSSA
160 170 180 190 200
YSSSYGYPPS SLGRAITDGQ AGFGNDTLSK VPGISSIEQG MTGLKIGGDL
210 220 230 240 250
TAAVTKTVGT ALSSSGMTSI ATNSVPPVSS AAPKPTSWAA IARKPAKPQP
260 270 280 290 300
KLKPKGNVGI GGSAVPPPPI KHNMNIGTWD EKGSVVKAPP TQPVLPPQTI
310 320 330 340 350
IQQPQPLIQP PPLVQSQLPQ QQPQPPQPQQ QQGPQPQAQP HQVQPQQQQL
360 370 380 390 400
QNRWVAPRNR GAGFNQNNGA GSENFGLGVV PVSASPSSVE VHPVLEKLKA
410 420 430 440 450
INNYNPKDFD WNLKNGRVFI IKSYSEDDIH RSIKYSIWCS TEHGNKRLDA
460 470 480 490 500
AYRSLNGKGP LYLLFSVNGS GHFCGVAEMK SVVDYNAYAG VWSQDKWKGK
510 520 530 540 550
FEVKWIFVKD VPNNQLRHIR LENNDNKPVT NSRDTQEVPL EKAKQVLKII
560 570 580
ATFKHTTSIF DDFAHYEKRQ EEEEAMRRER NRNKQ
Length:585
Mass (Da):63,861
Last modified:December 21, 2004 - v1
Checksum:iC7021FE48DEA441E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857137 mRNA Translation: CAH89439.1
RefSeqiNP_001124613.1, NM_001131141.1
UniGeneiPab.940

Genome annotation databases

GeneIDi100171450
KEGGipon:100171450

Similar proteinsi

Entry informationi

Entry nameiYTHD3_PONAB
AccessioniPrimary (citable) accession number: Q5RFL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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