UniProtKB - Q5RFA2 (SYFA_PONAB)
Protein
Phenylalanine--tRNA ligase alpha subunit
Gene
FARSA
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Catalytic activityi
- EC:6.1.1.20By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 329 | L-phenylalanineBy similarity | 1 | |
Binding sitei | 435 | L-phenylalanineBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- phenylalanine-tRNA ligase activity Source: UniProtKB
- tRNA binding Source: InterPro
GO - Biological processi
- phenylalanyl-tRNA aminoacylation Source: UniProtKB
- protein heterotetramerization Source: UniProtKB
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20By similarity)Alternative name(s): Phenylalanyl-tRNA synthetase alpha subunit Short name: PheRS |
Gene namesi | Name:FARSA Synonyms:FARSLA |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Other locations
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB
- phenylalanine-tRNA ligase complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000280448 | 2 – 508 | Phenylalanine--tRNA ligase alpha subunitAdd BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 190 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineBy similarity | 1 | |
Modified residuei | 301 | PhosphoserineBy similarity | 1 | |
Modified residuei | 311 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PRIDEi | Q5RFA2 |
Interactioni
Subunit structurei
Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000010779 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 372 – 374 | L-phenylalanine bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG2784, Eukaryota |
GeneTreei | ENSGT00390000006387 |
HOGENOMi | CLU_025086_2_2_1 |
InParanoidi | Q5RFA2 |
OMAi | QIEGWVM |
OrthoDBi | 733355at2759 |
TreeFami | TF300647 |
Family and domain databases
InterProi | View protein in InterPro IPR006195, aa-tRNA-synth_II IPR004529, Phe-tRNA-synth_IIc_asu IPR002319, Phenylalanyl-tRNA_Synthase IPR040724, PheRS_DBD1 IPR040586, PheRS_DBD2 IPR040725, PheRS_DBD3 IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF18552, PheRS_DBD1, 1 hit PF18554, PheRS_DBD2, 1 hit PF18553, PheRS_DBD3, 1 hit PF01409, tRNA-synt_2d, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR00468, pheS, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5RFA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADGPVAELL LRRLEASDGG LDSAELAAEL GMEHQAVVGA VKSLQALGEV
60 70 80 90 100
IEAELRSTKR WELTAEGEEI AREGSHEARV FRSIPPEGLA QSELMRLPSG
110 120 130 140 150
KVGFSKAMSN KWIRVDKSAA DGPRVFRVVD SMEDEVQRRL QLVRGGQAEK
160 170 180 190 200
LGEKERSELR KRKLLAEVIL KTYWVSKGSA FSTSISKQET ELSPEMISSG
210 220 230 240 250
SWRDRPFKPY NFLAHGVLPD SGHLHPLLKV RSQFRQIFLE MGFTEMPTDN
260 270 280 290 300
FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM DYVQRVKRTH
310 320 330 340 350
SQGGYGSQGY KYNWKLDEAR KNLLRTHTTS ASARALYRLA QKKPFTPVKY
360 370 380 390 400
FSIDRVFRNE TLDATHLAEF HQIEGVVADH GLTLGHLMGV LREFFTKLGI
410 420 430 440 450
TQLRFKPAYN PYTEPSMEVF SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE
460 470 480 490 500
NVSVIAWGLS LERPTMIKYG INNIRELVGH KVNLQMVYDS PLCRLDAEPR
PPPTQEAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR857259 mRNA Translation: CAH89555.1 |
RefSeqi | NP_001127167.1, NM_001133695.2 |
Genome annotation databases
Ensembli | ENSPPYT00000011201; ENSPPYP00000010779; ENSPPYG00000009615 |
GeneIDi | 100174218 |
KEGGi | pon:100174218 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR857259 mRNA Translation: CAH89555.1 |
RefSeqi | NP_001127167.1, NM_001133695.2 |
3D structure databases
SMRi | Q5RFA2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000010779 |
Proteomic databases
PRIDEi | Q5RFA2 |
Genome annotation databases
Ensembli | ENSPPYT00000011201; ENSPPYP00000010779; ENSPPYG00000009615 |
GeneIDi | 100174218 |
KEGGi | pon:100174218 |
Organism-specific databases
CTDi | 2193 |
Phylogenomic databases
eggNOGi | KOG2784, Eukaryota |
GeneTreei | ENSGT00390000006387 |
HOGENOMi | CLU_025086_2_2_1 |
InParanoidi | Q5RFA2 |
OMAi | QIEGWVM |
OrthoDBi | 733355at2759 |
TreeFami | TF300647 |
Family and domain databases
InterProi | View protein in InterPro IPR006195, aa-tRNA-synth_II IPR004529, Phe-tRNA-synth_IIc_asu IPR002319, Phenylalanyl-tRNA_Synthase IPR040724, PheRS_DBD1 IPR040586, PheRS_DBD2 IPR040725, PheRS_DBD3 IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF18552, PheRS_DBD1, 1 hit PF18554, PheRS_DBD2, 1 hit PF18553, PheRS_DBD3, 1 hit PF01409, tRNA-synt_2d, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR00468, pheS, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYFA_PONAB | |
Accessioni | Q5RFA2Primary (citable) accession number: Q5RFA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries