UniProtKB - Q5REX5 (ABHDA_PONAB)
Protein
Palmitoyl-protein thioesterase ABHD10, mitochondrial
Gene
ABHD10
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.By similarity
Catalytic activityi
- H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]By similarityEC:3.1.2.22By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:3.1.1.93By similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Inhibited by palmostatin-B.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 152 | Charge relay systemBy similarity | 1 | |
Active sitei | 249 | Charge relay systemBy similarity | 1 | |
Active sitei | 279 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- mycophenolic acid acyl-glucuronide esterase activity Source: UniProtKB-EC
- palmitoyl-(protein) hydrolase activity Source: UniProtKB
GO - Biological processi
- protein depalmitoylation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Protein family/group databases
ESTHERi | ponab-abhda, ABHD10 |
MEROPSi | S09.023 |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoyl-protein thioesterase ABHD10, mitochondrialBy similarity (EC:3.1.2.22By similarity)Alternative name(s): Acyl-protein thioesterase ABHD10By similarity Alpha/beta hydrolase domain-containing protein 10By similarity Short name: Abhydrolase domain-containing protein 10By similarity Mycophenolic acid acyl-glucuronide esterase, mitochondrialBy similarity (EC:3.1.1.93By similarity) |
Gene namesi | Name:ABHD10 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 52 | MitochondrionSequence analysisAdd BLAST | 52 | |
ChainiPRO_0000280735 | 53 – 306 | Palmitoyl-protein thioesterase ABHD10, mitochondrialAdd BLAST | 254 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 177 | AB hydrolase-1Sequence analysisAdd BLAST | 100 |
Sequence similaritiesi
Belongs to the AB hydrolase superfamily.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502QT21, Eukaryota |
InParanoidi | Q5REX5 |
OrthoDBi | 1106156at2759 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5REX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVARLAAVA AWVPCRSWGC AAVPFGPHRG LSALLARIPQ RAPRWLPACR
60 70 80 90 100
QKTSLSFLNR PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC
110 120 130 140 150
KSLGHACIRF DYSGVGSSDG NSEESTLGKW RKDVLSIIDD LADGPQILVG
160 170 180 190 200
SSLGGWLMLH AAIARPEKVV ALLGVATAAD TLVTKFNQLP VELKKEVEMK
210 220 230 240 250
GVWSMPSKYS EEGVYNIQYS FIKEAEHHCL LHSPIPVNCP IRLLHGMKDD
260 270 280 290 300
IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MKEKADIQLL VYTIDDLIDK
LSTIVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR857388 mRNA Translation: CAH89682.1 |
RefSeqi | NP_001124761.1, NM_001131289.1 |
Genome annotation databases
GeneIDi | 100171612 |
KEGGi | pon:100171612 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR857388 mRNA Translation: CAH89682.1 |
RefSeqi | NP_001124761.1, NM_001131289.1 |
3D structure databases
SMRi | Q5REX5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000015158 |
Protein family/group databases
ESTHERi | ponab-abhda, ABHD10 |
MEROPSi | S09.023 |
Genome annotation databases
GeneIDi | 100171612 |
KEGGi | pon:100171612 |
Organism-specific databases
CTDi | 55347 |
Phylogenomic databases
eggNOGi | ENOG502QT21, Eukaryota |
InParanoidi | Q5REX5 |
OrthoDBi | 1106156at2759 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABHDA_PONAB | |
Accessioni | Q5REX5Primary (citable) accession number: Q5REX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families