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Entry version 64 (02 Dec 2020)
Sequence version 2 (20 Mar 2007)
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Protein

Protein ITPRID2

Gene

ITPRID2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ITPRID2Curated
Alternative name(s):
ITPR-interacting domain-containing protein 2Curated
Sperm-specific antigen 2 homologBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITPRID2By similarity
Synonyms:SSFA2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807071 – 768Protein ITPRID2Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153PhosphoserineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei246PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei378PhosphoserineBy similarity1
Modified residuei411PhosphoserineBy similarity1
Modified residuei549PhosphoserineBy similarity1
Modified residuei564PhosphoserineBy similarity1
Modified residuei569PhosphoserineBy similarity1
Modified residuei572PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1
Modified residuei643PhosphoserineBy similarity1
Modified residuei665PhosphothreonineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei677PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000014512

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5REU9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili468 – 546Sequence analysisAdd BLAST79

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSG8, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5REU9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026648, ITPRID2
IPR029326, SSFA2_C
IPR043444, TESPA1-like

The PANTHER Classification System

More...
PANTHERi
PTHR17469, PTHR17469, 1 hit
PTHR17469:SF11, PTHR17469:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14723, SSFA2_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5REU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTEDHLLRT ASQHSDSSGF AEDSTDCLSL NHLQVQESLQ AMGSSADSCD
60 70 80 90 100
SETTVTSLGE DLATPTAQDQ PYFNESEEES LVPLQKGLEK AAAIADRRKS
110 120 130 140 150
GSQDFPQCNT IENPGTKQST CSPGDRVTEI TEVEEDLFPA ETVELLREAS
160 170 180 190 200
AESDVDKSSE CEFTQYTTHH ILKSLASIEA KCSDMSSENT TGPPSSVDRV
210 220 230 240 250
NTALQRAQMK VCTLSNQRMG RSLLKSKDLL KQRYLFAKVG YPLRRSQSLP
260 270 280 290 300
TTLLSPVRVV SSVNVRLSPG KETRCSPPSF TYKYTPEEEQ ELEKRAMEHD
310 320 330 340 350
GQSLVKSTIF ISPSSVKKEE APQSEAPRVE ECHHGRTPTC SRLAPPPMSQ
360 370 380 390 400
STCSLHSIHS EWQERPLCEH TRTLSTHSVP NISGATCSAF ASPFGCPYSH
410 420 430 440 450
RHATYPYRVC SVNPPSAIEM QLRRVLHDIR NSLQNLSQYP MMRGPDPAAA
460 470 480 490 500
PYSTQKSSVL PLYENTFQEL QVMRRSLNLF RTQMMDLELA MLRQQTMVYH
510 520 530 540 550
HMTEEERFEV DQLQGLRNSV RMELQDLELQ LEERLLGLEE QLRAVRMPSP
560 570 580 590 600
FRSSALMGMC GSRSADNLSC PSPLNVMEPV TELMQEQSYL KSELGLGLGE
610 620 630 640 650
MGFEIPPGES SESVFSQATS ESSSVCSGPS HANRRTGVPS TASVGKPKTP
660 670 680 690 700
LVARKKVFRA SVALTPTAPS RTGSVQTPPD LESSEEVDAA EEAPEVVGPK
710 720 730 740 750
SEVEEGHGKL PSMPAAEEMH KNVEQDELQQ VIREIKESIV GEIRREIVSG
760
LLAAVSSSKA SNSKQDNH
Length:768
Mass (Da):84,713
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D86D17B411D8A62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25T → I in CAH89707 (Ref. 1) Curated1
Sequence conflicti97R → G in CAH89707 (Ref. 1) Curated1
Sequence conflicti201N → S in CAH89707 (Ref. 1) Curated1
Sequence conflicti298E → G in CAH89707 (Ref. 1) Curated1
Sequence conflicti429I → V in CAH89707 (Ref. 1) Curated1
Sequence conflicti531L → Q in CAH89708 (Ref. 1) Curated1
Sequence conflicti595G → R in CAH89708 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR857416 mRNA Translation: CAH89707.1
CR857417 mRNA Translation: CAH89708.1

NCBI Reference Sequences

More...
RefSeqi
NP_001124775.1, NM_001131303.1
NP_001128928.1, NM_001135456.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100189884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pon:100189884

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857416 mRNA Translation: CAH89707.1
CR857417 mRNA Translation: CAH89708.1
RefSeqiNP_001124775.1, NM_001131303.1
NP_001128928.1, NM_001135456.1

3D structure databases

SMRiQ5REU9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000014512

Genome annotation databases

GeneIDi100189884
KEGGipon:100189884

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6744

Phylogenomic databases

eggNOGiENOG502QSG8, Eukaryota
InParanoidiQ5REU9

Family and domain databases

InterProiView protein in InterPro
IPR026648, ITPRID2
IPR029326, SSFA2_C
IPR043444, TESPA1-like
PANTHERiPTHR17469, PTHR17469, 1 hit
PTHR17469:SF11, PTHR17469:SF11, 1 hit
PfamiView protein in Pfam
PF14723, SSFA2_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPI2_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5REU9
Secondary accession number(s): Q5REV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: December 2, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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