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Protein

Transmembrane 4 L6 family member 1

Gene

TM4SF1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Gene namesi
Name:TM4SF1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicCurated9
Transmembranei10 – 30HelicalCuratedAdd BLAST21
Topological domaini31 – 49ExtracellularCuratedAdd BLAST19
Transmembranei50 – 70HelicalCuratedAdd BLAST21
Topological domaini71 – 93CytoplasmicCuratedAdd BLAST23
Transmembranei94 – 114HelicalCuratedAdd BLAST21
Topological domaini115 – 161ExtracellularCuratedAdd BLAST47
Transmembranei162 – 182HelicalCuratedAdd BLAST21
Topological domaini183 – 202CytoplasmicCuratedAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192981 – 202Transmembrane 4 L6 family member 1Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Present in high molecular weight complexes in tumor cells. Interacts with SDCBP2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015877

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1N Eukaryota
ENOG410YCUU LUCA
HOVERGENiHBG000076
InParanoidiQ5RE43

Family and domain databases

InterProiView protein in InterPro
IPR008661 L6_membrane
PANTHERiPTHR14198 PTHR14198, 1 hit
PfamiView protein in Pfam
PF05805 L6_membrane, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RE43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETRYASE NHLSRFVWFF
60 70 80 90 100
SGIVGGGLLM LLPAFVLIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG
110 120 130 140 150
IAGSGYCVIV AALGLAEGPL CLDSLGQWNY TFASTEGQYL LDTSTWSQCT
160 170 180 190 200
EPKHIVEWNV SLFSILLALG GIEFILCLIQ VINGVLGGIC GFCCSRQQQY

DC
Length:202
Mass (Da):21,644
Last modified:December 21, 2004 - v1
Checksum:i2B4E56AA8EEC1424
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857695 mRNA Translation: CAH89964.1
RefSeqiNP_001124924.1, NM_001131452.1

Genome annotation databases

GeneIDi100171795
KEGGipon:100171795

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857695 mRNA Translation: CAH89964.1
RefSeqiNP_001124924.1, NM_001131452.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015877

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100171795
KEGGipon:100171795

Organism-specific databases

CTDi4071

Phylogenomic databases

eggNOGiENOG410IE1N Eukaryota
ENOG410YCUU LUCA
HOVERGENiHBG000076
InParanoidiQ5RE43

Family and domain databases

InterProiView protein in InterPro
IPR008661 L6_membrane
PANTHERiPTHR14198 PTHR14198, 1 hit
PfamiView protein in Pfam
PF05805 L6_membrane, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT4S1_PONAB
AccessioniPrimary (citable) accession number: Q5RE43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: November 22, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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