Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acylpyruvase FAHD1, mitochondrial

Gene

FAHD1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity.By similarity

Catalytic activityi

A 3-acylpyruvate + H2O = a carboxylate + pyruvate.By similarity
Oxaloacetate = pyruvate + CO2.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Divalent metal cationBy similarity1
Metal bindingi73Divalent metal cationBy similarity1
Metal bindingi102Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase
LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acylpyruvase FAHD1, mitochondrial (EC:3.7.1.5By similarity)
Alternative name(s):
Fumarylacetoacetate hydrolase domain-containing protein 1
Oxaloacetate decarboxylaseBy similarity (EC:4.1.1.3By similarity)
Short name:
OAA decarboxylaseBy similarity
Gene namesi
Name:FAHD1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000015683128 – 224Acylpyruvase FAHD1, mitochondrialAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineBy similarity1
Modified residuei113N6-acetyllysineBy similarity1
Modified residuei115N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5RDW0

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000007888

Structurei

3D structure databases

ProteinModelPortaliQ5RDW0
SMRiQ5RDW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1535 Eukaryota
COG0179 LUCA
GeneTreeiENSGT00530000063832
HOVERGENiHBG057495
InParanoidiQ5RDW0
KOiK01557
OMAiSRFWEWG
OrthoDBiEOG091G0I6G
TreeFamiTF300911

Family and domain databases

Gene3Di3.90.850.10, 1 hit
InterProiView protein in InterPro
IPR011234 Fumarylacetoacetase-like_C
IPR036663 Fumarylacetoacetase_C_sf
PfamiView protein in Pfam
PF01557 FAA_hydrolase, 1 hit
SUPFAMiSSF56529 SSF56529, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RDW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIMAASRPL SRFWEWGKNI VCVGRNYADH VREMRSAVLS EPVLFLKPST
60 70 80 90 100
AYAPEGSPIL MPAYTRNLHH ELELGVVMGR RCRAVPEAAA MDYVGGYALC
110 120 130 140 150
LDMTARDVQD ECKKKGLPWT LAKSFTASCP VSAFVPKEKI PDPHKLKLWL
160 170 180 190 200
KVNGELRQEG ETSSMIFSIP YIISYVSKII TLEEGDIILT GTPKGVGPVK
210 220
ENDEIEAGIH GLVSMRFKVE KPEY
Length:224
Mass (Da):24,926
Last modified:December 21, 2004 - v1
Checksum:i34BD8F5B2613D599
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857783 mRNA Translation: CAH90047.1
RefSeqiNP_001124978.1, NM_001131506.1
UniGeneiPab.14388

Genome annotation databases

EnsembliENSPPYT00000008215; ENSPPYP00000007888; ENSPPYG00000006967
GeneIDi100171851
KEGGipon:100171851

Similar proteinsi

Entry informationi

Entry nameiFAHD1_PONAB
AccessioniPrimary (citable) accession number: Q5RDW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health