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Protein

Allograft inflammatory factor 1-like

Gene

AIF1L

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1-like
Alternative name(s):
Ionized calcium-binding adapter molecule 2
Gene namesi
Name:AIF1L
Synonyms:IBA2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000738722 – 150Allograft inflammatory factor 1-likeAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer (Potential). Monomer (By similarity).By similarityCurated

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5RDI4
SMRiQ5RDI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 82EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini83 – 117EF-hand 2; degeneratePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG004002
InParanoidiQ5RDI4
KOiK18617

Family and domain databases

InterProiView protein in InterPro
IPR028453 Aif1-like
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PANTHERiPTHR10356:SF5 PTHR10356:SF5, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RDI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGELSNRFQ GGKAFGLLKA RQERRLAEID REFLCDQKYS DEENLPEKLT
60 70 80 90 100
AFKEKYMEFD LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS
110 120 130 140 150
DTISYRDFVN MMLGKRSAVL KLVMMFEGKA NESSPKPVGP PPERDIASLP
Length:150
Mass (Da):17,069
Last modified:December 21, 2004 - v1
Checksum:i70814E36B9DEBFF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857925 mRNA Translation: CAH90173.1
RefSeqiNP_001125057.1, NM_001131585.1
UniGeneiPab.14046

Genome annotation databases

GeneIDi100171938
KEGGipon:100171938

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857925 mRNA Translation: CAH90173.1
RefSeqiNP_001125057.1, NM_001131585.1
UniGeneiPab.14046

3D structure databases

ProteinModelPortaliQ5RDI4
SMRiQ5RDI4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100171938
KEGGipon:100171938

Organism-specific databases

CTDi83543

Phylogenomic databases

HOVERGENiHBG004002
InParanoidiQ5RDI4
KOiK18617

Family and domain databases

InterProiView protein in InterPro
IPR028453 Aif1-like
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PANTHERiPTHR10356:SF5 PTHR10356:SF5, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIF1L_PONAB
AccessioniPrimary (citable) accession number: Q5RDI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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