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Entry version 82 (02 Dec 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasma membrane anion exchange protein of wide distribution.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Antiport, Ion transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Solute carrier family 4 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A2
Synonyms:AE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 706CytoplasmicSequence analysisAdd BLAST706
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei707 – 727HelicalSequence analysisAdd BLAST21
Transmembranei752 – 772HelicalSequence analysisAdd BLAST21
Transmembranei794 – 814HelicalSequence analysisAdd BLAST21
Transmembranei824 – 844HelicalSequence analysisAdd BLAST21
Topological domaini845 – 895ExtracellularSequence analysisAdd BLAST51
Transmembranei896 – 916HelicalSequence analysisAdd BLAST21
Topological domaini917 – 931CytoplasmicSequence analysisAdd BLAST15
Transmembranei932 – 952HelicalSequence analysisAdd BLAST21
Transmembranei987 – 1007HelicalSequence analysisAdd BLAST21
Transmembranei1034 – 1054HelicalSequence analysisAdd BLAST21
Transmembranei1088 – 1108HelicalSequence analysisAdd BLAST21
Transmembranei1111 – 1131HelicalSequence analysisAdd BLAST21
Transmembranei1172 – 1192HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003540921 – 1239Anion exchange protein 2Add BLAST1239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei241PhosphoserineBy similarity1
Modified residuei255PhosphothreonineBy similarity1
Modified residuei272N6-methyllysineBy similarity1
Modified residuei441PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi880N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1171S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000020391

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5RD44

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni706 – 1239Membrane (anion exchange)Add BLAST534
Regioni708 – 1239Membrane (anion exchange)Add BLAST532

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 119Pro-richAdd BLAST115
Compositional biasi74 – 88His-richAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5RD44

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001717, Anion_exchange
IPR002978, Anion_exchange_2
IPR018241, Anion_exchange_CS
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453, PTHR11453, 1 hit
PTHR11453:SF14, PTHR11453:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00165, ANIONEXCHNGR
PR01188, ANIONEXHNGR2
PR01231, HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834, ae, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00219, ANION_EXCHANGER_1, 1 hit
PS00220, ANION_EXCHANGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5RD44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGETPT IEEGEEDEDE ASEAEGARAL TQPSPVSTPS
160 170 180 190 200
SVQFFLQEDD SADRKAERTS PSSPAPLPHQ EATPRASKGA QAGTQVEEAE
210 220 230 240 250
AVAVASGTAG GDDGGASGRP LPKAQPGHRS YNLQERRRIG SMTGAEQALL
260 270 280 290 300
PRVPTDEIEA QTLATADLDL MKSHRFEDVP GVRRHLVRKN AKGSTQSGRE
310 320 330 340 350
GREPGPTPRA RPRAPHKPHE VFVELNELLL DKNQEPQWRE TARWIKFEED
360 370 380 390 400
VEEETERWGK PHVASLSFRS LLELRRTLAH GAVLLDLDQQ TLPGVAHQVV
410 420 430 440 450
EQMVISDQIK AEDRANVLRA LLLKHSHPSD EKDFSFPRNI SAGSLGSLLG
460 470 480 490 500
HHHGQGAESD PHVTEPLIGG VPETRLEVER ERELPPPAPP AGITRSKSKH
510 520 530 540 550
ELKLLEKIPE NAEATVVLVG CVEFLSRPTM AFVRLREAVE LDAVLEVPVP
560 570 580 590 600
VRFLFLLLGP SSANMDYHEI GRSISTLMSD KQFHEAAYLA DEREDLLTAI
610 620 630 640 650
NAFLDCSVVL PPSEVQGEEL LRSVAHFQRQ MLKKREEQGR LLPTGAGLEP
660 670 680 690 700
KSAQDKALLQ MVEAAGAAED DPLRRTGRPF GGLIRDVRRR YPHYLSDFRD
710 720 730 740 750
ALDPQCLAAV IFIYFAALSP AITFGGLLGE KTQDLIGVSE LIMSTALQGV
760 770 780 790 800
VFCLLGAQPL LVIGFSGPLL VFEEAFFSFC SSNHLEYLVG RVWIGFWLVL
810 820 830 840 850
LALLMVALEG SFLVRFVSRF TQEIFAFLIS LIFIYETFYK LVKIFQEHPL
860 870 880 890 900
HGCSASNSSE VDGGENMTWA VARPTLGPGN RSLAGQSGQG KPRGQPNTAL
910 920 930 940 950
LSLVLMAGTF FIAFFLRKFK NSRFFPGRIR RVIGDFGVPI AILIMVLVDY
960 970 980 990 1000
SIEDTYTQKL SVPSGFSVTA PEKRGWVINP LGEKSPFPVW MMVASLLPAI
1010 1020 1030 1040 1050
LVFILIFMET QITTLIISKK ERMLQKGSGF HLDLLLIVAM GGICALFGLP
1060 1070 1080 1090 1100
WLAAATVRSV THANALTVMS KAVAPGDKPK IQEVKEQRVT GLLVALLVGL
1110 1120 1130 1140 1150
SIVIGDLLRQ IPLAVLFGIF LYMGVTSLNG IQFYERLHLL LMPPKHHPDV
1160 1170 1180 1190 1200
TYVKKVRTLR MHLFTALQLL CLALLWAVMS TAASLAFPFI LILTVPLRMV
1210 1220 1230
VLTRIFTDRE MKCLDANEAE PVFDEREGVD EYNEMPMPV
Length:1,239
Mass (Da):136,799
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1D8EC8179CE22F5
GO
Isoform 2 (identifier: Q5RD44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MDFLLRPQ

Show »
Length:1,230
Mass (Da):136,036
Checksum:iBA90E551B67D94D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti471V → A in CAH92278 (Ref. 1) Curated1
Sequence conflicti516V → A in CAH92278 (Ref. 1) Curated1
Sequence conflicti1066L → P in CAH90313 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357831 – 17MSSAP…DSFCT → MDFLLRPQ in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR858074 mRNA Translation: CAH90313.1
CR860134 mRNA Translation: CAH92278.1

NCBI Reference Sequences

More...
RefSeqi
NP_001125144.1, NM_001131672.1
NP_001128854.1, NM_001135382.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100172030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pon:100172030

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858074 mRNA Translation: CAH90313.1
CR860134 mRNA Translation: CAH92278.1
RefSeqiNP_001125144.1, NM_001131672.1
NP_001128854.1, NM_001135382.2

3D structure databases

SMRiQ5RD44
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020391

Genome annotation databases

GeneIDi100172030
KEGGipon:100172030

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6522

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
InParanoidiQ5RD44
OrthoDBi265068at2759

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717, Anion_exchange
IPR002978, Anion_exchange_2
IPR018241, Anion_exchange_CS
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PTHR11453:SF14, PTHR11453:SF14, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR00165, ANIONEXCHNGR
PR01188, ANIONEXHNGR2
PR01231, HCO3TRNSPORT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit
PROSITEiView protein in PROSITE
PS00219, ANION_EXCHANGER_1, 1 hit
PS00220, ANION_EXCHANGER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3A2_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5RD44
Secondary accession number(s): Q5R7I2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 2, 2020
This is version 82 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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