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Protein

Alpha-1-antitrypsin

Gene

SERPINA1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei382 – 383Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processAcute phase

Protein family/group databases

MEROPSiI04.001

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antitrypsin
Alternative name(s):
Alpha-1 protease inhibitor
Alpha-1-antiproteinase
Serpin A1
Gene namesi
Name:SERPINA1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003237925 – 418Alpha-1-antitrypsinAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineBy similarity1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei383PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ5RCW5

Expressioni

Tissue specificityi

Plasma.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006940

Structurei

3D structure databases

ProteinModelPortaliQ5RCW5
SMRiQ5RCW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni373 – 392RCLAdd BLAST20

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOVERGENiHBG005957
InParanoidiQ5RCW5
KOiK03984
OMAiFFLPDEG
OrthoDBiEOG091G0ION
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RCW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSSVSWGIL LLAGLCCLVP VSLAEDPQGD AAQKTDTSHH DQDHPTFNKI
60 70 80 90 100
TPNLAEFAFS LYRQLAHQSN STNIFFSPVS IATAFAMLSL GTKADTHSEI
110 120 130 140 150
LEGLHFNLTE IPEAQVHEGF QELLRTLNQP DSQLQLTTGN GLFLNESLKL
160 170 180 190 200
VDKFLEDVKK LYHSDAFTVN FGDTEEAKKQ INDYVEKGTQ GKIVDLVKEL
210 220 230 240 250
DRDTVFALVN YIFFKGKWER PFEVKDTKEE DFHVDEVTTV KVPMMRRLGM
260 270 280 290 300
FNIHYCEKLS SWVLLMKYLG NATAIFFLPD EGKLQHLENE LTHDIITKFL
310 320 330 340 350
ENENRRSASL HLPKLSITGT YDLKRVLGQL GITKVFSNGA DLSGVTEEAP
360 370 380 390 400
LKLSKAVHKA VLTIDEKGTE AAGAMFLEAI PMSIPPEVKF NKPFVFLMIE
410
QNTKSPLFVG KVVNPTQK
Length:418
Mass (Da):46,861
Last modified:December 21, 2004 - v1
Checksum:iBF93D2080AEDBE56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289N → D in CAH89581 (Ref. 1) Curated1
Sequence conflicti305R → RS in CAH89581 (Ref. 1) Curated1
Sequence conflicti305R → RS in CAI29594 (Ref. 1) Curated1
Sequence conflicti332I → T in CAH89581 (Ref. 1) Curated1
Sequence conflicti396 – 404FLMIEQNTK → CLISVFQNA in CAI29594 (Ref. 1) Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857285 mRNA Translation: CAH89581.1
CR858153 mRNA Translation: CAH90392.1
CR925936 mRNA Translation: CAI29594.1
RefSeqiNP_001124697.1, NM_001131225.2
NP_001128914.1, NM_001135442.1
XP_009247699.1, XM_009249424.1
XP_009247700.1, XM_009249425.1
XP_009247701.1, XM_009249426.1
XP_009247702.1, XM_009249427.1
XP_009247703.1, XM_009249428.1
XP_009247704.1, XM_009249429.1
XP_009247705.1, XM_009249430.1
XP_009247706.1, XM_009249431.1
XP_009247707.1, XM_009249432.1
XP_009247708.1, XM_009249433.1
UniGeneiPab.19640

Genome annotation databases

EnsembliENSPPYT00000007214; ENSPPYP00000006940; ENSPPYG00000006103
GeneIDi100171544
100189861
KEGGipon:100171544

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857285 mRNA Translation: CAH89581.1
CR858153 mRNA Translation: CAH90392.1
CR925936 mRNA Translation: CAI29594.1
RefSeqiNP_001124697.1, NM_001131225.2
NP_001128914.1, NM_001135442.1
XP_009247699.1, XM_009249424.1
XP_009247700.1, XM_009249425.1
XP_009247701.1, XM_009249426.1
XP_009247702.1, XM_009249427.1
XP_009247703.1, XM_009249428.1
XP_009247704.1, XM_009249429.1
XP_009247705.1, XM_009249430.1
XP_009247706.1, XM_009249431.1
XP_009247707.1, XM_009249432.1
XP_009247708.1, XM_009249433.1
UniGeneiPab.19640

3D structure databases

ProteinModelPortaliQ5RCW5
SMRiQ5RCW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006940

Protein family/group databases

MEROPSiI04.001

Proteomic databases

PRIDEiQ5RCW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000007214; ENSPPYP00000006940; ENSPPYG00000006103
GeneIDi100171544
100189861
KEGGipon:100171544

Organism-specific databases

CTDi5265

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOVERGENiHBG005957
InParanoidiQ5RCW5
KOiK03984
OMAiFFLPDEG
OrthoDBiEOG091G0ION
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1AT_PONAB
AccessioniPrimary (citable) accession number: Q5RCW5
Secondary accession number(s): Q5NVR9, Q5RF76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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