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Entry version 86 (07 Oct 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Cullin-7

Gene

CUL7

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-7
Short name:
CUL-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUL7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002234681 – 1729Cullin-7Add BLAST1729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei371PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1607Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5RCJ3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1.

Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8.

Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.

Interacts with CUL9; leading to inhibit CUL9 activity.

Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53.

Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53.

Interacts with CUL1; the interactions seems to be mediated by FBXW8.

Interacts with OBSL1 (By similarity).

Interacts (as part of the 3M complex) with HDAC4 and HDAC5; it is negatively regulated by ANKRA2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000018598

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q5RCJ3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5RCJ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini845 – 1024DOCPROSITE-ProRule annotationAdd BLAST180

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RDJD, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5RCJ3

KEGG Orthology (KO)

More...
KOi
K10613

Database of Orthologous Groups

More...
OrthoDBi
469819at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR016024, ARM-type_fold
IPR021097, CPH_domain
IPR031223, CUL7
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR008979, Galactose-bd-like_sf
IPR014722, Rib_L2_dom2

The PANTHER Classification System

More...
PANTHERi
PTHR22771:SF3, PTHR22771:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00888, Cullin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337, APC10, 1 hit
SM00884, Cullin_Nedd8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF49785, SSF49785, 1 hit
SSF75632, SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50069, CULLIN_2, 1 hit
PS51284, DOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5RCJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE
60 70 80 90 100
GDGGSGQVDC KAEHILLWMS KDEIYANCHK MLGEDGQVIG PSQESTGEVG
110 120 130 140 150
ALDKSVLEEM ETDVKSLIQR ALRQLEECVG TIPPAPLLHT VHVLSAYASI
160 170 180 190 200
EPLTGVFKDP RVLDLLMHML SSPDYQIRWS AGRMIQALSS HDAGEGQCGE
210 220 230 240 250
EGKAGEELGR LRDSQDTVAG ASDLIRTRTQ ILLSLSQQEA IEKHLDFDSR
260 270 280 290 300
CALLALFAQA TLSEHPMSFE GIQLPQVPGR VLFSLVKRYL HVTSLLDQLN
310 320 330 340 350
DSAAEPGAQN TSAPEEWSGE RGQLELEFSM AMGTLISELV QAIRWDQASD
360 370 380 390 400
RPRSSARSPG SIFQPQLADV SPGLPATQAQ PSFRRSRHFR PRSEFASGNT
410 420 430 440 450
YALYVRDTLQ PGMRVRMLDE YEEISAGDEG EFRQSNNGVP PVQVLWESTG
460 470 480 490 500
RTYWVHWHML EILGFEEDIE DMVEADEYQG AVASRVLGRA LPAWRWRPMT
510 520 530 540 550
ELYAVPYVLP EDEDSEECEH LTLAEWWELL FFIKKLDGPD HQEVLQILQE
560 570 580 590 600
NLDGEILDDE ILAELAVPIE LAQDLLLTLP QRLNDSALRD LINCHVYKKY
610 620 630 640 650
GPEALAGNPA YPSLLEAQED VLLEAQAQAK DSEDAAKVEA KEPPSQSPNT
660 670 680 690 700
PLQRLVEGYG PAGKILLDLE QALSSEGTQE NKVKPLLLQL QRQPQPFLAL
710 720 730 740 750
MQSLDTPETN RTLHLTVLRI LKQLVDFPEA LLLPWHEAVD ACMACLRSPN
760 770 780 790 800
TDREVLQELI FFLHRLTSVS RDYAVVLNQL GARDAISKAL EKHLGKLELA
810 820 830 840 850
QELRDMVFKC EKHAHLYREL ITNILGGCIQ MVLGQIEDHR RTHRPINIPF
860 870 880 890 900
FDVFLRYLCQ GSSVEVKEDK CWEKVEVSSN PHRASKLTDR NPKTYWESNG
910 920 930 940 950
SAGSRYITLH MRQGILIRQL TLLVASEDSS YMPARVVVCG GDSTSSLHTE
960 970 980 990 1000
LNSVNVMPSA SRVILLENLT RFWPIIQIRI KRCQQGGIDT RIRGLETLGP
1010 1020 1030 1040 1050
KPTFWPVFRE QLCRHTRLFY MVRAQAWSQD MAEDRRSLLH LSSRLNGALR
1060 1070 1080 1090 1100
QEQNFADRFL PDNEAAQALG KTCWEALVSP VVQNITSPDE DGISPLGWLL
1110 1120 1130 1140 1150
DQYLECQEAV FNPQSRGPAF FSRVRRLTHL LVHVEPCEAP PPVVATPRPK
1160 1170 1180 1190 1200
GRNRSHDWSS LATRGLPSSI MRNLTRCRRA VVEKQVNNFL TSSWRDDDFV
1210 1220 1230 1240 1250
PRYCEHFNIL QNSSSELFGP RAAFLLALQN GCAGALLKLP FLKAAHVSEQ
1260 1270 1280 1290 1300
FARHIDQQIQ GSRIGGAQEM ERLAQLQQCL QAVLIFSGLE IATTFEHYYQ
1310 1320 1330 1340 1350
HYMADRLLGV VSSWLEGAVL EQIGPCFPNR LPQQMLQSLS TSKELQRQFH
1360 1370 1380 1390 1400
VYQLQQLDQE LLKLEDTEKK IQVGHGASGK EHKSEKEEEA GAAAAVDVAE
1410 1420 1430 1440 1450
GEEEEEENED LYYEGAMPEV SVLVLSRHCW PVASICHTLN PRTCLPSYLR
1460 1470 1480 1490 1500
GTLNRYSNFY NKSQSHPALE RGSQRRLQWT WLGWAELQFG NQTLHVSTVQ
1510 1520 1530 1540 1550
MWLLLYLNDL KAVSVESLLA LSGLSADMLN QAIGPLTSSR GPLDLHEQKD
1560 1570 1580 1590 1600
IPGGVLKIRD GSKEPRSRWD IVRLIPPQTY LQAEGEEGRN LEKRRNLLNC
1610 1620 1630 1640 1650
LIVRILKAHG DEGLHIDQLV CLVLEAWQKG PCPPRGLVSS LGKGSACSST
1660 1670 1680 1690 1700
DVLSCILHLL GKGTLRRHDD RPQVLSYAVP VTVMEPHTES LNPGSSGPNP
1710 1720
PLTFHTVQIR SRGVPYASCT ATQSFSTFR
Length:1,729
Mass (Da):194,424
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8901AAC72F704313
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR858277 mRNA Translation: CAH90514.1

NCBI Reference Sequences

More...
RefSeqi
NP_001125271.1, NM_001131799.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100172168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pon:100172168

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858277 mRNA Translation: CAH90514.1
RefSeqiNP_001125271.1, NM_001131799.1

3D structure databases

BMRBiQ5RCJ3
SMRiQ5RCJ3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000018598

Proteomic databases

PRIDEiQ5RCJ3

Genome annotation databases

GeneIDi100172168
KEGGipon:100172168

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9820

Phylogenomic databases

eggNOGiENOG502RDJD, Eukaryota
InParanoidiQ5RCJ3
KOiK10613
OrthoDBi469819at2759

Enzyme and pathway databases

UniPathwayiUPA00143

Family and domain databases

Gene3Di2.30.30.30, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR016024, ARM-type_fold
IPR021097, CPH_domain
IPR031223, CUL7
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR008979, Galactose-bd-like_sf
IPR014722, Rib_L2_dom2
PANTHERiPTHR22771:SF3, PTHR22771:SF3, 1 hit
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00888, Cullin, 1 hit
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM00884, Cullin_Nedd8, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49785, SSF49785, 1 hit
SSF75632, SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS50069, CULLIN_2, 1 hit
PS51284, DOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUL7_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5RCJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 21, 2004
Last modified: October 7, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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