UniProtKB - Q5RCD8 (AT1A2_PONAB)
Sodium/potassium-transporting ATPase subunit alpha-2
ATP1A2
Functioni
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity).
By similarityCatalytic activityi
- EC:7.2.2.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 374 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 714 | MagnesiumBy similarity | 1 | |
Metal bindingi | 718 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- P-type sodium:potassium-exchanging transporter activity Source: UniProtKB
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alpha-2 (EC:7.2.2.13)Short name: Na(+)/K(+) ATPase alpha-2 subunit Alternative name(s): Sodium pump subunit alpha-2 |
Gene namesi | Name:ATP1A2 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 6 – 85 | CytoplasmicSequence analysisAdd BLAST | 80 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 129 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 130 – 150 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 151 – 286 | CytoplasmicSequence analysisAdd BLAST | 136 | |
Transmembranei | 287 – 306 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 307 – 318 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 319 – 336 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 337 – 769 | CytoplasmicSequence analysisAdd BLAST | 433 | |
Transmembranei | 770 – 789 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 790 – 799 | ExtracellularSequence analysis | 10 | |
Transmembranei | 800 – 820 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 821 – 840 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 841 – 863 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 864 – 915 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 916 – 935 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 936 – 948 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 949 – 967 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 968 – 982 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 983 – 1003 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1004 – 1020 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000305983 | 1 – 5 | By similarity | 5 | |
ChainiPRO_0000305984 | 6 – 1020 | Sodium/potassium-transporting ATPase subunit alpha-2By similarityAdd BLAST | 1015 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Modified residuei | 450 | PhosphoserineBy similarity | 1 | |
Modified residuei | 496 | PhosphoserineBy similarity | 1 | |
Modified residuei | 559 | PhosphoserineBy similarity | 1 | |
Modified residuei | 570 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 587 | PhosphoserineBy similarity | 1 | |
Modified residuei | 672 | PhosphoserineBy similarity | 1 | |
Modified residuei | 826 | PhosphoserineBy similarity | 1 | |
Modified residuei | 940 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
Interacts with regulatory subunit FXYD1.
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000000749 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 80 – 82 | Interaction with phosphoinositide-3 kinaseBy similarity | 3 | |
Regioni | 212 – 231 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 212 – 230 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0203, Eukaryota |
InParanoidi | Q5RCD8 |
OrthoDBi | 388324at2759 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG
60 70 80 90 100
RKYQVDLSKG LTNQRAQDVL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI
110 120 130 140 150
LLWIGAILCF LAYGIQAAME DEPSNDNLYL GVVLAAVVIV TGCFSYYQEA
160 170 180 190 200
KSSKIMDSFK NMVPQQALVI REGEKMQINA EEVVVGDLVE VKGGDRVPAD
210 220 230 240 250
LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG
260 270 280 290 300
TARGIVIATG DRTVMGRIAT LASGLEVGRT PIAMEIEHFI QLITGVAVFP
310 320 330 340 350
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIREADT
410 420 430 440 450
TEDQSGATFD KRSPTWTALS RIAGLCNRAV FKAGQENISV SKRDTAGDAS
460 470 480 490 500
ESALLKCIEL SCGSVRKMRD RNPKVAEIPF NSTNKYQLSI HEREDSPQSH
510 520 530 540 550
VLVMKGAPER ILDRCPTILV QGKEIPLDKE MQDAFQNAYM ELGGLGERVL
560 570 580 590 600
GFCQLNLPSG KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV
610 620 630 640 650
GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPMS
660 670 680 690 700
QVNPREAKAC VVHGSDLKDM TSEQLDEILK NHTEIVFART SPQQKLVIVE
710 720 730 740 750
GCQRQGAIVA VTGDGVNDSP ALKKADIGIA MGISGSDVSK QAADMILLDD
760 770 780 790 800
NFASIVTGVE EGRLVFDNLK KSIAYTLTSN IPEITPFLLF IIANIPLPLG
810 820 830 840 850
TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNSQTDK LVNERLISMA
860 870 880 890 900
YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR TMNDLEDSYG
910 920 930 940 950
QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMKNKI
960 970 980 990 1000
LIFGLLEETA LAAFLSYCPG MGVALRMYPL KVTWWFCAFP YSLLIFIYDE
1010 1020
VRKLILRRYP GGWVEKETYY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR858333 mRNA Translation: CAH90569.1 |
RefSeqi | NP_001125304.1, NM_001131832.1 |
Genome annotation databases
GeneIDi | 100172203 |
KEGGi | pon:100172203 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR858333 mRNA Translation: CAH90569.1 |
RefSeqi | NP_001125304.1, NM_001131832.1 |
3D structure databases
AlphaFoldDBi | Q5RCD8 |
SMRi | Q5RCD8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000000749 |
Genome annotation databases
GeneIDi | 100172203 |
KEGGi | pon:100172203 |
Organism-specific databases
CTDi | 477 |
Phylogenomic databases
eggNOGi | KOG0203, Eukaryota |
InParanoidi | Q5RCD8 |
OrthoDBi | 388324at2759 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1A2_PONAB | |
Accessioni | Q5RCD8Primary (citable) accession number: Q5RCD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families