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Protein

Chitinase-3-like protein 1

Gene

CHI3L1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).By similarity

Caution

Although it belongs to the glycosyl hydrolase 18 family, Leu-167 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168ChitooligosaccharideBy similarity1
Binding sitei290ChitooligosaccharideBy similarity1
Binding sitei379ChitooligosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processApoptosis, Inflammatory response
LigandLectin

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase-3-like protein 1
Gene namesi
Name:CHI3L1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 48By similarityAdd BLAST48
ChainiPRO_000004278849 – 410Chitinase-3-like protein 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 78By similarity
Glycosylationi87N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi327 ↔ 391By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5RBP6

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000000371

Structurei

3D structure databases

ProteinModelPortaliQ5RBP6
SMRiQ5RBP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 98Chitooligosaccharide bindingBy similarity2
Regioni124 – 127Chitooligosaccharide bindingBy similarity4
Regioni231 – 234Chitooligosaccharide bindingBy similarity4
Regioni351 – 365Important for AKT1 activation and IL8 productionBy similarityAdd BLAST15

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
HOVERGENiHBG011684
InParanoidiQ5RBP6
KOiK17523

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR028538 CHI3L1
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11177:SF202 PTHR11177:SF202, 1 hit
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RBP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVKAAQTGI WASQGQSIRV VGFQAQTAHR AICLLGFVVL VLLQCCSAYK
60 70 80 90 100
LVCYYTSWSQ YREGDGSCFP DAIDRFLCTH IIYSFANISN DHIDTWEWND
110 120 130 140 150
VTLYGMLNTL KNRNPNLKTL LSVGGWNFGS QRFSNIASNT QSRRTFIKSV
160 170 180 190 200
PPFLRTHGFD GLDLAWLYPG QRDKQHFTTL IKEMRAEFIK EAQPGKKQLL
210 220 230 240 250
LSAAVSAGKV TIDSSYDIAK ISQHLDFISI MTYDFHGAWR GTTGHHSPLF
260 270 280 290 300
RGQEDASPDR FSNTDYAVGY MLRLEAPASK LVMGIPTFGR SFTLASSETG
310 320 330 340 350
VGAPISGPGI PGRFTKEAGT LAYYEICDFL RGATVHRILG QQVPYATKGN
360 370 380 390 400
QWVGYDDQES VKSKVQYLKE RQLAGAMVWA LDLDDFQGSF CGQDLRFPLT
410
NAIKDALAAT
Length:410
Mass (Da):45,561
Last modified:December 21, 2004 - v1
Checksum:iDA951C7769571754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858592 mRNA Translation: CAH90814.1
RefSeqiNP_001125463.1, NM_001131991.1

Genome annotation databases

GeneIDi100172371
KEGGipon:100172371

Similar proteinsi

Entry informationi

Entry nameiCH3L1_PONAB
AccessioniPrimary (citable) accession number: Q5RBP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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