UniProtKB - Q5RAL8 (OX2G_PONAB)
Protein
OX-2 membrane glycoprotein
Gene
CD200
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).By similarity
GO - Biological processi
- negative regulation of macrophage activation Source: InterPro
- regulation of immune response Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: OX-2 membrane glycoproteinAlternative name(s): CD_antigen: CD200 |
Gene namesi | Name:CD200 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 236 | ExtracellularSequence analysisAdd BLAST | 206 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 269 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000250714 | 31 – 269 | OX-2 membrane glycoproteinAdd BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 121 | PROSITE-ProRule annotation | ||
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 118 ↔ 136 | PROSITE-ProRule annotation | ||
Glycosylationi | 157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 214 | PROSITE-ProRule annotation | ||
Glycosylationi | 181 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 190 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000015150 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 141 | Ig-like V-typeAdd BLAST | 111 | |
Domaini | 142 – 232 | Ig-like C2-typeAdd BLAST | 91 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S5DU, Eukaryota |
InParanoidi | Q5RAL8 |
OrthoDBi | 1161268at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR033321, CD200 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR013151, Immunoglobulin |
PANTHERi | PTHR46841:SF3, PTHR46841:SF3, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5RAL8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERLVIRMPF CHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK
60 70 80 90 100
CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINIAQLG
110 120 130 140 150
LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK
160 170 180 190 200
FSEDHLNTTC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH
210 220 230 240 250
IKDPKNQVGK EAICQVLHLG TVTDFKQTVN KGYWFSVPLL LSIVSLVTLL
260
VLISILLYWK RHRNQDREP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR858997 mRNA Translation: CAH91192.1 |
RefSeqi | NP_001125699.1, NM_001132227.1 |
Genome annotation databases
GeneIDi | 100172623 |
KEGGi | pon:100172623 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR858997 mRNA Translation: CAH91192.1 |
RefSeqi | NP_001125699.1, NM_001132227.1 |
3D structure databases
SMRi | Q5RAL8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000015150 |
Genome annotation databases
GeneIDi | 100172623 |
KEGGi | pon:100172623 |
Organism-specific databases
CTDi | 4345 |
Phylogenomic databases
eggNOGi | ENOG502S5DU, Eukaryota |
InParanoidi | Q5RAL8 |
OrthoDBi | 1161268at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR033321, CD200 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR013151, Immunoglobulin |
PANTHERi | PTHR46841:SF3, PTHR46841:SF3, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OX2G_PONAB | |
Accessioni | Q5RAL8Primary (citable) accession number: Q5RAL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |