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Protein

WW domain-containing oxidoreductase

Gene

WWOX

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei260SubstrateBy similarity1
Active sitei293Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi131 – 137NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Wnt signaling pathway
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Gene namesi
Name:WWOX
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548171 – 414WW domain-containing oxidoreductaseAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei33PhosphotyrosineBy similarity1
Modified residuei287Phosphotyrosine; by TNK2By similarity1

Post-translational modificationi

Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation (By similarity).By similarity
Ubiquitinated when phosphorylated by TNK2, leading to its degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN (By similarity). Interacts with TNK2 (By similarity). Interacts with TMEM207 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000008550

Structurei

3D structure databases

ProteinModelPortaliQ5R9W5
SMRiQ5R9W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 49WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini57 – 90WW 2PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 414Interaction with MAPTBy similarityAdd BLAST290
Regioni209 – 273Mediates targeting to the mitochondriaBy similarityAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 55Nuclear localization signalBy similarity6

Domaini

The WW 1 domain mediates interaction with TP53, TP73, TFAP2C, LITAF and WBP1.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410INSS Eukaryota
COG5021 LUCA
HOVERGENiHBG078800
InParanoidiQ5R9W5
KOiK19329

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF00397 WW, 2 hits
PRINTSiPR00081 GDHRDH
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q5R9W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG
60 70 80 90 100
KRKRVAGDLP YGWEQGTDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK
110 120 130 140 150
PTTRQRYDGS TTALEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH
160 170 180 190 200
VILACRNMAR ASEAVSRILE EWHKAKVEAV TLDLALLRSV QHFAEAFKAK
210 220 230 240 250
NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV QLLQDVLCRS
260 270 280 290 300
APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN
310 320 330 340 350
VLFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK
360 370 380 390 400
SMQQGAATTV YCAAAPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL
410
SERLIQERLG SQSG
Length:414
Mass (Da):46,513
Last modified:December 21, 2004 - v1
Checksum:iE7F22B2916735479
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2NRJ9H2NRJ9_PONAB
WW domain-containing oxidoreductase
WWOX CR201_G0015446
414Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859266 mRNA Translation: CAH91445.1
RefSeqiNP_001125849.1, NM_001132377.1
UniGeneiPab.10156

Genome annotation databases

GeneIDi100172779
KEGGipon:100172779

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859266 mRNA Translation: CAH91445.1
RefSeqiNP_001125849.1, NM_001132377.1
UniGeneiPab.10156

3D structure databases

ProteinModelPortaliQ5R9W5
SMRiQ5R9W5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000008550

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172779
KEGGipon:100172779

Organism-specific databases

CTDi51741

Phylogenomic databases

eggNOGiENOG410INSS Eukaryota
COG5021 LUCA
HOVERGENiHBG078800
InParanoidiQ5R9W5
KOiK19329

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF00397 WW, 2 hits
PRINTSiPR00081 GDHRDH
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiWWOX_PONAB
AccessioniPrimary (citable) accession number: Q5R9W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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