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Protein

Leucine-rich repeat-containing protein 41

Gene

LRRC41

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Gene namesi
Name:LRRC41
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926581 – 812Leucine-rich repeat-containing protein 41Add BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei327PhosphothreonineBy similarity1
Modified residuei357PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5R9H2

Interactioni

Subunit structurei

Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, ELOB and ELOC (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5R9H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati487 – 507LRR 1Add BLAST21
Repeati518 – 530LRR 2Add BLAST13
Repeati531 – 555LRR 3Add BLAST25
Repeati613 – 635LRR 4Add BLAST23
Repeati636 – 659LRR 5Add BLAST24
Repeati701 – 728LRR 6Add BLAST28
Repeati731 – 752LRR 7Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 54Interaction with Elongin BC complexBy similarity10

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x3-C-x3-[AILV].By similarity

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG102701
InParanoidiQ5R9H2
KOiK10347

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR026137 Leu_rpt_41
IPR032675 LRR_dom_sf
PANTHERiPTHR15354 PTHR15354, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R9H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDRRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMASRRKSEA KQMPRAAPAA RVTRRSTQES LTAGGTDLKR ELHPPATSHE
360 370 380 390 400
APGTKRSPSA PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA
410 420 430 440 450
RTRQGPGAES EDLYDFVFIV AGEKEDGEEM EIGEVACGAL DGSDPSCLGL
460 470 480 490 500
PALEASQRFR SISTLELFTV PLSTEAALTL CRLLSSWVSL ESLTLSFNGL
510 520 530 540 550
GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT RAIVRALPLL
560 570 580 590 600
RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA
610 620 630 640 650
QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS
660 670 680 690 700
FHDMNLADCQ SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG
710 720 730 740 750
NSTLKGLRLP GNRLGNAGLL ALADVFSEDS SSSLCQLDIS SNCIKPDGLL
760 770 780 790 800
EFAKRLERWG RGAFGHLRLF QNWLDQDAVT AREAIRRLRA TCHVVSDSWD
810
SSQAFADYVS TM
Length:812
Mass (Da):88,623
Last modified:December 21, 2004 - v1
Checksum:i362E250C08350D1F
GO

Sequence cautioni

The sequence CAH92369 differs from that shown. Reason: Frameshift at position 800.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti482R → H in CAH92369 (Ref. 1) Curated1
Sequence conflicti497F → Y in CAH92369 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859416 mRNA Translation: CAH91588.1
CR860227 mRNA Translation: CAH92369.1 Frameshift.
RefSeqiNP_001125935.1, NM_001132463.1

Genome annotation databases

GeneIDi100172869
KEGGipon:100172869

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859416 mRNA Translation: CAH91588.1
CR860227 mRNA Translation: CAH92369.1 Frameshift.
RefSeqiNP_001125935.1, NM_001132463.1

3D structure databases

ProteinModelPortaliQ5R9H2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5R9H2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172869
KEGGipon:100172869

Organism-specific databases

CTDi10489

Phylogenomic databases

HOVERGENiHBG102701
InParanoidiQ5R9H2
KOiK10347

Enzyme and pathway databases

UniPathwayi
UPA00143

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR026137 Leu_rpt_41
IPR032675 LRR_dom_sf
PANTHERiPTHR15354 PTHR15354, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLRC41_PONAB
AccessioniPrimary (citable) accession number: Q5R9H2
Secondary accession number(s): Q5R791
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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