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UniProtKB - Q5R9E0 (ACY2_PONAB)
Protein
Aspartoacylase
Gene
ASPA
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids (By similarity).
By similarityCatalytic activityi
- EC:3.5.1.15
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 21 | ZincBy similarity | 1 | |
Metal bindingi | 24 | ZincBy similarity | 1 | |
Binding sitei | 63 | SubstrateBy similarity | 1 | |
Metal bindingi | 116 | ZincBy similarity | 1 | |
Active sitei | 178 | By similarity | 1 | |
Binding sitei | 178 | SubstrateBy similarity | 1 | |
Binding sitei | 288 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- aspartoacylase activity Source: UniProtKB-EC
- hydrolase activity, acting on ester bonds Source: InterPro
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ASPA |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000290195 | 1 – 313 | AspartoacylaseAdd BLAST | 313 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000008799 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 71 | Substrate bindingBy similarity | 2 | |
Regioni | 164 – 168 | Substrate bindingBy similarity | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QRAK, Eukaryota |
InParanoidi | Q5R9E0 |
Family and domain databases
HAMAPi | MF_00704, Aspartoacylase, 1 hit |
InterProi | View protein in InterPro IPR016708, Aspartoacylase IPR007036, Aste_AspA |
Pfami | View protein in Pfam PF04952, AstE_AspA, 1 hit |
PIRSFi | PIRSF018001, Aspartoacylase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R9E0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSCHIAEEP IQKVAIFGGT HGNELTGVFL VKHWLENGAE IQRTGLEVKP
60 70 80 90 100
FITNPRAVKK CTRYIDCDLN RIFDLENLGK KMSEDLPYEV RRAQEINHLF
110 120 130 140 150
GPKDSEDSYD IIFDLHNTTS NMGCTLILED SRNNFLIQMF HYIKTSLAPL
160 170 180 190 200
PCYVYLIEHP SLKYATTRSI AKYPVGIEVG PQPQGVLRAD ILDQMRKMIK
210 220 230 240 250
HALDFIHHFN EGKEFPPCAI EVYKIIEKVD YPRDENGEIA AVIHPNLQDQ
260 270 280 290 300
DWKPLHPGDP MFLTLDGKTI PLGGDCTVYP VFVNEAAYYE KKEAFAKTTK
310
LTLNAKSIRC SLH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR859449 mRNA Translation: CAH91620.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR859449 mRNA Translation: CAH91620.1 |
3D structure databases
SMRi | Q5R9E0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000008799 |
Phylogenomic databases
eggNOGi | ENOG502QRAK, Eukaryota |
InParanoidi | Q5R9E0 |
Family and domain databases
HAMAPi | MF_00704, Aspartoacylase, 1 hit |
InterProi | View protein in InterPro IPR016708, Aspartoacylase IPR007036, Aste_AspA |
Pfami | View protein in Pfam PF04952, AstE_AspA, 1 hit |
PIRSFi | PIRSF018001, Aspartoacylase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACY2_PONAB | |
Accessioni | Q5R9E0Primary (citable) accession number: Q5R9E0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | August 12, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families