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UniProtKB - Q5R8M3 (S35B4_PONAB)
Protein
UDP-xylose and UDP-N-acetylglucosamine transporter
Gene
SLC35B4
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
By similarityGO - Molecular functioni
- UDP-N-acetylglucosamine transmembrane transporter activity Source: Ensembl
- UDP-xylose transmembrane transporter activity Source: Ensembl
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- regulation of gluconeogenesis Source: Ensembl
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-xylose and UDP-N-acetylglucosamine transporterAlternative name(s): Solute carrier family 35 member B4 |
Gene namesi | Name:SLC35B4 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 229 – 249 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 251 – 267 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213388 | 1 – 331 | UDP-xylose and UDP-N-acetylglucosamine transporterAdd BLAST | 331 |
Structurei
3D structure databases
AlphaFoldDBi | Q5R8M3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q5R8M3 |
OMAi | NYAFDFN |
OrthoDBi | 1209974at2759 |
TreeFami | TF312926 |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
PANTHERi | PTHR10778, PTHR10778, 1 hit |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5R8M3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF
60 70 80 90 100
EADLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS
110 120 130 140 150
LIANMILGII ILKKRYSIFK YTSIALVSVG IFICTFMSAK QVTSQSSLSE
160 170 180 190 200
NDGFQAFVWW LLGIGALTFA LLMSARMGLF QETLYKRFGK HSKEALFYNH
210 220 230 240 250
ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW FYLLMNIITQ
260 270 280 290 300
YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
310 320 330
LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5URC8 | A0A8I5URC8_PONAB | UDP-xylose and UDP-N-acetylglucosam... | SLC35B4 | 319 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR859728 mRNA Translation: CAH91887.1 |
RefSeqi | NP_001126093.1, NM_001132621.1 |
Genome annotation databases
Ensembli | ENSPPYT00000021007; ENSPPYP00000020214; ENSPPYG00000018016 |
GeneIDi | 100173046 |
KEGGi | pon:100173046 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR859728 mRNA Translation: CAH91887.1 |
RefSeqi | NP_001126093.1, NM_001132621.1 |
3D structure databases
AlphaFoldDBi | Q5R8M3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000020214 |
Genome annotation databases
Ensembli | ENSPPYT00000021007; ENSPPYP00000020214; ENSPPYG00000018016 |
GeneIDi | 100173046 |
KEGGi | pon:100173046 |
Organism-specific databases
CTDi | 84912 |
Phylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q5R8M3 |
OMAi | NYAFDFN |
OrthoDBi | 1209974at2759 |
TreeFami | TF312926 |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
PANTHERi | PTHR10778, PTHR10778, 1 hit |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35B4_PONAB | |
Accessioni | Q5R8M3Primary (citable) accession number: Q5R8M3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families