UniProtKB - Q5R8A5 (PA24A_PONAB)
Protein
Cytosolic phospholipase A2
Gene
PLA2G4A
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity).By similarity
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+EC:3.1.1.4
- EC:3.1.1.5
Activity regulationi
Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 40 | Calcium 1By similarity | 1 | |
Metal bindingi | 40 | Calcium 2By similarity | 1 | |
Metal bindingi | 41 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 43 | Calcium 1By similarity | 1 | |
Metal bindingi | 43 | Calcium 2By similarity | 1 | |
Metal bindingi | 65 | Calcium 1By similarity | 1 | |
Metal bindingi | 93 | Calcium 2By similarity | 1 | |
Metal bindingi | 94 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 95 | Calcium 2By similarity | 1 | |
Active sitei | 228 | NucleophileBy similarity | 1 | |
Active sitei | 549 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium ion binding Source: UniProtKB
- lysophospholipase activity Source: UniProtKB-EC
- phospholipase A2 activity Source: UniProtKB-EC
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC
GO - Biological processi
- phospholipid catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PLA2G4A Synonyms:CPLA2, PLA2G4 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Other locations
- Cytoplasm By similarity
- Cytoplasmic vesicle By similarity
Note: Translocates to membrane vesicles in a calcium-dependent fashion.By similarity
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesiclePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000345134 | 1 – 749 | Cytosolic phospholipase A2Add BLAST | 749 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 268 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineBy similarity | 1 | |
Modified residuei | 435 | PhosphoserineBy similarity | 1 | |
Modified residuei | 437 | PhosphoserineBy similarity | 1 | |
Modified residuei | 505 | Phosphoserine; by MAPKBy similarity | 1 | |
Modified residuei | 515 | PhosphoserineBy similarity | 1 | |
Cross-linki | 541 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 606 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 727 | PhosphoserineBy similarity | 1 | |
Modified residuei | 729 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Activated by phosphorylation at both Ser-505 and Ser-727.By similarity
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PRIDEi | Q5R8A5 |
Interactioni
Subunit structurei
Interacts with KAT5.
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000000461 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 106 | C2PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 140 – 740 | PLA2cPROSITE-ProRule annotationAdd BLAST | 601 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 178 | Phospholipid bindingBy similarityAdd BLAST | 178 |
Domaini
The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1012 Eukaryota KOG1325 Eukaryota ENOG410XR72 LUCA |
HOGENOMi | HOG000115420 |
InParanoidi | Q5R8A5 |
KOi | K16342 |
OrthoDBi | 302848at2759 |
Family and domain databases
CDDi | cd04036 C2_cPLA2, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR041847 C2_cPLA2 IPR000008 C2_dom IPR035892 C2_domain_sf IPR002642 LysoPLipase_cat_dom |
Pfami | View protein in Pfam PF00168 C2, 1 hit PF01735 PLA2_B, 1 hit |
SMARTi | View protein in SMART SM00239 C2, 1 hit SM00022 PLAc, 1 hit |
SUPFAMi | SSF52151 SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50004 C2, 1 hit PS51210 PLA2C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R8A5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFIDPYQHI IVEHQYSHKF TVVVLCATKV TKGAFGDMLD TPDPYVELFI
60 70 80 90 100
STTPDSRKRT RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE
110 120 130 140 150
TLGTATFPVS SMKVGEKKEV PFIFNQVTEM ILEMSLEVCS CPDLRFSMAL
160 170 180 190 200
CDQEKTFRQQ RKEHIRESMK KLLGPKNSEG LHSARDVPVV AILGSGGGFR
210 220 230 240 250
AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH PDFPEKGPEE
260 270 280 290 300
INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG
310 320 330 340 350
ETLIHNRMNT TLSSLKEKVN TAQCPLPLFT CLHVKPDVSE LMFADWVEFS
360 370 380 390 400
PYEIGMAKYG TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL
410 420 430 440 450
FNRVLGVSGS QSRGSTMEEE LENITTKHIV SNDSSDSDDE SHEPKGTENE
460 470 480 490 500
DAGSDYQSDN QASWIHRMIM ALVSDSALFN TREGRAGKVH NFMLGLNLNT
510 520 530 540 550
SYPLSPLSDF ATQDSFDDDE LDAAVADPDE FERIYEPLDV KSKKIHVVDS
560 570 580 590 600
GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDSSPPFKEL LLAEKWAKMN
610 620 630 640 650
KLPFPKIDPY VFDREGLKEC YVFKPKNPDM EKDCPTIIHF VLANINFRKY
660 670 680 690 700
KAPGVPRETE EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMHFN
710 720 730 740
TLNNIDVIKE AMVESIEYRR QNPSRCSVSL SNVEARRFFN KEFLSKPKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR859848 mRNA Translation: CAH92005.1 |
RefSeqi | NP_001126164.1, NM_001132692.1 |
Genome annotation databases
GeneIDi | 100173125 |
KEGGi | pon:100173125 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR859848 mRNA Translation: CAH92005.1 |
RefSeqi | NP_001126164.1, NM_001132692.1 |
3D structure databases
SMRi | Q5R8A5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000000461 |
Proteomic databases
PRIDEi | Q5R8A5 |
Genome annotation databases
GeneIDi | 100173125 |
KEGGi | pon:100173125 |
Organism-specific databases
CTDi | 5321 |
Phylogenomic databases
eggNOGi | KOG1012 Eukaryota KOG1325 Eukaryota ENOG410XR72 LUCA |
HOGENOMi | HOG000115420 |
InParanoidi | Q5R8A5 |
KOi | K16342 |
OrthoDBi | 302848at2759 |
Family and domain databases
CDDi | cd04036 C2_cPLA2, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR041847 C2_cPLA2 IPR000008 C2_dom IPR035892 C2_domain_sf IPR002642 LysoPLipase_cat_dom |
Pfami | View protein in Pfam PF00168 C2, 1 hit PF01735 PLA2_B, 1 hit |
SMARTi | View protein in SMART SM00239 C2, 1 hit SM00022 PLAc, 1 hit |
SUPFAMi | SSF52151 SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50004 C2, 1 hit PS51210 PLA2C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PA24A_PONAB | |
Accessioni | Q5R8A5Primary (citable) accession number: Q5R8A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 8, 2019 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |