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Protein

E3 ubiquitin-protein ligase NRDP1

Gene

RNF41

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri78 – 138SIAH-type; degeneratePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Autophagy, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase NRDP1 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 41
RING-type E3 ubiquitin transferase NRDP1Curated
Gene namesi
Name:RNF41
Synonyms:NRDP1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002900071 – 317E3 ubiquitin-protein ligase NRDP1Add BLAST317

Post-translational modificationi

Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with USP8, ERBB3, PRKN, BIRC6, CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with CLEC16A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005297

Structurei

3D structure databases

ProteinModelPortaliQ5R7T5
SMRiQ5R7T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri78 – 138SIAH-type; degeneratePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ISDX Eukaryota
ENOG410XNN7 LUCA
GeneTreeiENSGT00530000063647
HOVERGENiHBG053154
InParanoidiQ5R7T5
KOiK11981
OMAiSRQPTCP
OrthoDBiEOG091G0BKR
TreeFamiTF351947

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR015036 NRDP1
IPR037255 NRDP1_C
IPR008974 TRAF-like
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR013010 Znf_SIAH
PfamiView protein in Pfam
PF08941 USP8_interact, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF160088 SSF160088, 1 hit
SSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS51081 ZF_SIAH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R7T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ
60 70 80 90 100
QTCPVDRSVV TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM
110 120 130 140 150
SHLSDCEHNP KRPVTCEQGC GLEMPKDELP NHNCIKHLRS VVQQQQTRIA
160 170 180 190 200
ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI RSVNPNLQNL EETIEYNEIL
210 220 230 240 250
EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA SIVNELIENA
260 270 280 290 300
HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM
310
VQEPGLVMIF AHGVEEI
Length:317
Mass (Da):35,905
Last modified:December 21, 2004 - v1
Checksum:i46AE87AF8BE1A369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860024 mRNA Translation: CAH92175.1
RefSeqiNP_001126274.1, NM_001132802.1
XP_009246169.1, XM_009247894.1
XP_009246170.1, XM_009247895.1
UniGeneiPab.5407

Genome annotation databases

EnsembliENSPPYT00000005505; ENSPPYP00000005297; ENSPPYG00000004649
GeneIDi100173246
KEGGipon:100173246

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860024 mRNA Translation: CAH92175.1
RefSeqiNP_001126274.1, NM_001132802.1
XP_009246169.1, XM_009247894.1
XP_009246170.1, XM_009247895.1
UniGeneiPab.5407

3D structure databases

ProteinModelPortaliQ5R7T5
SMRiQ5R7T5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005297

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000005505; ENSPPYP00000005297; ENSPPYG00000004649
GeneIDi100173246
KEGGipon:100173246

Organism-specific databases

CTDi10193

Phylogenomic databases

eggNOGiENOG410ISDX Eukaryota
ENOG410XNN7 LUCA
GeneTreeiENSGT00530000063647
HOVERGENiHBG053154
InParanoidiQ5R7T5
KOiK11981
OMAiSRQPTCP
OrthoDBiEOG091G0BKR
TreeFamiTF351947

Enzyme and pathway databases

UniPathwayi
UPA00143

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR015036 NRDP1
IPR037255 NRDP1_C
IPR008974 TRAF-like
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR013010 Znf_SIAH
PfamiView protein in Pfam
PF08941 USP8_interact, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF160088 SSF160088, 1 hit
SSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS51081 ZF_SIAH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNF41_PONAB
AccessioniPrimary (citable) accession number: Q5R7T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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