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Protein

Ras-related protein Rab-5C

Gene

RAB5C

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36GTPBy similarity9
Nucleotide bindingi47 – 53GTPBy similarity7
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4
Nucleotide bindingi164 – 166GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Gene namesi
Name:RAB5C
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002767681 – 216Ras-related protein Rab-5CAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Interactioni

Subunit structurei

Binds EEA1.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000009444

Structurei

3D structure databases

ProteinModelPortaliQ5R7L7
SMRiQ5R7L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 58Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOVERGENiHBG009351
InParanoidiQ5R7L7
KOiK07889
OMAiLIKAKHW
OrthoDBiEOG091G0HKN
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R7L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA TGAPGRNRGV
210
DLQENNPASR SQCCSN
Length:216
Mass (Da):23,483
Last modified:December 21, 2004 - v1
Checksum:iAA42096C6EED77ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860097 mRNA Translation: CAH92243.1
RefSeqiNP_001127529.1, NM_001134057.1
UniGeneiPab.17478

Genome annotation databases

EnsembliENSPPYT00000009823; ENSPPYP00000009444; ENSPPYG00000008398
GeneIDi100174605
KEGGipon:100174605

Similar proteinsi

Entry informationi

Entry nameiRAB5C_PONAB
AccessioniPrimary (citable) accession number: Q5R7L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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