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UniProtKB - Q5R7B1 (CLP1L_PONAB)
Protein
Cleft lip and palate transmembrane protein 1-like protein
Gene
CLPTM1L
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Enhances cisplatin-mediated apoptosis, when overexpressed.
By similarityGO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Cleft lip and palate transmembrane protein 1-like proteinShort name: CLPTM1-like protein |
Gene namesi | Name:CLPTM1L |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 11 – 31 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 284 | ExtracellularSequence analysisAdd BLAST | 253 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 306 – 324 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 325 – 342 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 343 – 346 | ExtracellularSequence analysis | 4 | |
Transmembranei | 347 – 364 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 365 – 402 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 403 – 423 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 428 | ExtracellularSequence analysis | 5 | |
Transmembranei | 429 – 449 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 450 – 538 | CytoplasmicSequence analysisAdd BLAST | 89 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331302 | 1 – 538 | Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST | 538 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinStructurei
Family & Domainsi
Sequence similaritiesi
Belongs to the CLPTM1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2489, Eukaryota |
InParanoidi | Q5R7B1 |
OMAi | FVSSIHM |
OrthoDBi | 1106937at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008429, CLPTM1 IPR030434, CLPTM1L |
PANTHERi | PTHR21347, PTHR21347, 1 hit PTHR21347:SF12, PTHR21347:SF12, 1 hit |
Pfami | View protein in Pfam PF05602, CLPTM1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R7B1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR
60 70 80 90 100
PKLQLSVYTT TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGVLPWHD GKQVHLVSPL TTYMVPKPEE INLLTGESDT
160 170 180 190 200
QQIEAEKKPT SALDEPVSHW RPRLALNVMA DNFVFDGSSL PADVHRYMKM
210 220 230 240 250
IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS YDKVSLGRLR
260 270 280 290 300
FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF
310 320 330 340 350
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL
360 370 380 390 400
VPAGVGAAIE LWKVKKALKM TILWRGLMPE FELGTYSESE RKTEEYDTQA
410 420 430 440 450
MKYLSYLLYP LCVGGAVYSL LNIKYKSWYS WLINSFVNGV YAFGFLFMLP
460 470 480 490 500
QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD VFAFIITMPT SHRLACFRDD
510 520 530
VVFLVYLYQR WLYPVDKRRV NEFGESYEEK AARAPHTD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860207 mRNA Translation: CAH92349.1 |
RefSeqi | NP_001126382.1, NM_001132910.1 |
Genome annotation databases
GeneIDi | 100173363 |
KEGGi | pon:100173363 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860207 mRNA Translation: CAH92349.1 |
RefSeqi | NP_001126382.1, NM_001132910.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000017110 |
Genome annotation databases
GeneIDi | 100173363 |
KEGGi | pon:100173363 |
Organism-specific databases
CTDi | 81037 |
Phylogenomic databases
eggNOGi | KOG2489, Eukaryota |
InParanoidi | Q5R7B1 |
OMAi | FVSSIHM |
OrthoDBi | 1106937at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008429, CLPTM1 IPR030434, CLPTM1L |
PANTHERi | PTHR21347, PTHR21347, 1 hit PTHR21347:SF12, PTHR21347:SF12, 1 hit |
Pfami | View protein in Pfam PF05602, CLPTM1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLP1L_PONAB | |
Accessioni | Q5R7B1Primary (citable) accession number: Q5R7B1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | December 21, 2004 | |
Last modified: | September 29, 2021 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families