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Entry version 82 (11 Dec 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Proteasome adapter and scaffold protein ECM29

Gene

ECPAS

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome adapter and scaffold protein ECM29
Alternative name(s):
Proteasome-associated protein ECM29 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECPAS
Synonyms:ECM29, KIAA0368
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Nucleus, Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000212561‹1 – 1810Proteasome adapter and scaffold protein ECM29Add BLAST›1810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei795PhosphoserineBy similarity1
Modified residuei801PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1004Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5R6J0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Non-stoichiometric component of the proteasome; associates with the 26S proteasome.

Interacts (via N-terminus) with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1.

Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10, MYO10 and ARF6.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000021840

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 36HEAT 1Add BLAST36
Repeati78 – 115HEAT 2Add BLAST38
Repeati133 – 176HEAT 3Add BLAST44
Repeati297 – 333HEAT 4Add BLAST37
Repeati358 – 397HEAT 5Add BLAST40
Repeati400 – 437HEAT 6Add BLAST38
Repeati440 – 478HEAT 7Add BLAST39
Repeati654 – 691HEAT 8Add BLAST38
Repeati692 – 730HEAT 9Add BLAST39
Repeati754 – 791HEAT 10Add BLAST38
Repeati800 – 839HEAT 11Add BLAST40
Repeati841 – 878HEAT 12Add BLAST38
Repeati902 – 940HEAT 13Add BLAST39
Repeati946 – 983HEAT 14Add BLAST38
Repeati984 – 1021HEAT 15Add BLAST38
Repeati1083 – 1120HEAT 16Add BLAST38
Repeati1123 – 1160HEAT 17Add BLAST38
Repeati1165 – 1202HEAT 18Add BLAST38
Repeati1214 – 1252HEAT 19Add BLAST39
Repeati1256 – 1294HEAT 20Add BLAST39
Repeati1319 – 1357HEAT 21Add BLAST39
Repeati1361 – 1398HEAT 22Add BLAST38
Repeati1488 – 1525HEAT 23Add BLAST38
Repeati1529 – 1566HEAT 24Add BLAST38
Repeati1576 – 1613HEAT 25Add BLAST38
Repeati1617 – 1654HEAT 26Add BLAST38
Repeati1750 – 1793HEAT 27Add BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ECM29 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0915 Eukaryota
ENOG410XPYT LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5R6J0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024372 Ecm29
IPR032878 Vac14_Fab1-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23346:SF19 PTHR23346:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13001 Ecm29, 1 hit
PF12755 Vac14_Fab1_bd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q5R6J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ISKFLPPVLL KLSSTQEGVR KKVMELLVHL NKRIKSPPKI QLPVETLLVQ
60 70 80 90 100
YQDPAAVSFV TNFTIIYVKM GYPRLPVEKQ CELAPTLLTA MEGKPRPQQD
110 120 130 140 150
SLMHLLIPTL FHMKYPVESS KSASPFNLAE KPKTVQLLLD FMLDVLLMPY
160 170 180 190 200
GYVLNESQSR QNSSSAQGSS SNSGGGSGIP QPPPGMSFYA AKRVIGDNPW
210 220 230 240 250
TPEQLEQCKL GIVKFIEAEQ VPELEAVLHL VIASSDTRHS VATAADLELK
260 270 280 290 300
SKQSLIDWNN PAIINKMYKV YLGDIPLKTK EGAVLKPELK RDPVSTRVKL
310 320 330 340 350
KIVPHLLRSR QAAETFPANI QVVYDGLFGT NTNSKLRTLS LQFVHHICIT
360 370 380 390 400
CPEIKIKPLG PMLLNGLTKL INEYKEDPKL LSMAYSAVGK LSSRMPHLFT
410 420 430 440 450
KDIALVQQLF EALCKEEPET RLAIQEALSM MVGAYSTLEG AQRTLMEALV
460 470 480 490 500
ASYLIKPEVQ VRQVAVKFAS TVFPSDHIPS RYLLLLAAGD PREEVHGEAQ
510 520 530 540 550
RVLRCLPGRN RKESTSEQMP SFPEMVYYIQ EKASHRMKTP VKYMTGTTVL
560 570 580 590 600
PFNPAAFGEI VLYLRMCLAH SAGVVPTSQS LADMQDHAPA IGRYIRTLMS
610 620 630 640 650
SGQTAPSSSN KSGETNPVQI YIGLLQQLLA GVGGLPVMYC LLEAVSVYPE
660 670 680 690 700
KLATKFVDKT EWIKSLMNSS KEEMRELAAL FYSVVVSTVS GNELKSMIEQ
710 720 730 740 750
LIKTTKDNHS PEIQHGSLLA LGFTVGRYLA KKKMRMSEQQ DLERNADTLP
760 770 780 790 800
DQEELIQSAT ETIGSFLDST SPLLAIAACT ALGEIGRNGP LPIPSEGSGF
810 820 830 840 850
TKLHLVESLL SRIPSSKETN KMKERAIQTL GYFPVGDGDF PHQKLLLQGL
860 870 880 890 900
MDSVEAKQIE LQFTIGEAIT SAAIGTSPVA ARDAWQVTEE EYTPPAGAKV
910 920 930 940 950
NDVVPWVLDV ILNKHIISPN PHVRQAACIW LLSLVRKLST HKEVKSHLKE
960 970 980 990 1000
IQSAFVSVLS ENDELSQDVA SKGLGLVYEL GNEQDQQELV STLVETLMTG
1010 1020 1030 1040 1050
KRVKHEVSGE TVVFQGGALG KTPDGQGLST YKELCSLASD LSQPDLVYKF
1060 1070 1080 1090 1100
MNLANHHAMW NSRKGAAFGF NVIATRAGEQ LAPFLPQLVP RLYRYQFDPN
1110 1120 1130 1140 1150
LGIRQAMTSI WNALVTDKSM VDKYLKEILQ DLVKNLTSNT WRVRESSCLA
1160 1170 1180 1190 1200
LNDLLRGRPL DDIIDKLPEI WETLFRVQDD IKESVRKAAE LALKTLSKVC
1210 1220 1230 1240 1250
VKMCDPAKGA AGQRTIAALL SCLLDKGMMS PVTEVRALSI NTLVKISKSA
1260 1270 1280 1290 1300
GAMLKPHAPK LIPALLESLS VLEPQVLNYL SLRATEQEKA AMDSARLSAA
1310 1320 1330 1340 1350
KSSPMMETIN MCLQYLDVSV LGELVPRLCE LIRSGVGLGT KGGCASVIVS
1360 1370 1380 1390 1400
LTTQCPQDLT PYSGKLMSAL LSGLTDRNSV IQKSCAFAMG HLVRTSRDSS
1410 1420 1430 1440 1450
TEKLLQKLNG WYMEKEEPIY KTSCALTIHA IGRYSPDVLK NHAKEVLPLA
1460 1470 1480 1490 1500
FLGMHEAADE EKSEKEECNL WTEVWQENVP GSFGGIRLYL QELITITQKA
1510 1520 1530 1540 1550
LQSQSWKMKA QGAIAMASIA KQTSSLVPPY LGMILTALLQ GLAGRTWAGK
1560 1570 1580 1590 1600
EELLKAIACV VTAYSAELEK SVPNQPSTNE ILQAVLKECS KENLKYKIVA
1610 1620 1630 1640 1650
ISCAADVLKA TKEDRFQEFS DIVIPLIKKN SLESSGVRTT KNEEENEKEK
1660 1670 1680 1690 1700
ELQLEYLLGA FESLGKAWPR NAETQRCYRQ ELCKLMCERL KLSTWKVQLG
1710 1720 1730 1740 1750
VLQSMNAFFQ GLMLLEEEHA DPEALAEILL ETCKSITYSL ENKTYSSVRT
1760 1770 1780 1790 1800
EALSVIELLL KKLEESKQWE CLTSECRVLL IESLATMEPD SRPGLQEKAA
1810
LLKKTLENLE
Length:1,810
Mass (Da):200,260
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA1B833AE74E5E6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti878P → S in CAH90910 (Ref. 1) Curated1
Sequence conflicti1221S → P in CAH90910 (Ref. 1) Curated1
Sequence conflicti1457A → I in CAH90910 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR858699 mRNA Translation: CAH90910.1
CR860499 mRNA Translation: CAH92620.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858699 mRNA Translation: CAH90910.1
CR860499 mRNA Translation: CAH92620.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021840

Proteomic databases

PRIDEiQ5R6J0

Phylogenomic databases

eggNOGiKOG0915 Eukaryota
ENOG410XPYT LUCA
InParanoidiQ5R6J0

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024372 Ecm29
IPR032878 Vac14_Fab1-bd
PANTHERiPTHR23346:SF19 PTHR23346:SF19, 1 hit
PfamiView protein in Pfam
PF13001 Ecm29, 1 hit
PF12755 Vac14_Fab1_bd, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECM29_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5R6J0
Secondary accession number(s): Q5RBF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: December 11, 2019
This is version 82 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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