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Protein

Death domain-containing protein CRADD

Gene

CRADD

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
Gene namesi
Name:CRADD
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793281 – 199Death domain-containing protein CRADDAdd BLAST199

Interactioni

Subunit structurei

Interacts with LRDD.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005515

Structurei

3D structure databases

ProteinModelPortaliQ5R6I4
SMRiQ5R6I4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91CARDPROSITE-ProRule annotationAdd BLAST91
Domaini116 – 188DeathPROSITE-ProRule annotationAdd BLAST73

Domaini

Contains a death domain involved in the binding of RIP protein.By similarity
The CARD domain mediates the interaction with caspase-2.By similarity

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
GeneTreeiENSGT00390000014448
HOVERGENiHBG051112
InParanoidiQ5R6I4
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P
TreeFamiTF333055

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R6I4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARDKQVLR LLRLELGAEV LVEGLVLQYL YQEGILTENH VQEINAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG
110 120 130 140 150
DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Length:199
Mass (Da):22,725
Last modified:December 21, 2004 - v1
Checksum:i47B923B3B6F68F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860505 mRNA Translation: CAH92626.1
RefSeqiNP_001126538.1, NM_001133066.1
XP_009246375.1, XM_009248100.1
XP_009246376.1, XM_009248101.1
UniGeneiPab.11875

Genome annotation databases

EnsembliENSPPYT00000005728; ENSPPYP00000005515; ENSPPYG00000004835
GeneIDi100173528
KEGGipon:100173528

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860505 mRNA Translation: CAH92626.1
RefSeqiNP_001126538.1, NM_001133066.1
XP_009246375.1, XM_009248100.1
XP_009246376.1, XM_009248101.1
UniGeneiPab.11875

3D structure databases

ProteinModelPortaliQ5R6I4
SMRiQ5R6I4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000005515

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000005728; ENSPPYP00000005515; ENSPPYG00000004835
GeneIDi100173528
KEGGipon:100173528

Organism-specific databases

CTDi8738

Phylogenomic databases

eggNOGiENOG410IJAM Eukaryota
ENOG4111SYE LUCA
GeneTreeiENSGT00390000014448
HOVERGENiHBG051112
InParanoidiQ5R6I4
KOiK02832
OMAiLGPEWEH
OrthoDBiEOG091G0M3P
TreeFamiTF333055

Family and domain databases

CDDicd08319 Death_RAIDD, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR037939 CRADD
IPR037926 CRADD_Death
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
PANTHERiPTHR15034 PTHR15034, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00531 Death, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50017 DEATH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRADD_PONAB
AccessioniPrimary (citable) accession number: Q5R6I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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