UniProtKB - Q5R603 (GPM6B_PONAB)
Protein
Neuronal membrane glycoprotein M6-b
Gene
GPM6B
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake (By similarity).By similarity
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- extracellular matrix assembly Source: UniProtKB
- negative regulation of protein localization to cell surface Source: UniProtKB
- negative regulation of serotonin uptake Source: UniProtKB
- nervous system development Source: UniProtKB-KW
- ossification Source: UniProtKB-KW
- positive regulation of bone mineralization Source: UniProtKB
- protein transport Source: UniProtKB-KW
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of focal adhesion assembly Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis, Osteogenesis, Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal membrane glycoprotein M6-bShort name: M6b |
Gene namesi | Name:GPM6B Synonyms:M6B |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Note: Colocalizes with SERT at the plasma membrane.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 31 – 51 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159023 | 1 – 265 | Neuronal membrane glycoprotein M6-bAdd BLAST | 265 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 257 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinInteractioni
Subunit structurei
Interacts with SERT.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the myelin proteolipid protein family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q5R603 |
OMAi | MMDQVFH |
OrthoDBi | 914457at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001614, Myelin_PLP IPR018237, Myelin_PLP_CS |
PANTHERi | PTHR11683, PTHR11683, 1 hit |
Pfami | View protein in Pfam PF01275, Myelin_PLP, 1 hit |
PRINTSi | PR00214, MYELINPLP |
SMARTi | View protein in SMART SM00002, PLP, 1 hit |
PROSITEi | View protein in PROSITE PS00575, MYELIN_PLP_1, 1 hit PS01004, MYELIN_PLP_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R603-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPAMETAAE ENTEQSQKRK GCFECCIKCL GGVPYASLVA TILCFSGVAL
60 70 80 90 100
FCGCGHVALA GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL
110 120 130 140 150
YVIILLAEGF YTTSAVKELH GEFKTTACGR CISGMFVFLT YVLGVAWLGV
160 170 180 190 200
FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT GVEQICVDIR QYGIIPWNAF
210 220 230 240 250
PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL IYMMATTYNY
260
AVLKFKSRED CCTKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860697 mRNA Translation: CAH92813.1 |
RefSeqi | NP_001126642.1, NM_001133170.1 |
Genome annotation databases
GeneIDi | 100173640 |
KEGGi | pon:100173640 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860697 mRNA Translation: CAH92813.1 |
RefSeqi | NP_001126642.1, NM_001133170.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 100173640 |
KEGGi | pon:100173640 |
Organism-specific databases
CTDi | 2824 |
Phylogenomic databases
InParanoidi | Q5R603 |
OMAi | MMDQVFH |
OrthoDBi | 914457at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001614, Myelin_PLP IPR018237, Myelin_PLP_CS |
PANTHERi | PTHR11683, PTHR11683, 1 hit |
Pfami | View protein in Pfam PF01275, Myelin_PLP, 1 hit |
PRINTSi | PR00214, MYELINPLP |
SMARTi | View protein in SMART SM00002, PLP, 1 hit |
PROSITEi | View protein in PROSITE PS00575, MYELIN_PLP_1, 1 hit PS01004, MYELIN_PLP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPM6B_PONAB | |
Accessioni | Q5R603Primary (citable) accession number: Q5R603 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families