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UniProtKB - Q5R5T8 (SVOP_PONAB)
Protein
Synaptic vesicle 2-related protein
Gene
SVOP
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic vesicle 2-related proteinShort name: SV2-related protein |
Gene namesi | Name:SVOP |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 87 | CytoplasmicSequence analysisAdd BLAST | 87 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 122 | VesicularSequence analysisAdd BLAST | 14 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 156 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 180 | VesicularSequence analysis | 3 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 209 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 238 | VesicularSequence analysis | 8 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 316 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 373 | VesicularSequence analysisAdd BLAST | 36 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 395 – 401 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 424 | VesicularSequence analysis | 2 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 457 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 479 – 489 | VesicularSequence analysisAdd BLAST | 11 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 511 – 548 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279454 | 1 – 548 | Synaptic vesicle 2-related proteinAdd BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 542 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0253, Eukaryota |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q5R5T8 |
OMAi | FFFAYTQ |
OrthoDBi | 1430447at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R5T8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEDLFQLRQ LPVVKFCRTG ESARSEDDTA SGEHEVQIEG VRVGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCGI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK
410 420 430 440 450
KTMALCFVIF SFCSLLLFIC VGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRGLQES SHREWGQEMV GRGMHGADVT RSNSGSQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860765 mRNA Translation: CAH92878.1 |
RefSeqi | NP_001126685.1, NM_001133213.1 |
Genome annotation databases
GeneIDi | 100173685 |
KEGGi | pon:100173685 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860765 mRNA Translation: CAH92878.1 |
RefSeqi | NP_001126685.1, NM_001133213.1 |
3D structure databases
SMRi | Q5R5T8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000005619 |
Genome annotation databases
GeneIDi | 100173685 |
KEGGi | pon:100173685 |
Organism-specific databases
CTDi | 55530 |
Phylogenomic databases
eggNOGi | KOG0253, Eukaryota |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q5R5T8 |
OMAi | FFFAYTQ |
OrthoDBi | 1430447at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SVOP_PONAB | |
Accessioni | Q5R5T8Primary (citable) accession number: Q5R5T8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families