Uncharacterized protein DKFZp469E1714

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-catenin binding Source: Ensembl
• cadherin binding Source: Ensembl
• chromatin binding Source: Ensembl
• disordered domain specific binding Source: Ensembl
• nuclear hormone receptor binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: Ensembl
• repressing transcription factor binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: UniProtKB
• transcription coactivator activity Source: UniProtKB

GO - Biological processⁱ

• adherens junction assembly Source: UniProtKB
• anterior/posterior axis specification Source: Ensembl
• astrocyte-dopaminergic neuron signaling Source: Ensembl
• bone resorption Source: Ensembl
• branching involved in blood vessel morphogenesis Source: Ensembl
• branching involved in ureteric bud morphogenesis Source: Ensembl
• canonical Wnt signaling pathway Source: UniProtKB
• canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: Ensembl
• canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: Ensembl
• canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Source: UniProtKB
• cell adhesion Source: UniProtKB
• cell-cell adhesion Source: UniProtKB
• cell fate specification Source: Ensembl
• cell-matrix adhesion Source: Ensembl
• cell maturation Source: Ensembl
• cell morphogenesis involved in differentiation Source: Ensembl
• cellular response to growth factor stimulus Source: UniProtKB
• cellular response to indole-3-methanol Source: UniProtKB
• central nervous system vasculogenesis Source: Ensembl
• chemical synaptic transmission Source: Ensembl
• chromatin-mediated maintenance of transcription Source: Ensembl
• cranial ganglion development Source: Ensembl
• cranial skeletal system development Source: Ensembl
• dorsal/ventral axis specification Source: Ensembl
• dorsal root ganglion development Source: Ensembl
• ectoderm development Source: Ensembl
• embryonic axis specification Source: Ensembl
• embryonic brain development Source: Ensembl
• embryonic digit morphogenesis Source: Ensembl
• embryonic foregut morphogenesis Source: Ensembl
• embryonic forelimb morphogenesis Source: Ensembl
• embryonic heart tube development Source: Ensembl
• embryonic hindlimb morphogenesis Source: Ensembl
• embryonic skeletal limb joint morphogenesis Source: Ensembl
• endodermal cell fate commitment Source: Ensembl
• endothelial tube morphogenesis Source: UniProtKB
• epithelial cell differentiation involved in prostate gland development Source: Ensembl
• epithelial tube branching involved in lung morphogenesis Source: Ensembl
• fungiform papilla formation Source: Ensembl
• gastrulation with mouth forming second Source: Ensembl
• genitalia morphogenesis Source: Ensembl
• glial cell fate determination Source: Ensembl
• hair follicle morphogenesis Source: Ensembl
• hair follicle placode formation Source: Ensembl
• hindbrain development Source: Ensembl
• in utero embryonic development Source: Ensembl
• layer formation in cerebral cortex Source: Ensembl
• lens morphogenesis in camera-type eye Source: Ensembl
• lung-associated mesenchyme development Source: Ensembl
• lung cell differentiation Source: Ensembl
• lung induction Source: Ensembl
• male genitalia development Source: Ensembl
• mesenchymal cell proliferation involved in lung development Source: Ensembl
• metanephros morphogenesis Source: Ensembl
• midbrain dopaminergic neuron differentiation Source: Ensembl
• negative regulation of angiogenesis Source: Ensembl
• negative regulation of apoptotic signaling pathway Source: Ensembl
• negative regulation of cell population proliferation Source: UniProtKB
• negative regulation of chondrocyte differentiation Source: Ensembl
• negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
• negative regulation of mitotic cell cycle, embryonic Source: Ensembl
• negative regulation of oligodendrocyte differentiation Source: Ensembl
• negative regulation of osteoclast differentiation Source: Ensembl
• negative regulation of oxidative stress-induced neuron death Source: Ensembl
• negative regulation of transcription, DNA-templated Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• nephron tubule formation Source: Ensembl
• neural plate development Source: Ensembl
• neuron migration Source: Ensembl
• odontogenesis of dentin-containing tooth Source: Ensembl
• oocyte development Source: Ensembl
• osteoclast differentiation Source: Ensembl
• oviduct development Source: Ensembl
• pancreas development Source: Ensembl
• positive regulation of apoptotic process Source: UniProtKB
• positive regulation of branching involved in lung morphogenesis Source: Ensembl
• positive regulation of chromatin-mediated maintenance of transcription Source: Ensembl
• positive regulation of core promoter binding Source: Ensembl
• positive regulation of determination of dorsal identity Source: Ensembl
• positive regulation of DNA-binding transcription factor activity Source: Ensembl
• positive regulation of DNA-templated transcription, initiation Source: Ensembl
• positive regulation of endothelial cell differentiation Source: Ensembl
• positive regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
• positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
• positive regulation of heparan sulfate proteoglycan biosynthetic process Source: UniProtKB
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• positive regulation of MAPK cascade Source: Ensembl
• positive regulation of mesenchymal cell proliferation Source: Ensembl
• positive regulation of neuroblast proliferation Source: Ensembl
• positive regulation of osteoblast differentiation Source: Ensembl
• positive regulation of skeletal muscle tissue development Source: Ensembl
• positive regulation of telomerase activity Source: Ensembl
• positive regulation of telomere maintenance via telomerase Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
• protein localization to cell surface Source: UniProtKB
• proximal/distal pattern formation Source: Ensembl
• regulation of calcium ion import Source: UniProtKB
• regulation of centriole-centriole cohesion Source: UniProtKB
• regulation of centromeric sister chromatid cohesion Source: UniProtKB
• regulation of euchromatin binding Source: Ensembl
• regulation of myelination Source: Ensembl
• regulation of nephron tubule epithelial cell differentiation Source: Ensembl
• regulation of protein localization to cell surface Source: UniProtKB
• regulation of secondary heart field cardioblast proliferation Source: Ensembl
• regulation of smooth muscle cell proliferation Source: UniProtKB
• regulation of T cell proliferation Source: Ensembl
• regulation of timing of anagen Source: Ensembl
• renal inner medulla development Source: Ensembl
• renal outer medulla development Source: Ensembl
• renal vesicle formation Source: Ensembl
• response to estradiol Source: UniProtKB
• smooth muscle cell differentiation Source: Ensembl
• sympathetic ganglion development Source: Ensembl
• synapse organization Source: Ensembl
• synaptic vesicle clustering Source: Ensembl
• synaptic vesicle transport Source: Ensembl
• T cell differentiation in thymus Source: Ensembl
• thymus development Source: Ensembl
• trachea formation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• alpha-catenin binding Source: Ensembl
• cadherin binding Source: Ensembl
• disordered domain specific binding Source: Ensembl
• nuclear hormone receptor binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: Ensembl
• repressing transcription factor binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG 
        60         70         80         90        100
NPEEEDVDTS QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP 
       110        120        130        140        150
ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT 
       160        170        180        190        200
RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR 
       210        220        230        240        250
TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS 
       260        270        280        290        300
VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 
       310        320        330        340        350
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC 
       360        370        380        390        400
SSNKPAIVEA GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG 
       410        420        430        440        450
LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT 
       460        470        480        490        500
VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP 
       510        520        530        540        550
PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR 
       560        570        580        590        600
TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 
       610        620        630        640        650
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG 
       660        670        680        690        700
VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI 
       710        720        730        740        750
GAQGEPLGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV 
       760        770        780 
DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ