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UniProtKB - Q5R5D8 (BODG_PONAB)
Protein
Gamma-butyrobetaine dioxygenase
Gene
BBOX1
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
By similarityCatalytic activityi
- EC:1.14.11.1
Cofactori
Protein has several cofactor binding sites:- Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
- L-ascorbateBy similarity
: carnitine biosynthesis Pathwayi
This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 38 | ZincBy similarity | 1 | |
Metal bindingi | 40 | ZincBy similarity | 1 | |
Metal bindingi | 43 | ZincBy similarity | 1 | |
Metal bindingi | 82 | ZincBy similarity | 1 | |
Metal bindingi | 202 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 204 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 347 | Iron; catalyticBy similarity | 1 |
GO - Molecular functioni
- gamma-butyrobetaine dioxygenase activity Source: UniProtKB
- iron ion binding Source: InterPro
- zinc ion binding Source: UniProtKB
GO - Biological processi
- carnitine biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Carnitine biosynthesis |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00118 |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-butyrobetaine dioxygenase (EC:1.14.11.1)Alternative name(s): Gamma-butyrobetaine hydroxylase Short name: Gamma-BBH Gamma-butyrobetaine,2-oxoglutarate dioxygenase |
Gene namesi | Name:BBOX1 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260155 | 1 – 387 | Gamma-butyrobetaine dioxygenaseAdd BLAST | 387 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 351 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the gamma-BBH/TMLD family.Curated
Phylogenomic databases
eggNOGi | KOG3888, Eukaryota |
InParanoidi | Q5R5D8 |
OrthoDBi | 868657at2759 |
Family and domain databases
Gene3Di | 3.30.2020.30, 1 hit 3.60.130.10, 1 hit |
InterProi | View protein in InterPro IPR012775, GBBH IPR010376, GBBH-like_N IPR038492, GBBH-like_N_sf IPR042098, TauD-like_sf IPR003819, TauD/TfdA-like |
Pfami | View protein in Pfam PF06155, GBBH-like_N, 1 hit PF02668, TauD, 1 hit |
TIGRFAMsi | TIGR02409, carnitine_bodg, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R5D8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACTIQKAEA LDGARLMQIL WYDEEESLYP AVWLRDNCPC SDCYLDSAKA
60 70 80 90 100
RKLLAEALDV NIGIKGLTFD RKKVYITWPD EHYSEFQADW LKKRCLSKQA
110 120 130 140 150
RAKLQRELFF PECQYWGSEL QLPTLDFEDV LRYDEHAYKW LSTLKKVGIV
160 170 180 190 200
RLTGASDKPG EVSKLGKRMG FLYLTFYGHT WQVQDKIDAN NVAYTTGKLS
210 220 230 240 250
FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK LKKNNPQAFQ
260 270 280 290 300
ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRIN FNNATRDTIF
310 320 330 340 350
DVPVERVQPF YAALKEFVDL MNSKESKFTF KMNPGDVITF DNWRLLHGRR
360 370 380
SYEAGTEISR HLEGAYADWD VVMSRLRILR QRVENGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860924 mRNA Translation: CAH93028.1 |
RefSeqi | NP_001126790.1, NM_001133318.1 |
Genome annotation databases
GeneIDi | 100173794 |
KEGGi | pon:100173794 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860924 mRNA Translation: CAH93028.1 |
RefSeqi | NP_001126790.1, NM_001133318.1 |
3D structure databases
SMRi | Q5R5D8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000003911 |
Genome annotation databases
GeneIDi | 100173794 |
KEGGi | pon:100173794 |
Organism-specific databases
CTDi | 8424 |
Phylogenomic databases
eggNOGi | KOG3888, Eukaryota |
InParanoidi | Q5R5D8 |
OrthoDBi | 868657at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00118 |
Family and domain databases
Gene3Di | 3.30.2020.30, 1 hit 3.60.130.10, 1 hit |
InterProi | View protein in InterPro IPR012775, GBBH IPR010376, GBBH-like_N IPR038492, GBBH-like_N_sf IPR042098, TauD-like_sf IPR003819, TauD/TfdA-like |
Pfami | View protein in Pfam PF06155, GBBH-like_N, 1 hit PF02668, TauD, 1 hit |
TIGRFAMsi | TIGR02409, carnitine_bodg, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BODG_PONAB | |
Accessioni | Q5R5D8Primary (citable) accession number: Q5R5D8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families