UniProtKB - Q5R581 (KLC1_PONAB)
Protein
Kinesin light chain 1
Gene
KLC1
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity
Caution
It is uncertain whether Met-1 or Met-5 is the initiator.Curated
GO - Molecular functioni
- microtubule motor activity Source: InterPro
Keywordsi
Molecular function | Motor protein |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin light chain 1Short name: KLC 1 |
Gene namesi | Name:KLC1 Synonyms:KNS2 |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Other locations
- growth cone By similarity
- Cytoplasmic vesicle By similarity
Cytoskeleton
- kinesin complex Source: InterPro
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- growth cone Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234299 | 1 – 560 | Kinesin light chain 1Add BLAST | 560 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 162 | PhosphoserineBy similarity | 1 | |
Modified residuei | 449 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 460 | PhosphoserineBy similarity | 1 | |
Modified residuei | 521 | Phosphoserine; by AMPKBy similarity | 1 | |
Modified residuei | 524 | Phosphoserine; by AMPKBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | Q5R581 |
Interactioni
Subunit structurei
Oligomeric complex composed of two heavy chains and two light chains.
Interacts with SPAG9.
Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections.
Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex.
Interacts with BORCS5.
Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000007016 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 213 – 246 | TPR 1Add BLAST | 34 | |
Repeati | 255 – 288 | TPR 2Add BLAST | 34 | |
Repeati | 297 – 330 | TPR 3Add BLAST | 34 | |
Repeati | 339 – 372 | TPR 4Add BLAST | 34 | |
Repeati | 381 – 414 | TPR 5Add BLAST | 34 | |
Repeati | 464 – 497 | TPR 6Add BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 31 – 99 | Sequence analysisAdd BLAST | 69 |
Sequence similaritiesi
Belongs to the kinesin light chain family.Curated
Keywords - Domaini
Coiled coil, Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1840 Eukaryota COG0457 LUCA |
InParanoidi | Q5R581 |
KOi | K10407 |
OrthoDBi | 511880at2759 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR002151 Kinesin_light IPR015792 Kinesin_light_repeat IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat |
Pfami | View protein in Pfam PF13176 TPR_7, 1 hit |
PRINTSi | PR00381 KINESINLIGHT |
SMARTi | View protein in SMART SM00028 TPR, 5 hits |
SUPFAMi | SSF48452 SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS01160 KINESIN_LIGHT, 4 hits PS50005 TPR, 6 hits PS50293 TPR_REGION, 2 hits |
i Sequence
Sequence statusi: Complete.
Q5R581-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL
60 70 80 90 100
ETLKCLKKDD ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE
110 120 130 140 150
SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF
160 170 180 190 200
MNQLKKYDDD ISPSEDKDTD STKEPLDDLF PNDEDDPGQG IQQQHSSAAA
210 220 230 240 250
AAQQGDYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD
260 270 280 290 300
HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL
310 320 330 340 350
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ
360 370 380 390 400
NQGKYEEVEY YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA
410 420 430 440 450
ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGTSFGEYG
460 470 480 490 500
GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA MRSRKQGLDN
510 520 530 540 550
VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE EVSMSVEWNG
560
MRKMKLGLVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860983 mRNA Translation: CAH93085.1 |
RefSeqi | NP_001126827.1, NM_001133355.1 |
Genome annotation databases
GeneIDi | 100173833 |
KEGGi | pon:100173833 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR860983 mRNA Translation: CAH93085.1 |
RefSeqi | NP_001126827.1, NM_001133355.1 |
3D structure databases
SMRi | Q5R581 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000007016 |
Proteomic databases
PRIDEi | Q5R581 |
Genome annotation databases
GeneIDi | 100173833 |
KEGGi | pon:100173833 |
Organism-specific databases
CTDi | 3831 |
Phylogenomic databases
eggNOGi | KOG1840 Eukaryota COG0457 LUCA |
InParanoidi | Q5R581 |
KOi | K10407 |
OrthoDBi | 511880at2759 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR002151 Kinesin_light IPR015792 Kinesin_light_repeat IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat |
Pfami | View protein in Pfam PF13176 TPR_7, 1 hit |
PRINTSi | PR00381 KINESINLIGHT |
SMARTi | View protein in SMART SM00028 TPR, 5 hits |
SUPFAMi | SSF48452 SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS01160 KINESIN_LIGHT, 4 hits PS50005 TPR, 6 hits PS50293 TPR_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLC1_PONAB | |
Accessioni | Q5R581Primary (citable) accession number: Q5R581 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | November 25, 2008 | |
Last modified: | November 13, 2019 | |
This is version 94 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families