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Protein

Rab-like protein 2A

Gene

RABL2A

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 2A
Gene namesi
Name:RABL2A
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807581 – 229Rab-like protein 2AAdd BLAST229

Interactioni

Subunit structurei

Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013385

Structurei

3D structure databases

ProteinModelPortaliQ5R573
SMRiQ5R573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
HOVERGENiHBG106536
InParanoidiQ5R573
KOiK07931

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R573-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHRTKPSE LDQGKCDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ
60 70 80 90 100
LSTYALTLYK HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV
110 120 130 140 150
FDVQRKVTYK NLSAWYTELR EFRPEIPCLV VANKIDADIN VTQKSFNFAK
160 170 180 190 200
KFSLPLYFVS AADGTNVVKL FNDAIRLAVS YKQNSQDFMD EILQELENFN
210 220
LEQEEEDVPD QEQSGSIETP SEEVASPHS
Length:229
Mass (Da):26,067
Last modified:December 21, 2004 - v1
Checksum:iE45CC0B8F637B87E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860991 mRNA Translation: CAH93093.1
RefSeqiNP_001127629.1, NM_001134157.1
UniGeneiPab.17791

Genome annotation databases

GeneIDi100174708
KEGGipon:100174708

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR860991 mRNA Translation: CAH93093.1
RefSeqiNP_001127629.1, NM_001134157.1
UniGeneiPab.17791

3D structure databases

ProteinModelPortaliQ5R573
SMRiQ5R573
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013385

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174708
KEGGipon:100174708

Organism-specific databases

CTDi11158

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
HOVERGENiHBG106536
InParanoidiQ5R573
KOiK07931

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBL2A_PONAB
AccessioniPrimary (citable) accession number: Q5R573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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