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UniProtKB - Q5R4L9 (SV2A_PONAB)
Protein
Synaptic vesicle glycoprotein 2A
Gene
SV2A
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: InterPro
- neurotransmitter transport Source: UniProtKB-KW
Keywordsi
Biological process | Neurotransmitter transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic vesicle glycoprotein 2A |
Gene namesi | Name:SV2A |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Other locations
- presynapse By similarity
- synaptic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.By similarity
Other locations
- cell projection Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 169 | CytoplasmicSequence analysisAdd BLAST | 169 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 191 – 205 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 233 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 262 | ExtracellularSequence analysis | 8 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 294 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 295 – 315 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 316 – 334 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 356 – 447 | CytoplasmicSequence analysisAdd BLAST | 92 | |
Transmembranei | 448 – 468 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 469 – 598 | ExtracellularSequence analysisAdd BLAST | 130 | |
Transmembranei | 599 – 619 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 620 – 626 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 627 – 647 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 648 – 651 | ExtracellularSequence analysis | 4 | |
Transmembranei | 652 – 672 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 673 – 685 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 686 – 708 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 709 – 712 | ExtracellularSequence analysis | 4 | |
Transmembranei | 713 – 731 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 732 – 742 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasmic vesicle, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239767 | 1 – 742 | Synaptic vesicle glycoprotein 2AAdd BLAST | 742 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 80 | PhosphoserineBy similarity | 1 | |
Modified residuei | 81 | PhosphoserineBy similarity | 1 | |
Modified residuei | 84 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 127 | PhosphoserineBy similarity | 1 | |
Modified residuei | 393 | PhosphoserineBy similarity | 1 | |
Modified residuei | 480 | PhosphotyrosineBy similarity | 1 | |
Glycosylationi | 498 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 573 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.By similarity
N-glycosylated.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinInteractioni
Subunit structurei
Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9601.ENSPPYP00000001066 |
Structurei
3D structure databases
AlphaFoldDBi | Q5R4L9 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | Interaction with SYT1By similarityAdd BLAST | 57 | |
Regioni | 40 – 144 | DisorderedSequence analysisAdd BLAST | 105 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 68 – 84 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
InParanoidi | Q5R4L9 |
OrthoDBi | 724235at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR022308, SV2 |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
TIGRFAMsi | TIGR01299, synapt_SV2, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5R4L9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE
60 70 80 90 100
EEDDDDDFPA PSDGYYRGEG TQDEEEGGAS SDATEGHDED DEIYEGEYQG
110 120 130 140 150
IPGAESGGKG ERMADGAPLA GVRGGLSDGE GPPGGRGEAQ RRKEREELAQ
160 170 180 190 200
QYEAILRECS HGRFQWTLYF VLGLALMADG VEVFVVGFVL PSAEKDMCLS
210 220 230 240 250
DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS VNSVFAFFSS
260 270 280 290 300
FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW
310 320 330 340 350
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA
360 370 380 390 400
LTTQPESPRF FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI
410 420 430 440 450
HQEDELIEIQ SDTGTWYQRW GVRALSLGGQ VWGNFLSCFG PEYRRITLMM
460 470 480 490 500
MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY ASRTKVFPGE RVEHVTFNFT
510 520 530 540 550
LENQIHRGGQ YLNDKFIGLR LKSVSFEDSL FEECYFEDVT SSNTFFRNCT
560 570 580 590 600
FINTVFYNTD LFEYKFVNSR LINSTFLHNK EGCPLDVTGT GEGAYMVYFV
610 620 630 640 650
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA
660 670 680 690 700
MIALLCLFGG VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG
710 720 730 740
ISIFTSFVGI TKAAPILFAS AALALGSSLA LKLPETRGQV LQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR861227 mRNA Translation: CAH93297.1 |
RefSeqi | NP_001126941.1, NM_001133469.1 |
Genome annotation databases
GeneIDi | 100173959 |
KEGGi | pon:100173959 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR861227 mRNA Translation: CAH93297.1 |
RefSeqi | NP_001126941.1, NM_001133469.1 |
3D structure databases
AlphaFoldDBi | Q5R4L9 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9601.ENSPPYP00000001066 |
Genome annotation databases
GeneIDi | 100173959 |
KEGGi | pon:100173959 |
Organism-specific databases
CTDi | 9900 |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
InParanoidi | Q5R4L9 |
OrthoDBi | 724235at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR022308, SV2 |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
TIGRFAMsi | TIGR01299, synapt_SV2, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SV2A_PONAB | |
Accessioni | Q5R4L9Primary (citable) accession number: Q5R4L9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families