Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Omega-amidase NIT2

Gene

NIT2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively.By similarity

Catalytic activityi

A monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton acceptorPROSITE-ProRule annotation1
Active sitei112Proton donorPROSITE-ProRule annotation1
Active sitei152NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-amidase NIT2 (EC:3.5.1.3)
Alternative name(s):
Nitrilase homolog 2
Gene namesi
Name:NIT2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202551 – 275Omega-amidase NIT2Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1
Modified residuei68N6-acetyllysine; alternateBy similarity1
Modified residuei68N6-succinyllysine; alternateBy similarity1
Modified residuei123N6-succinyllysineBy similarity1
Modified residuei130N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5R4L6

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5R4L6
SMRiQ5R4L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 247CN hydrolasePROSITE-ProRule annotationAdd BLAST244

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000222700
HOVERGENiHBG105126
InParanoidiQ5R4L6

Family and domain databases

Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R4L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFRLALIQ LQISSINSDN VTRACSFIRE AATQGAKIVS LPECFNSPYG
60 70 80 90 100
TKYFPEYAEK IPGESTQKLS EVAKECSIYL IGGSIPEEDA GKLYNTCAVF
110 120 130 140 150
GPDGTLLAKY RKIHLFDIDV PGKITFQESK TLSPGDSFCT FDTYCRVGLG
160 170 180 190 200
ICYDMRFAEL AQIYAQRGCQ LLVYPGAFNL TTGPAHWELL QRGRAVDNQV
210 220 230 240 250
YVATASPARD DKASYVAWGH STVVNPWGEV LAKAGTEEAI VYSDIDLKKL
260 270
AEIRQQIPVF RQKRSDLYAV EMKKP
Length:275
Mass (Da):30,483
Last modified:December 21, 2004 - v1
Checksum:i940793DB9A2F348B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861230 Transcribed RNA Translation: CAH93300.1
UniGeneiPab.1648

Similar proteinsi

Entry informationi

Entry nameiNIT2_PONAB
AccessioniPrimary (citable) accession number: Q5R4L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health