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Protein

Protein phosphatase methylesterase 1

Gene

PPME1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).By similarity

Catalytic activityi

[Phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei156By similarity1
Active sitei349By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERiponab-ppme1 PPase_methylesterase_euk

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase methylesterase 1 (EC:3.1.1.89)
Short name:
PME-1
Gene namesi
Name:PPME1
Synonyms:PME1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903921 – 386Protein phosphatase methylesterase 1Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei16Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei16Omega-N-methylarginine; alternateBy similarity1
Modified residuei42PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ5R4F9

Interactioni

Subunit structurei

Binds PPP2CA and PPP2CB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000004196

Structurei

3D structure databases

ProteinModelPortaliQ5R4F9
SMRiQ5R4F9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 263Poly-Glu8

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2564 Eukaryota
COG0596 LUCA
HOVERGENiHBG053622
InParanoidiQ5R4F9
KOiK13617

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR016812 PPase_methylesterase_euk
PANTHERiPTHR14189 PTHR14189, 1 hit
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PIRSFiPIRSF022950 PPase_methylesterase_euk, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R4F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF
60 70 80 90 100
ESMEDVEVEN ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII
110 120 130 140 150
SRVQCRIVAL DLRSHGETKV KNPEDLSAET MAKDVGNVVE AMYGDLPPPI
160 170 180 190 200
MLIGHSMGGA IAVHTASSNL VPSLLGLCMI GVVEGTAMDA LNSMQNFLRG
210 220 230 240 250
RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG ITSPEGSKSI
260 270 280 290 300
VEGIIEEEEE DEEGSESISK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG
310 320 330 340 350
WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA
360 370 380
VHEDAPDKVA EAVATFLIRH RFAEPIGGFQ CVFPGC
Length:386
Mass (Da):42,257
Last modified:January 23, 2007 - v3
Checksum:iD9203FEACA52B426
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861290 mRNA Translation: CAH93357.1
RefSeqiNP_001126977.1, NM_001133505.1

Genome annotation databases

GeneIDi100173996
KEGGipon:100173996

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR861290 mRNA Translation: CAH93357.1
RefSeqiNP_001126977.1, NM_001133505.1

3D structure databases

ProteinModelPortaliQ5R4F9
SMRiQ5R4F9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000004196

Protein family/group databases

ESTHERiponab-ppme1 PPase_methylesterase_euk

Proteomic databases

PRIDEiQ5R4F9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173996
KEGGipon:100173996

Organism-specific databases

CTDi51400

Phylogenomic databases

eggNOGiKOG2564 Eukaryota
COG0596 LUCA
HOVERGENiHBG053622
InParanoidiQ5R4F9
KOiK13617

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR016812 PPase_methylesterase_euk
PANTHERiPTHR14189 PTHR14189, 1 hit
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PIRSFiPIRSF022950 PPase_methylesterase_euk, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPME1_PONAB
AccessioniPrimary (citable) accession number: Q5R4F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 69 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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