UniProtKB - Q5R3K3 (CAHM6_HUMAN)
Protein
Calcium homeostasis modulator protein 6
Gene
CALHM6
Organism
Homo sapiens (Human)
Status
Functioni
Pore-forming subunit of a voltage-gated ion channel.By similarity
GO - Molecular functioni
- cation channel activity Source: GO_Central
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5R3K3 |
Protein family/group databases
TCDBi | 1.A.84.1.6, the calcium homeostasis modulator ca(2+) channel (calhm-c) family |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium homeostasis modulator protein 6Alternative name(s): Protein FAM26F |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188820.12 |
HGNCi | HGNC:33391, CALHM6 |
neXtProti | NX_Q5R3K3 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 39 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 441168 |
OpenTargetsi | ENSG00000188820 |
PharmGKBi | PA162387644 |
Miscellaneous databases
Pharosi | Q5R3K3, Tdark |
Polymorphism and mutation databases
BioMutai | CALHM6 |
DMDMi | 74755904 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283781 | 1 – 315 | Calcium homeostasis modulator protein 6Add BLAST | 315 |
Proteomic databases
jPOSTi | Q5R3K3 |
MassIVEi | Q5R3K3 |
PaxDbi | Q5R3K3 |
PeptideAtlasi | Q5R3K3 |
PRIDEi | Q5R3K3 |
ProteomicsDBi | 63728 [Q5R3K3-1] 63729 |
PTM databases
iPTMneti | Q5R3K3 |
PhosphoSitePlusi | Q5R3K3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188820, Expressed in spleen and 199 other tissues |
ExpressionAtlasi | Q5R3K3, baseline and differential |
Genevisiblei | Q5R3K3, HS |
Organism-specific databases
HPAi | ENSG00000188820, Group enriched (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsQ5R3K3
With | #Exp. | IntAct |
---|---|---|
CBARP - isoform 2 [Q8N350-4] | 3 | EBI-19051471,EBI-19051169 |
HSD17B13 [Q7Z5P4] | 3 | EBI-19051471,EBI-18053395 |
JAGN1 [Q8N5M9] | 3 | EBI-19051471,EBI-10266796 |
Protein-protein interaction databases
BioGRIDi | 137226, 3 interactors |
IntActi | Q5R3K3, 3 interactors |
STRINGi | 9606.ENSP00000357594 |
Miscellaneous databases
RNActi | Q5R3K3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CALHM family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSG7, Eukaryota |
GeneTreei | ENSGT01000000214456 |
HOGENOMi | CLU_141357_0_0_1 |
InParanoidi | Q5R3K3 |
OMAi | AVVFQCP |
OrthoDBi | 1039097at2759 |
PhylomeDBi | Q5R3K3 |
TreeFami | TF329085 |
Family and domain databases
InterProi | View protein in InterPro IPR029569, CALHM IPR029573, CALHM6 |
PANTHERi | PTHR32261, PTHR32261, 1 hit PTHR32261:SF4, PTHR32261:SF4, 1 hit |
Pfami | View protein in Pfam PF14798, Ca_hom_mod, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5R3K3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKFRAVLDL HVKHHSALGY GLVTLLTAGG ERIFSAVAFQ CPCSAAWNLP
60 70 80 90 100
YGLVFLLVPA LALFLLGYVL SARTWRLLTG CCSSARASCG SALRGSLVCT
110 120 130 140 150
QISAAAALAP LTWVAVALLG GAFYECAATG SAAFAQRLCL GRNRSCAAEL
160 170 180 190 200
PLVPCNQAKA SDVQDLLKDL KAQSQVLGWI LIAVVIIILL IFTSVTRCLS
210 220 230 240 250
PVSFLQLKFW KIYLEQEQQI LKSKATEHAT ELAKENIKCF FEGSHPKEYN
260 270 280 290 300
TPSMKEWQQI SSLYTFNPKG QYYSMLHKYV NRKEKTHSIR STEGDTVIPV
310
LGFVDSSGIN STPEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5R3K2 | Q5R3K2_HUMAN | Calcium homeostasis modulator prote... | CALHM6 | 158 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053085 | 80 | G → R. Corresponds to variant dbSNP:rs1057192Ensembl. | 1 | |
Natural variantiVAR_071081 | 100 | T → A2 PublicationsCorresponds to variant dbSNP:rs10784Ensembl. | 1 | |
Natural variantiVAR_053086 | 293 | E → K. Corresponds to variant dbSNP:rs11544160Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055698 | 1 – 172 | Missing in isoform 2. CuratedAdd BLAST | 172 | |
Alternative sequenceiVSP_055699 | 173 – 175 | QSQ → MFP in isoform 2. Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z84488 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48228.1 BC146842 mRNA Translation: AAI46843.1 |
CCDSi | CCDS34519.1 [Q5R3K3-1] CCDS64506.1 [Q5R3K3-2] |
RefSeqi | NP_001010919.1, NM_001010919.2 [Q5R3K3-1] NP_001263389.1, NM_001276460.1 [Q5R3K3-2] XP_005267056.1, XM_005266999.3 [Q5R3K3-1] |
Genome annotation databases
Ensembli | ENST00000368605; ENSP00000357594; ENSG00000188820 [Q5R3K3-1] ENST00000368606; ENSP00000357595; ENSG00000188820 [Q5R3K3-2] |
GeneIDi | 441168 |
KEGGi | hsa:441168 |
UCSCi | uc003pwv.5, human [Q5R3K3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z84488 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48228.1 BC146842 mRNA Translation: AAI46843.1 |
CCDSi | CCDS34519.1 [Q5R3K3-1] CCDS64506.1 [Q5R3K3-2] |
RefSeqi | NP_001010919.1, NM_001010919.2 [Q5R3K3-1] NP_001263389.1, NM_001276460.1 [Q5R3K3-2] XP_005267056.1, XM_005266999.3 [Q5R3K3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6YTV | electron microscopy | 4.39 | A/B/C/D/E/F/G/H/I/J | 1-315 | [»] | |
6YTX | electron microscopy | 6.23 | A/B/C/D/E/F/G/H/I/J/K | 1-315 | [»] | |
SMRi | Q5R3K3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 137226, 3 interactors |
IntActi | Q5R3K3, 3 interactors |
STRINGi | 9606.ENSP00000357594 |
Protein family/group databases
TCDBi | 1.A.84.1.6, the calcium homeostasis modulator ca(2+) channel (calhm-c) family |
PTM databases
iPTMneti | Q5R3K3 |
PhosphoSitePlusi | Q5R3K3 |
Polymorphism and mutation databases
BioMutai | CALHM6 |
DMDMi | 74755904 |
Proteomic databases
jPOSTi | Q5R3K3 |
MassIVEi | Q5R3K3 |
PaxDbi | Q5R3K3 |
PeptideAtlasi | Q5R3K3 |
PRIDEi | Q5R3K3 |
ProteomicsDBi | 63728 [Q5R3K3-1] 63729 |
Protocols and materials databases
Antibodypediai | 19421, 36 antibodies |
Genome annotation databases
Ensembli | ENST00000368605; ENSP00000357594; ENSG00000188820 [Q5R3K3-1] ENST00000368606; ENSP00000357595; ENSG00000188820 [Q5R3K3-2] |
GeneIDi | 441168 |
KEGGi | hsa:441168 |
UCSCi | uc003pwv.5, human [Q5R3K3-1] |
Organism-specific databases
CTDi | 441168 |
DisGeNETi | 441168 |
EuPathDBi | HostDB:ENSG00000188820.12 |
GeneCardsi | CALHM6 |
HGNCi | HGNC:33391, CALHM6 |
HPAi | ENSG00000188820, Group enriched (blood, lymphoid tissue) |
neXtProti | NX_Q5R3K3 |
OpenTargetsi | ENSG00000188820 |
PharmGKBi | PA162387644 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSG7, Eukaryota |
GeneTreei | ENSGT01000000214456 |
HOGENOMi | CLU_141357_0_0_1 |
InParanoidi | Q5R3K3 |
OMAi | AVVFQCP |
OrthoDBi | 1039097at2759 |
PhylomeDBi | Q5R3K3 |
TreeFami | TF329085 |
Enzyme and pathway databases
PathwayCommonsi | Q5R3K3 |
Miscellaneous databases
BioGRID-ORCSi | 441168, 3 hits in 838 CRISPR screens |
ChiTaRSi | FAM26F, human |
GenomeRNAii | 441168 |
Pharosi | Q5R3K3, Tdark |
PROi | PR:Q5R3K3 |
RNActi | Q5R3K3, protein |
Gene expression databases
Bgeei | ENSG00000188820, Expressed in spleen and 199 other tissues |
ExpressionAtlasi | Q5R3K3, baseline and differential |
Genevisiblei | Q5R3K3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029569, CALHM IPR029573, CALHM6 |
PANTHERi | PTHR32261, PTHR32261, 1 hit PTHR32261:SF4, PTHR32261:SF4, 1 hit |
Pfami | View protein in Pfam PF14798, Ca_hom_mod, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAHM6_HUMAN | |
Accessioni | Q5R3K3Primary (citable) accession number: Q5R3K3 Secondary accession number(s): B9EJB0, Q5R3K4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations