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UniProtKB - Q5R3F8 (PPR29_HUMAN)
Protein
Protein phosphatase 1 regulatory subunit 29
Gene
ELFN2
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
1 PublicationGO - Molecular functioni
- protein phosphatase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q5R3F8 |
SignaLinki | Q5R3F8 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 29Alternative name(s): Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2 Leucine-rich repeat and fibronectin type-III domain-containing protein 6 Leucine-rich repeat-containing protein 62 |
Gene namesi | Name:ELFN2 Synonyms:KIAA1904, LRRC62, PPP1R29 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29396, ELFN2 |
neXtProti | NX_Q5R3F8 |
VEuPathDBi | HostDB:ENSG00000166897 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- extracellular matrix Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 397 | ExtracellularSequence analysisAdd BLAST | 375 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 820 | CytoplasmicSequence analysisAdd BLAST | 402 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 114794 |
OpenTargetsi | ENSG00000166897 |
PharmGKBi | PA162385040 |
Miscellaneous databases
Pharosi | Q5R3F8, Tdark |
Genetic variation databases
BioMutai | ELFN2 |
DMDMi | 74755895 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000256138 | 23 – 820 | Protein phosphatase 1 regulatory subunit 29Add BLAST | 798 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 619 | PhosphoserineCombined sources | 1 | |
Modified residuei | 668 | PhosphoserineBy similarity | 1 | |
Modified residuei | 672 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q5R3F8 |
jPOSTi | Q5R3F8 |
MassIVEi | Q5R3F8 |
MaxQBi | Q5R3F8 |
PaxDbi | Q5R3F8 |
PeptideAtlasi | Q5R3F8 |
PRIDEi | Q5R3F8 |
ProteomicsDBi | 63725 |
PTM databases
GlyGeni | Q5R3F8, 7 sites |
iPTMneti | Q5R3F8 |
PhosphoSitePlusi | Q5R3F8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166897, Expressed in brain and 114 other tissues |
Genevisiblei | Q5R3F8, HS |
Organism-specific databases
HPAi | ENSG00000166897, Group enriched (brain, retina) |
Interactioni
Subunit structurei
Interacts with PPP1CA.
1 PublicationProtein-protein interaction databases
BioGRIDi | 125356, 18 interactors |
IntActi | Q5R3F8, 2 interactors |
STRINGi | 9606.ENSP00000385277 |
Miscellaneous databases
RNActi | Q5R3F8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 56 – 77 | LRR 1Add BLAST | 22 | |
Repeati | 80 – 101 | LRR 2Add BLAST | 22 | |
Repeati | 104 – 125 | LRR 3Add BLAST | 22 | |
Repeati | 128 – 149 | LRR 4Add BLAST | 22 | |
Repeati | 152 – 173 | LRR 5Add BLAST | 22 | |
Domaini | 185 – 247 | LRRCTAdd BLAST | 63 | |
Domaini | 292 – 379 | Fibronectin type-IIIAdd BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 250 – 294 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 508 – 527 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 589 – 612 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 654 – 677 | DisorderedSequence analysisAdd BLAST | 24 |
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVFI, Eukaryota |
GeneTreei | ENSGT00940000159737 |
HOGENOMi | CLU_018770_0_0_1 |
InParanoidi | Q5R3F8 |
OMAi | MAFECQS |
OrthoDBi | 190870at2759 |
PhylomeDBi | Q5R3F8 |
TreeFami | TF332887 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5R3F8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLGLCAAA LLCVCRPGAV RADCWLIEGD KGYVWLAICS QNQPPYETIP
60 70 80 90 100
QHINSTVHDL RLNENKLKAV LYSSLNRFGN LTDLNLTKNE ISYIEDGAFL
110 120 130 140 150
GQSSLQVLQL GYNKLSNLTE GMLRGMSRLQ FLFVQHNLIE VVTPTAFSEC
160 170 180 190 200
PSLISIDLSS NRLSRLDGAT FASLASLMVC ELAGNPFNCE CDLFGFLAWL
210 220 230 240 250
VVFNNVTKNY DRLQCESPRE FAGYPLLVPR PYHSLNAITV LQAKCRNGSL
260 270 280 290 300
PARPVSHPTP YSTDAQREPD ENSGFNPDEI LSVEPPASST TDASAGPAIK
310 320 330 340 350
LHHVTFTSAT LVVIIPHPYS KMYILVQYNN SYFSDVMTLK NKKEIVTLDK
360 370 380 390 400
LRAHTEYTFC VTSLRNSRRF NHTCLTFTTR DPVPGDLAPS TSTTTHYIMT
410 420 430 440 450
ILGCLFGMVI VLGAVYYCLR KRRMQEEKQK SVNVKKTILE MRYGADVDAG
460 470 480 490 500
SIVHAAQKLG EPPVLPVSRM ASIPSMIGEK LPTAKGLEAG LDTPKVATKG
510 520 530 540 550
NYIEVRTGAG GDGLARPEDD LPDLENGQGS AAEISTIAKE VDKVNQIINN
560 570 580 590 600
CIDALKLDSA SFLGGGSSSG DPELAFECQS LPAAAAASSA TGPGALERPS
610 620 630 640 650
FLSPPYKESS HHPLQRQLSA DAAVTRKTCS VSSSGSIKSA KVFSLDVPDH
660 670 680 690 700
PAATGLAKGD SKYIEKGSPL NSPLDRLPLV PAGSGGGSGG GGGIHHLEVK
710 720 730 740 750
PAYHCSEHRH SFPALYYEEG ADSLSQRVSF LKPLTRSKRD STYSQLSPRH
760 770 780 790 800
YYSGYSSSPE YSSESTHKIW ERFRPYKKHH REEVYMAAGH ALRKKVQFAK
810 820
DEDLHDILDY WKGVSAQQKL
Sequence cautioni
The sequence BAB67797 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 239 | T → I in BAB67797 (PubMed:11572484).Curated | 1 | |
Sequence conflicti | 605 | P → S in BAB67797 (PubMed:11572484).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB067491 mRNA Translation: BAB67797.1 Different initiation. Z94160 Genomic DNA No translation available. |
CCDSi | CCDS33642.1 |
RefSeqi | NP_443138.2, NM_052906.4 |
Genome annotation databases
Ensembli | ENST00000402918; ENSP00000385277; ENSG00000166897 |
GeneIDi | 114794 |
KEGGi | hsa:114794 |
MANE-Selecti | ENST00000402918.7; ENSP00000385277.1; NM_052906.5; NP_443138.2 |
UCSCi | uc003asq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB067491 mRNA Translation: BAB67797.1 Different initiation. Z94160 Genomic DNA No translation available. |
CCDSi | CCDS33642.1 |
RefSeqi | NP_443138.2, NM_052906.4 |
3D structure databases
SMRi | Q5R3F8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125356, 18 interactors |
IntActi | Q5R3F8, 2 interactors |
STRINGi | 9606.ENSP00000385277 |
PTM databases
GlyGeni | Q5R3F8, 7 sites |
iPTMneti | Q5R3F8 |
PhosphoSitePlusi | Q5R3F8 |
Genetic variation databases
BioMutai | ELFN2 |
DMDMi | 74755895 |
Proteomic databases
EPDi | Q5R3F8 |
jPOSTi | Q5R3F8 |
MassIVEi | Q5R3F8 |
MaxQBi | Q5R3F8 |
PaxDbi | Q5R3F8 |
PeptideAtlasi | Q5R3F8 |
PRIDEi | Q5R3F8 |
ProteomicsDBi | 63725 |
Protocols and materials databases
Antibodypediai | 274, 63 antibodies from 16 providers |
DNASUi | 114794 |
Genome annotation databases
Ensembli | ENST00000402918; ENSP00000385277; ENSG00000166897 |
GeneIDi | 114794 |
KEGGi | hsa:114794 |
MANE-Selecti | ENST00000402918.7; ENSP00000385277.1; NM_052906.5; NP_443138.2 |
UCSCi | uc003asq.4, human |
Organism-specific databases
CTDi | 114794 |
DisGeNETi | 114794 |
GeneCardsi | ELFN2 |
HGNCi | HGNC:29396, ELFN2 |
HPAi | ENSG00000166897, Group enriched (brain, retina) |
neXtProti | NX_Q5R3F8 |
OpenTargetsi | ENSG00000166897 |
PharmGKBi | PA162385040 |
VEuPathDBi | HostDB:ENSG00000166897 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVFI, Eukaryota |
GeneTreei | ENSGT00940000159737 |
HOGENOMi | CLU_018770_0_0_1 |
InParanoidi | Q5R3F8 |
OMAi | MAFECQS |
OrthoDBi | 190870at2759 |
PhylomeDBi | Q5R3F8 |
TreeFami | TF332887 |
Enzyme and pathway databases
PathwayCommonsi | Q5R3F8 |
SignaLinki | Q5R3F8 |
Miscellaneous databases
BioGRID-ORCSi | 114794, 7 hits in 1033 CRISPR screens |
ChiTaRSi | ELFN2, human |
GenomeRNAii | 114794 |
Pharosi | Q5R3F8, Tdark |
PROi | PR:Q5R3F8 |
RNActi | Q5R3F8, protein |
Gene expression databases
Bgeei | ENSG00000166897, Expressed in brain and 114 other tissues |
Genevisiblei | Q5R3F8, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PPR29_HUMAN | |
Accessioni | Q5R3F8Primary (citable) accession number: Q5R3F8 Secondary accession number(s): Q96PY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM