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Protein

Putative inactive group IIC secretory phospholipase A2

Gene

PLA2G2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inactive phospholipase.Curated

Caution

Ser-67 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.Curated
The N-terminal region is predicted based on cross-species conservation and limited EST data. Exact gene structure in this region is unclear.Curated

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi47Calcium; via carbonyl oxygenBy similarity1
Metal bindingi49Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive group IIC secretory phospholipase A2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase-like protein GIIC
Gene namesi
Name:PLA2G2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187980.6
HGNCiHGNC:9032 PLA2G2C
neXtProtiNX_Q5R387

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi391013
OpenTargetsiENSG00000187980

Chemistry databases

ChEMBLiCHEMBL2097

Polymorphism and mutation databases

DMDMi300669681

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031994619 – 149Putative inactive group IIC secretory phospholipase A2Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 142By similarity
Disulfide bondi77 ↔ 107By similarity
Disulfide bondi95 ↔ 112By similarity
Disulfide bondi97 ↔ 105Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ5R387
ProteomicsDBi63718
TopDownProteomicsiQ5R387

Expressioni

Gene expression databases

BgeeiENSG00000187980
ExpressionAtlasiQ5R387 baseline and differential

Interactioni

Chemistry databases

BindingDBiQ5R387

Structurei

3D structure databases

ProteinModelPortaliQ5R387
SMRiQ5R387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00910000144349
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiQ5R387
OMAiQSAYCFR
PhylomeDBiQ5R387
TreeFamiTF319283

Family and domain databases

Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIAILTLL LFCSPTHSSF WQFQRRVKHI TGRSAFFSYY GYGCYCGLGD
60 70 80 90 100
KGIPVDDTDR HSPSSPSPYE KLKEFSCQPV LNSYQFHIVN GAVVCGCTLG
110 120 130 140
PGASCHCRLK ACECDKQSVH CFKESLPTYE KNFKQFSSQP RCGRHKPWC
Length:149
Mass (Da):16,844
Last modified:July 13, 2010 - v3
Checksum:iEB386EF6DF86AA8B
GO

Sequence cautioni

The sequence CAI20258 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039057139Q → R. Corresponds to variant dbSNP:rs6426616Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98257 Genomic DNA Translation: CAI20258.1 Sequence problems.
PIRiA60718
UniGeneiHs.512512

Genome annotation databases

EnsembliENST00000429261; ENSP00000389335; ENSG00000187980
UCSCiuc057cyp.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPA2GC_HUMAN
AccessioniPrimary (citable) accession number: Q5R387
Secondary accession number(s): Q7M4M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 13, 2010
Last modified: June 20, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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