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Protein
Submitted name:

Carbamoyl-phosphate synthase [ammonia], mitochondrial

Gene

CPS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Carbamoyl-phosphate synthase [ammonia], mitochondrialImported
Submitted name:
Carbamoylphosphate synthetase IImported
Gene namesi
Name:CPS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000021826.14
HGNCiHGNC:2323 CPS1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000021826

PTM / Processingi

Proteomic databases

MaxQBiQ5R211
PeptideAtlasiQ5R211
PRIDEiQ5R211

Expressioni

Gene expression databases

BgeeiENSG00000021826 Expressed in 155 organ(s), highest expression level in liver
ExpressionAtlasiQ5R211 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 404Glutamine amidotransferase type-1InterPro annotationAdd BLAST186

Phylogenomic databases

eggNOGiKOG0370 Eukaryota
COG0458 LUCA
COG0505 LUCA
GeneTreeiENSGT00910000144175

Family and domain databases

CDDicd01744 GATase1_CPSase, 1 hit
Gene3Di3.40.50.880, 1 hit
3.50.30.20, 1 hit
HAMAPiMF_01209 CPSase_S_chain, 1 hit
InterProiView protein in InterPro
IPR006274 CarbamoylP_synth_ssu
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR017926 GATASE
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PRINTSiPR00098 CPSASE
SMARTiView protein in SMART
SM01097 CPSase_sm_chain, 1 hit
SUPFAMiSSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01368 CPSaseIIsmall, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5R211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRILTAFKV VRTLKTGFGF TNVTAHQKWK FSRPGIRLLS VKAQTAHIVL
60 70 80 90 100
EDGTKMKGYS FGHPSSVAGE VVFNTGLGGY PEAITDPAYK GQILTMANPI
110 120 130 140 150
IGNGGAPDTT ALDELGLSKY LESNGIKVSG LLVLDYSKDY NHWLATKSLG
160 170 180 190 200
QWLQEEKVPA IYGVDTRMLT KIIRDKGTML GKIEFEGQPV DFVDPNKQNL
210 220 230 240 250
IAEVSTKDVK VYGKGNPTKV VAVDCGIKNN VIRLLVKRGA EVHLVPWNHD
260 270 280 290 300
FTKMEYDGIL IAGGPGNPAL AEPLIQNVRK ILESDRKEPL FGISTGNLIT
310 320 330 340 350
GLAAGAKTYK MSMANRGQNQ PVLNITNKQA FITAQNHGYA LDNTLPAGWK
360 370 380 390 400
PLFVNVNDQT NEGIMHESKP FFAVQFHPEV TPGPIDTEYL FDSFFSLIKK
410 420 430 440 450
GKATTITSVL PKPALVASRV EVSKVLILGS GGLSIGQAGE FDYSGSQAVK
460 470 480 490 500
AMKEENVKTV LMNPNIASVQ TNEVGLKQAD TVYFLPITPQ FVTEVIKAEQ
510
PDGLILGMGA RQL
Length:513
Mass (Da):55,731
Last modified:January 4, 2005 - v1
Checksum:i4BF4CF04C55CA700
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P31327CPSM_HUMAN
Carbamoyl-phosphate synthase [ammon...
CPS1
1,500Annotation score:
E7EWJ3E7EWJ3_HUMAN
Carbamoyl-phosphate synthase [ammon...
CPS1
157Annotation score:
C9JTA4C9JTA4_HUMAN
Carbamoyl-phosphate synthase [ammon...
CPS1
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007970 Genomic DNA No translation available.
AC008172 Genomic DNA No translation available.
AB180933 mRNA Translation: BAD74204.1
UniGeneiHs.149252

Genome annotation databases

EnsembliENST00000619804; ENSP00000480517; ENSG00000021826
UCSCiuc061rzl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007970 Genomic DNA No translation available.
AC008172 Genomic DNA No translation available.
AB180933 mRNA Translation: BAD74204.1
UniGeneiHs.149252

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5R211
PeptideAtlasiQ5R211
PRIDEiQ5R211

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619804; ENSP00000480517; ENSG00000021826
UCSCiuc061rzl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000021826.14
HGNCiHGNC:2323 CPS1
OpenTargetsiENSG00000021826
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0370 Eukaryota
COG0458 LUCA
COG0505 LUCA
GeneTreeiENSGT00910000144175

Miscellaneous databases

ChiTaRSiCPS1 human

Gene expression databases

BgeeiENSG00000021826 Expressed in 155 organ(s), highest expression level in liver
ExpressionAtlasiQ5R211 baseline and differential

Family and domain databases

CDDicd01744 GATase1_CPSase, 1 hit
Gene3Di3.40.50.880, 1 hit
3.50.30.20, 1 hit
HAMAPiMF_01209 CPSase_S_chain, 1 hit
InterProiView protein in InterPro
IPR006274 CarbamoylP_synth_ssu
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR017926 GATASE
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PRINTSiPR00098 CPSASE
SMARTiView protein in SMART
SM01097 CPSase_sm_chain, 1 hit
SUPFAMiSSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01368 CPSaseIIsmall, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5R211_HUMAN
AccessioniPrimary (citable) accession number: Q5R211
Entry historyiIntegrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: September 12, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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