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Entry version 73 (08 May 2019)
Sequence version 1 (04 Jan 2005)
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Protein

Chromatin assembly factor 1 subunit A

Gene

CHAF1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Involved in rapid nucleosome formation during DNA replication (PubMed:17065558).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin assembly Source: UniProtKB
  • DNA repair Source: UniProtKB-KW
  • DNA replication Source: UniProtKB-KW
  • nucleosome assembly Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processCell cycle, DNA damage, DNA repair, DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin assembly factor 1 subunit A
Short name:
CAF-1 subunit A
Alternative name(s):
Chromatin assembly factor I p150 subunit
Short name:
CAF-I 150 kDa subunit
Short name:
CAF-I p150
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHAF1A
Synonyms:CAIP150
ORF Names:RCJMB04_12f19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells lacking CHAF1A show delayed S-phase progression with retarded DNA synthesis and defects in a rapid nucleosome formation of newly replicated DNA.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003738821 – 937Chromatin assembly factor 1 subunit AAdd BLAST937

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5R1T0

PRoteomics IDEntifications database

More...
PRIDEi
Q5R1T0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. Interacts with CHAF1B, PCNA and RBBP4 (PubMed:17065558).By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
690937, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000001693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5R1T0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi213 – 226PxVxL motifBy similarityAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi293 – 430Lys-richAdd BLAST138
Compositional biasi578 – 584Poly-Glu7
Compositional biasi602 – 607Poly-Asp6
Compositional biasi890 – 895Poly-Asp6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CHAF1A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4364 Eukaryota
ENOG4111K9K LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111290

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5R1T0

KEGG Orthology (KO)

More...
KOi
K10750

Database of Orthologous Groups

More...
OrthoDBi
1362011at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5R1T0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029105 CAF1-p150_C2
IPR029091 CAF1_asu_N
IPR022043 CAF1A

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15539 CAF1-p150_C2, 1 hit
PF15557 CAF1-p150_N, 1 hit
PF12253 CAF1A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5R1T0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAMECRDKA VVPPRRLVQA RLPFKRLNPV PKEKHDAEAE GKKGKCSKSG
60 70 80 90 100
LGQSKDSSTD TLHASTDNME NDCQLNSDVN FVPKLVNGKG PLDHFIQKST
110 120 130 140 150
KDNTDEIIVI IDSVDESNQR LSDDVDHVSF DSKASSAALT NGMLGKDMNK
160 170 180 190 200
LSCLNSTQNS QTDDSMQTDV PCEAIANKGE DLVDGIQSCS GLTERNNLEN
210 220 230 240 250
TKVNQSELKD VIFEGKMPVV LLEDIMAAKS PQVTSLDGSV TSENETVELS
260 270 280 290 300
HEGDSVLTNS SLSSLSVSSP EAQPVAETKR NTSPLAVSTP VRKVSQKLHK
310 320 330 340 350
SSAEKEKLRL QRDQERADKL QKLQAEREEK GRLKEEAKAA KERAKEEAKK
360 370 380 390 400
KKEEEKELKE RERREKKEKE EKEKAEKLRV KEEKRKERQE ALEAKLEEKR
410 420 430 440 450
KKEEEKRLKE EEKRINAQKA EITRFFQKPK TPQAPKILAG SCGKFAPFEI
460 470 480 490 500
KENMVLAPLC RIALYPDFLE QLDRLLRAQN SEVSFLRDLK CRKPRKTGPT
510 520 530 540 550
FVNSSTDTVN SDVVVVDNCK TDAVPERGKF GRMKLLQFCE NHRPAYWGTW
560 570 580 590 600
NKKTTMIRPR NPWSKDSKLL DYEVDSDEEW EEEEPGESLS HSEGDDEEEG
610 620 630 640 650
EDEDDDDGFF IPHGYLSEDE GVTEECDPEN QKVRQKLKAK EWDELMAKGK
660 670 680 690 700
RLHVLQPVKI GCIWESAQND SGTNADLKIL QQFTACILDS SVAEEEQQIQ
710 720 730 740 750
KCSKKRAKDQ QILGQLLPLL HGNVNGSKVI IQEFQECCRQ GLFSDVTAAT
760 770 780 790 800
DCGDTSPVSP NTSRPQTPVG EDSGVPSKAR LKRIISENSV YEKRPEYRMC
810 820 830 840 850
WYVHSEVLKS FDQEHLPVPC QWNYITQVPS SGKEDGGSVP GVAPVQSTPV
860 870 880 890 900
SVKRKSTGSM CITKFMKRPR DAEQAEAMEM DGFQADTEED EDDDDCMIVD
910 920 930
VQPCKDSTLT VTETAPESRG TTAAHQDASM VSPSNTV
Length:937
Mass (Da):105,133
Last modified:January 4, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD4A599B43B506D0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAG31858 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAG31858 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62L → S in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti97Q → R in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti148M → T in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti247V → I in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti611I → V in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti842V → I in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti856S → C in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti914T → A in CAG31858 (PubMed:15642098).Curated1
Sequence conflicti919R → S in CAG31858 (PubMed:15642098).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB195692 mRNA Translation: BAD72952.1
AJ720199 mRNA Translation: CAG31858.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001073220.2, NM_001079752.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
770217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:770217

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB195692 mRNA Translation: BAD72952.1
AJ720199 mRNA Translation: CAG31858.1 Sequence problems.
RefSeqiNP_001073220.2, NM_001079752.2

3D structure databases

SMRiQ5R1T0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi690937, 3 interactors
STRINGi9031.ENSGALP00000001693

Proteomic databases

PaxDbiQ5R1T0
PRIDEiQ5R1T0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi770217
KEGGigga:770217

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10036

Phylogenomic databases

eggNOGiKOG4364 Eukaryota
ENOG4111K9K LUCA
HOGENOMiHOG000111290
InParanoidiQ5R1T0
KOiK10750
OrthoDBi1362011at2759
PhylomeDBiQ5R1T0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5R1T0

Family and domain databases

InterProiView protein in InterPro
IPR029105 CAF1-p150_C2
IPR029091 CAF1_asu_N
IPR022043 CAF1A
PfamiView protein in Pfam
PF15539 CAF1-p150_C2, 1 hit
PF15557 CAF1-p150_N, 1 hit
PF12253 CAF1A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAF1A_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5R1T0
Secondary accession number(s): Q5ZK85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 4, 2005
Last modified: May 8, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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