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Protein

Protein transport protein SEC23

Gene

SEC23B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transportUniRule annotation, Protein transportUniRule annotation, Transport
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC23UniRule annotation
Gene namesi
Name:SEC23BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101310.14
HGNCiHGNC:10702 SEC23B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, Cytoplasmic vesicleUniRule annotation, Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101310

PTM / Processingi

Proteomic databases

MaxQBiQ5QPE2
PeptideAtlasiQ5QPE2
PRIDEiQ5QPE2

Expressioni

Gene expression databases

BgeeiENSG00000101310 Expressed in 225 organ(s), highest expression level in adrenal gland
ExpressionAtlasiQ5QPE2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5QPE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 98zf-Sec23_Sec24InterPro annotationAdd BLAST41
Domaini127 – 331Sec23_trunkInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG085066

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR037364 Sec23
IPR006896 Sec23/24_trunk_dom
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF82919 SSF82919, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q5QPE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD
60 70 80 90 100
LPPVQYEPVL CSRPTCKAVL NPLCQVDYRA KLWACNFCFQ RNQFPPAYGG
110 120 130 140 150
ISEVNQPAEL MPQFSTIEYV IQRGAQSPLI FLYVVDTCLE EDDLQALKES
160 170 180 190 200
LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI
210 220 230 240 250
QDMLGLTKPA MPMQQARPAQ PQEHPFASSR FLQPVHKIDM NLTDLLGELQ
260 270 280 290 300
RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP
310 320 330
GMVVGDELKI PIRSWHDIEK DNARFMKKAT K
Length:331
Mass (Da):37,143
Last modified:January 4, 2005 - v1
Checksum:i16AAB465D841A953
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q15437SC23B_HUMAN
Protein transport protein Sec23B
SEC23B
767Annotation score:
A0A2R8YFH5A0A2R8YFH5_HUMAN
Protein transport protein SEC23
SEC23B
749Annotation score:
Q5QPE1Q5QPE1_HUMAN
Protein transport protein SEC23
SEC23B
246Annotation score:
A0A2R8Y633A0A2R8Y633_HUMAN
Protein transport protein SEC23
SEC23B
52Annotation score:
A0A2R8YF30A0A2R8YF30_HUMAN
Protein transport protein SEC23
SEC23B
32Annotation score:
A0A2R8Y7S7A0A2R8Y7S7_HUMAN
Protein transport protein SEC23
SEC23B
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei331Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121893 Genomic DNA No translation available.
AL121900 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000450074; ENSP00000403971; ENSG00000101310
UCSCiuc061vqp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121893 Genomic DNA No translation available.
AL121900 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5QPE2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5QPE2
PeptideAtlasiQ5QPE2
PRIDEiQ5QPE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450074; ENSP00000403971; ENSG00000101310
UCSCiuc061vqp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000101310.14
HGNCiHGNC:10702 SEC23B
OpenTargetsiENSG00000101310
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916
HOGENOMiHOG000231690
HOVERGENiHBG085066

Miscellaneous databases

ChiTaRSiSEC23B human

Gene expression databases

BgeeiENSG00000101310 Expressed in 225 organ(s), highest expression level in adrenal gland
ExpressionAtlasiQ5QPE2 baseline and differential

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR037364 Sec23
IPR006896 Sec23/24_trunk_dom
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF82919 SSF82919, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5QPE2_HUMAN
AccessioniPrimary (citable) accession number: Q5QPE2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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