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UniProtKB - Q5QP56 (Q5QP56_HUMAN)
Protein
Apoptosis regulator Bcl-X
Gene
BCL2L1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- apoptotic process Source: UniProtKB-UniRule
- positive regulation of apoptotic process Source: UniProt
- regulation of cellular response to stress Source: UniProt
Keywordsi
Biological process | ApoptosisPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis regulator Bcl-XARBA annotationAlternative name(s): Bcl-2-like protein 1ARBA annotation |
Gene namesi | Name:BCL2L1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:992, BCL2L1 |
VEuPathDBi | HostDB:ENSG00000171552 |
Subcellular locationi
Nucleus
- Nucleus membrane ARBA annotation; Single-pass membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- centrosome ARBA annotation
Mitochondrion
- Mitochondrion matrix ARBA annotation
Cytoplasm and Cytosol
- cytosol ARBA annotation
Other locations
- synaptic vesicle membrane ARBA annotation
- Membrane ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicleARBA annotation, CytoskeletonARBA annotation, Membrane, MitochondrionARBA annotation, NucleusARBA annotation, SynapseARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | Q5QP56 |
PeptideAtlasi | Q5QP56 |
PRIDEi | Q5QP56 |
ProteomicsDBi | 63636 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171552, Expressed in upper lobe of left lung and 238 other tissues |
ExpressionAtlasi | Q5QP56, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 24 | BH4_2InterPro annotationAdd BLAST | 20 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 71 | DisorderedSequence analysisAdd BLAST | 44 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 24 | BH4PROSITE-ProRule annotationAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the Bcl-2 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT01020000230347 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR020717, Bcl2_BH1_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF12, PTHR11256:SF12, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q5QP56-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP W
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ07817 | B2CL1_HUMAN | Bcl-2-like protein 1 | BCL2L1 BCL2L, BCLX | 233 | Annotation score: | ||
Q5TE64 | Q5TE64_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 307 | Annotation score: | ||
Q9H1R6 | Q9H1R6_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 188 | Annotation score: | ||
A0A7I2V597 | A0A7I2V597_HUMAN | Apoptosis regulator Bcl-X | BCL2L1 | 200 | Annotation score: | ||
Q5QP59 | Q5QP59_HUMAN | Bcl-2-like protein 1 | BCL2L1 | 48 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 181 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117381 Genomic DNA No translation available. AL160175 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000439267; ENSP00000389688; ENSG00000171552 |
UCSCi | uc061wcr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117381 Genomic DNA No translation available. AL160175 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5QP56 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5QP56 |
PeptideAtlasi | Q5QP56 |
PRIDEi | Q5QP56 |
ProteomicsDBi | 63636 |
Protocols and materials databases
Antibodypediai | 3430, 2000 antibodies from 52 providers |
Genome annotation databases
Ensembli | ENST00000439267; ENSP00000389688; ENSG00000171552 |
UCSCi | uc061wcr.1, human |
Organism-specific databases
HGNCi | HGNC:992, BCL2L1 |
OpenTargetsi | ENSG00000171552 |
VEuPathDBi | HostDB:ENSG00000171552 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01020000230347 |
Miscellaneous databases
ChiTaRSi | BCL2L1, human |
Gene expression databases
Bgeei | ENSG00000171552, Expressed in upper lobe of left lung and 238 other tissues |
ExpressionAtlasi | Q5QP56, baseline and differential |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR020717, Bcl2_BH1_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF12, PTHR11256:SF12, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5QP56_HUMAN | |
Accessioni | Q5QP56Primary (citable) accession number: Q5QP56 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 4, 2005 |
Last sequence update: | January 4, 2005 | |
Last modified: | January 19, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |