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Protein

Hepatitis A virus cellular receptor 1 homolog

Gene

Havcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity).By similarity1 Publication

Miscellaneous

Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.

GO - Molecular functioni

  • phosphatidylserine binding Source: MGI

GO - Biological processi

  • positive regulation of mast cell activation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1 homolog
Short name:
HAVcr-1
Alternative name(s):
Kidney injury molecule 1
Short name:
KIM-1
T cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T cell membrane protein 1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM-1
Gene namesi
Name:Havcr1
Synonyms:Kim1, Tim1, Timd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2159680 Havcr1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 237ExtracellularSequence analysisAdd BLAST216
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 305CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001498222 – 305Hepatitis A virus cellular receptor 1 homologAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 108PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi49 ↔ 60Combined sources1 Publication
Disulfide bondi55 ↔ 107Combined sources1 Publication
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QNS5
PRIDEiQ5QNS5

PTM databases

iPTMnetiQ5QNS5
PhosphoSitePlusiQ5QNS5

Expressioni

Tissue specificityi

Expressed by stimulated T-cells. Expressed during primary antigen stimulation.1 Publication

Gene expression databases

CleanExiMM_HAVCR1

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Timd4Q6U7R44EBI-20217708,EBI-16764486

Protein-protein interaction databases

IntActiQ5QNS5, 1 interactor
STRINGi10090.ENSMUSP00000043827

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Beta strandi33 – 35Combined sources3
Beta strandi48 – 53Combined sources6
Beta strandi57 – 59Combined sources3
Beta strandi63 – 67Combined sources5
Beta strandi69 – 77Combined sources9
Helixi86 – 88Combined sources3
Beta strandi93 – 97Combined sources5
Helixi100 – 102Combined sources3
Beta strandi104 – 110Combined sources7
Beta strandi119 – 128Combined sources10

3D structure databases

ProteinModelPortaliQ5QNS5
SMRiQ5QNS5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5QNS5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 122Ig-like V-typeAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 222Thr-richAdd BLAST83

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYS0 Eukaryota
ENOG4111VB0 LUCA
HOVERGENiHBG073424
InParanoidiQ5QNS5
KOiK20413
PhylomeDBiQ5QNS5
TreeFamiTF336163

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5QNS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQIQVFISG LILLLPGAVD SYVEVKGVVG HPVTLPCTYS TYRGITTTCW
60 70 80 90 100
GRGQCPSSAC QNTLIWTNGH RVTYQKSSRY NLKGHISEGD VSLTIENSVE
110 120 130 140 150
SDSGLYCCRV EIPGWFNDQK VTFSLQVKPE IPTRPPTRPT TTRPTATGRP
160 170 180 190 200
TTISTRSTHV PTSIRVSTST PPTSTHTWTH KPEPTTFCPH ETTAEVTGIP
210 220 230 240 250
SHTPTDWNGT VTSSGDTWSN HTEAIPPGKP QKNPTKGFYV GICIAALLLL
260 270 280 290 300
LLVSTVAITR YILMKRKSAS LSVVAFRVSK IEALQNAAVV HSRAEDNIYI

VEDRP
Length:305
Mass (Da):33,361
Last modified:August 30, 2005 - v2
Checksum:iF995C93A9125E4FE
GO
Isoform 2 (identifier: Q5QNS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-205: Missing.

Show »
Length:282
Mass (Da):30,925
Checksum:iA05455445ED0A5C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152T → A in AAH53400 (PubMed:15489334).Curated1

Polymorphismi

Highly polymorphic. Depending on the alleles, expression is associated with an increase and early (BALB/c allele) or decrease (HBA allele) of T-helper type 2 cytokine expression. Associated with asthma susceptibility.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti18A → T in strain: HBA. 1
Natural varianti137T → R in strain: HBA. 1
Natural varianti164I → T in strain: HBA. 1
Natural varianti190 – 204Missing in strain: HBA. Add BLAST15

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015224183 – 205Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399829 mRNA Translation: AAL35774.1
AF399830 mRNA Translation: AAL35775.1
AL669892 Genomic DNA No translation available.
BC053400 mRNA Translation: AAH53400.1
CCDSiCCDS24583.1 [Q5QNS5-1]
CCDS48778.1 [Q5QNS5-2]
RefSeqiNP_001160103.1, NM_001166631.1
NP_001160104.1, NM_001166632.1
NP_599009.2, NM_134248.2
UniGeneiMm.17771

Genome annotation databases

GeneIDi171283
KEGGimmu:171283

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHAVR1_MOUSE
AccessioniPrimary (citable) accession number: Q5QNS5
Secondary accession number(s): Q7TPU2, Q8VIM1, Q8VIM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: July 18, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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