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Protein

Oxysterol-binding protein 2

Gene

Osbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds 7-ketocholesterol.By similarity

GO - Molecular functioni

  • cholesterol binding Source: MGI
  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

GO - Biological processi

  • spermatid development Source: MGI

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein 2
Gene namesi
Name:Osbp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921559 Osbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002234811 – 908Oxysterol-binding protein 2Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5QNQ6
PaxDbiQ5QNQ6
PeptideAtlasiQ5QNQ6
PRIDEiQ5QNQ6

PTM databases

iPTMnetiQ5QNQ6
PhosphoSitePlusiQ5QNQ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000020435 Expressed in 190 organ(s), highest expression level in testis
CleanExiMM_OSBP2
ExpressionAtlasiQ5QNQ6 baseline and differential
GenevisibleiQ5QNQ6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068652

Structurei

3D structure databases

ProteinModelPortaliQ5QNQ6
SMRiQ5QNQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 271PHPROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
HOVERGENiHBG053374
InParanoidiQ5QNQ6
KOiK20462
OMAiEINHTCR
OrthoDBiEOG091G04HK
PhylomeDBiQ5QNQ6
TreeFamiTF320922

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5QNQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKAAALSRG GGCAGRSRGL SSLFTVVPCL SCHTAAPGMN SSAFGSGPAS
60 70 80 90 100
KPQLQPVQAP ERELLSKQVC QPISEPASRS EPGSQTTSVP RPSGVGQESE
110 120 130 140 150
LQGLWPGSEN GTRSVSIIKA SPELAMPSPL QSTVGSLPVT KPESKLVPKT
160 170 180 190 200
QSFLRQGQAK ISVGTPVSGI GVQMVSPPLD SYKGWLLKWT NYLKGYQRRW
210 220 230 240 250
FVLGNGLLSY YRNQGEMAHT CRATINLAST HFETEDSCGI LLCNGARTYH
260 270 280 290 300
LKASSEVDRQ HWITALELAK AKAIRVMKTQ SDDSGDDDEE PAAPADNSEL
310 320 330 340 350
HHTLKTLSLK LNDLSTCNDL IAKHGAALQR SLNELDSLKI PSECGEKLKV
360 370 380 390 400
VNERATLFRI TSNAMINACR DFLELAETHS RKWQRALNYE QEQRVHLEET
410 420 430 440 450
IEQLAKQHNS LERAFCNTPG GPASSSKSFS EGSFLTSKGE NSEEDEDTEY
460 470 480 490 500
FDAMEDSTSF ITVVTEAKED RKPESGPGTT TVDWTSADNV LDGASFMPKN
510 520 530 540 550
SCKVKRRVRI PDKPNYSLNL WSIMKNCIGR ELSRIPMPVN FNEPLSMLQR
560 570 580 590 600
LTEDLEYHHL LDKAVNCTSS VEQMCLVAAF SVSSYSTTVH RIAKPFNPML
610 620 630 640 650
GETFELDRME DMGLRSLCEQ VSHHPPSAAH HVFSKHGWSL WQEITIASKF
660 670 680 690 700
RGKYISIMPL GAIHLEFQAS GNHYVWRKST STVHNIIVGK LWIDQSGDIE
710 720 730 740 750
IVNHKTKDRC QLKFVPYSYF SKEAARKVTG VVSDSQGKAH YVLSGSWDDQ
760 770 780 790 800
MECSKIVHSS PSSDGRQKTV YQTLPAKLLW RKYPLPENAE NMYYFSELAL
810 820 830 840 850
TLNEQEDGVA PTDSRLRPDQ RLMERGRWDE ANTEKQRLEE KQRLSRRRRL
860 870 880 890 900
ESCTAGCGGE EEKESDGYVP LWFEKRLDPL TGEMACMYKG GYWEAKEKKD

WHMCPNIF
Length:908
Mass (Da):101,353
Last modified:January 4, 2005 - v1
Checksum:i7CF33E2F411906D5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QNQ4Q5QNQ4_MOUSE
Oxysterol-binding protein
Osbp2
497Annotation score:
Q8K0C7Q8K0C7_MOUSE
Oxysterol-binding protein
Osbp2
455Annotation score:
Q5F209Q5F209_MOUSE
Oxysterol-binding protein 2
Osbp2
155Annotation score:
Q5F210Q5F210_MOUSE
Oxysterol-binding protein 2
Osbp2
28Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691413, AL731853 Genomic DNA Translation: CAI25066.1
AL731853, AL691413 Genomic DNA Translation: CAI51858.1
AK007088 mRNA Translation: BAC25163.1
CCDSiCCDS24367.1
RefSeqiNP_690031.2, NM_152818.2
UniGeneiMm.61022

Genome annotation databases

EnsembliENSMUST00000070552; ENSMUSP00000068652; ENSMUSG00000020435
GeneIDi74309
KEGGimmu:74309
UCSCiuc007hto.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691413, AL731853 Genomic DNA Translation: CAI25066.1
AL731853, AL691413 Genomic DNA Translation: CAI51858.1
AK007088 mRNA Translation: BAC25163.1
CCDSiCCDS24367.1
RefSeqiNP_690031.2, NM_152818.2
UniGeneiMm.61022

3D structure databases

ProteinModelPortaliQ5QNQ6
SMRiQ5QNQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068652

PTM databases

iPTMnetiQ5QNQ6
PhosphoSitePlusiQ5QNQ6

Proteomic databases

MaxQBiQ5QNQ6
PaxDbiQ5QNQ6
PeptideAtlasiQ5QNQ6
PRIDEiQ5QNQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070552; ENSMUSP00000068652; ENSMUSG00000020435
GeneIDi74309
KEGGimmu:74309
UCSCiuc007hto.2 mouse

Organism-specific databases

CTDi23762
MGIiMGI:1921559 Osbp2

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
HOVERGENiHBG053374
InParanoidiQ5QNQ6
KOiK20462
OMAiEINHTCR
OrthoDBiEOG091G04HK
PhylomeDBiQ5QNQ6
TreeFamiTF320922

Miscellaneous databases

ChiTaRSiOsbpl5 mouse
PROiPR:Q5QNQ6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020435 Expressed in 190 organ(s), highest expression level in testis
CleanExiMM_OSBP2
ExpressionAtlasiQ5QNQ6 baseline and differential
GenevisibleiQ5QNQ6 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBP2_MOUSE
AccessioniPrimary (citable) accession number: Q5QNQ6
Secondary accession number(s): Q8CF21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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