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Entry version 80 (12 Aug 2020)
Sequence version 2 (07 Jul 2009)
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Protein

Probable RNA-dependent RNA polymerase 4

Gene

RDR4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase
Biological processRNA-mediated gene silencing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable RNA-dependent RNA polymerase 4 (EC:2.7.7.48)
Short name:
OsRDR4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RDR4
Ordered Locus Names:Os01g0198000, LOC_Os01g10140
ORF Names:B1046G12.14, P0419B01.26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1
  • UP000000763 Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003784481 – 1183Probable RNA-dependent RNA polymerase 4Add BLAST1183

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5QMN4

PRoteomics IDEntifications database

More...
PRIDEi
Q5QMN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in shoot apical meristem (SAM) and panicles.1 Publication

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5QMN4, OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS01T0198000-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5QMN4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RdRP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0988, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008367_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5QMN4

KEGG Orthology (KO)

More...
KOi
K11699

Database of Orthologous Groups

More...
OrthoDBi
104603at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007855, RNA-dep_RNA_pol_euk-typ

The PANTHER Classification System

More...
PANTHERi
PTHR23079, PTHR23079, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05183, RdRP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5QMN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPHGGGNQM REPALPAAVG AELERLEARL GQLACAEARR QLAELGEPAA
60 70 80 90 100
ARVLRAIGEA RQVRTLSGFI RHMANQERMK RNARGIPTAH SAACISGPCR
110 120 130 140 150
EEESISTPLY YNEVQMDAQT PNDMVEVGSP NQQMPLRLHD NGGSVGHIAR
160 170 180 190 200
VVPDLANPAV GSPYGRISSV LLQNQNCVEG YTPSRGMVSP ASNQVGSPGH
210 220 230 240 250
RMPSGLQRHM EIDSPIQPIV STPERVSTPS PVRDLSRCVE NMAGPSGSPP
260 270 280 290 300
CPIWVMPQIP PAICPDTTNV LREVVSPQML ALGELEFRKI FMIFAYLSWN
310 320 330 340 350
KKGVKPPLST PKSSKIEDVL SVDSIRSLKS MSMAQFESRI WSTFGHDNIS
360 370 380 390 400
SSDRAKNLDS GPGMSKVYHC NVEIRGGTVV KIFKGPYIEN RRTHLQKVLG
410 420 430 440 450
DDNVLVVKFM EISSDTETDL STYLEHYHKV AEEGIVLGLR CYRFFLYKDG
460 470 480 490 500
GKENKMKEEN REEENKKCTS SVRCYFVRTE SGWNMDEPYI LSGRTIGQAR
510 520 530 540 550
DLFMHIRTVL TLAKYMLRFA LIVSKTITLD VDLSEVLVKL IDDEPCLDEH
560 570 580 590 600
GKEVFRDGER LIHTDGTGLI SEDLAQKCTY SNSKGKLLEP QDIVDCAASK
610 620 630 640 650
LMGSNNTTEY PLLIQLRLFY NGSAVKGTVL VDKRLPPRTI HIRPSMLKIK
660 670 680 690 700
TYPELSGVQS VNSLDIVSAR NAKKSLSGVQ SVNSFEIVST SNRSGRTFTS
710 720 730 740 750
NNLIALLHYG GVPEEFFMEL LQTAIEEADN ARFDYAGALN IAFNYADMED
760 770 780 790 800
SMPARMILSG IPLEESYLQS RLDFLSLLER KGIKNGKIPI DDCYYLMGTA
810 820 830 840 850
DPTGKLGPNE VCVILDYGQV SGDVLVYKYP GLHPGDIHVL KATYSSDIEK
860 870 880 890 900
VVGNSKHAIL FPTTGQRSLA DEMANSDFDG DIYWVSLNPK LLEHFKPSKP
910 920 930 940 950
WVPAITPNGT KQKGPEDFNE SELERVLFHE FLKTRFAPSY ARATAATNWL
960 970 980 990 1000
VYMDRLLTVS LDESEKKLIE KKMLKLVDLY YLALDAPKMG NKVNIPRDLM
1010 1020 1030 1040 1050
VKQYPHFMDR SPSYHSSSIL GKIYDKAGDP KPLRSDNVQP TSISSLPCFA
1060 1070 1080 1090 1100
ERDVPPAIKQ LWQHRYNEYL ADSSLLYAEE ADEEEKKIKF QELYEKYKHL
1110 1120 1130 1140 1150
LYGASEFEET PRDLDDVFSE ACAIYQIAYE KARSANNVAR CGFAWKVAGR
1160 1170 1180
ALCHFYTVKN EGNAVVCSLQ LLRNFRFTKK YRK
Length:1,183
Mass (Da):132,399
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i291AAA377BC1D134
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0P0UZ91A0A0P0UZ91_ORYSJ
RNA-dependent RNA polymerase
Os01g0198000, OSNPB_010198000
593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD73222 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD73329 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF04218 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAG89036 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP003200 Genomic DNA Translation: BAD73222.1 Sequence problems.
AP003244 Genomic DNA Translation: BAD73329.1 Sequence problems.
AP008207 Genomic DNA Translation: BAF04218.1 Sequence problems.
AP014957 Genomic DNA No translation available.
AK064209 mRNA Translation: BAG89036.1 Different initiation.
AK119908 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_015624482.1, XM_015768996.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4327336

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4327336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003200 Genomic DNA Translation: BAD73222.1 Sequence problems.
AP003244 Genomic DNA Translation: BAD73329.1 Sequence problems.
AP008207 Genomic DNA Translation: BAF04218.1 Sequence problems.
AP014957 Genomic DNA No translation available.
AK064209 mRNA Translation: BAG89036.1 Different initiation.
AK119908 mRNA No translation available.
RefSeqiXP_015624482.1, XM_015768996.1

3D structure databases

SMRiQ5QMN4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS01T0198000-01

Proteomic databases

PaxDbiQ5QMN4
PRIDEiQ5QMN4

Genome annotation databases

GeneIDi4327336
KEGGiosa:4327336

Phylogenomic databases

eggNOGiKOG0988, Eukaryota
HOGENOMiCLU_008367_1_1_1
InParanoidiQ5QMN4
KOiK11699
OrthoDBi104603at2759

Gene expression databases

GenevisibleiQ5QMN4, OS

Family and domain databases

InterProiView protein in InterPro
IPR007855, RNA-dep_RNA_pol_euk-typ
PANTHERiPTHR23079, PTHR23079, 2 hits
PfamiView protein in Pfam
PF05183, RdRP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDR4_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5QMN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 7, 2009
Last modified: August 12, 2020
This is version 80 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families
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