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Protein

Deoxynucleotidyltransferase terminal-interacting protein 2

Gene

DNTTIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.2 Publications

GO - Molecular functioni

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 2
Alternative name(s):
Estrogen receptor-binding protein
LPTS-interacting protein 2
Short name:
LPTS-RP2
Terminal deoxynucleotidyltransferase-interacting factor 2
Short name:
TdIF2
Short name:
TdT-interacting factor 2
Gene namesi
Name:DNTTIP2
Synonyms:ERBP, TDIF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000067334.13
HGNCiHGNC:24013 DNTTIP2
MIMi611199 gene
neXtProtiNX_Q5QJE6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067334
PharmGKBiPA142671963

Polymorphism and mutation databases

BioMutaiDNTTIP2
DMDMi166987398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185051 – 756Deoxynucleotidyltransferase terminal-interacting protein 2Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei129PhosphothreonineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Cross-linki217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei232PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Cross-linki257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki316Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei324PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei381PhosphoserineCombined sources1
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei434PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei569PhosphoserineCombined sources1
Cross-linki584Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei610PhosphothreonineCombined sources1
Cross-linki626Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki686Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5QJE6
MaxQBiQ5QJE6
PaxDbiQ5QJE6
PeptideAtlasiQ5QJE6
PRIDEiQ5QJE6
ProteomicsDBi63620

PTM databases

iPTMnetiQ5QJE6
PhosphoSitePlusiQ5QJE6

Expressioni

Tissue specificityi

Widely expressed with higher levels in testis.2 Publications

Gene expression databases

BgeeiENSG00000067334 Expressed in 227 organ(s), highest expression level in myocardium
CleanExiHS_DNTTIP2
ExpressionAtlasiQ5QJE6 baseline and differential
GenevisibleiQ5QJE6 HS

Organism-specific databases

HPAiHPA044502
HPA053707

Interactioni

Subunit structurei

Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA.2 Publications

Protein-protein interaction databases

BioGridi119052, 29 interactors
CORUMiQ5QJE6
IntActiQ5QJE6, 14 interactors
MINTiQ5QJE6
STRINGi9606.ENSP00000411010

Structurei

3D structure databases

ProteinModelPortaliQ5QJE6
SMRiQ5QJE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 605TdBR region; mediates interaction with DNTTAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili505 – 542Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3100 Eukaryota
ENOG410Z9Q4 LUCA
GeneTreeiENSGT00510000048142
HOVERGENiHBG106308
InParanoidiQ5QJE6
OMAiSENMSCD
OrthoDBiEOG091G0N2Q
PhylomeDBiQ5QJE6
TreeFamiTF105964

Family and domain databases

InterProiView protein in InterPro
IPR039883 Fcf2/DNTTIP2
IPR014810 Fcf2_C
PANTHERiPTHR21686 PTHR21686, 1 hit
PfamiView protein in Pfam
PF08698 Fcf2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5QJE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVTRSARAK ASIQAASAES SGQKSFAANG IQAHPESSTG SDARTTAESQ
60 70 80 90 100
TTGKQSLIPR TPKARKRKSR TTGSLPKGTE PSTDGETSEA ESNYSVSEHH
110 120 130 140 150
DTILRVTRRR QILIACSPVS SVRKKPKVTP TKESYTEEIV SEAESHVSGI
160 170 180 190 200
SRIVLPTEKT TGARRSKAKS LTDPSQESHT EAISDAETSS SDISFSGIAT
210 220 230 240 250
RRTRSMQRKL KAQTEKKDSK IVPGNEKQIV GTPVNSEDSD TRQTSHLQAR
260 270 280 290 300
SLSEINKPNF YNNDFDDDFS HRSSENILTV HEQANVESLK ETKQNCKDLD
310 320 330 340 350
EDANGITDEG KEINEKSSQL KNLSELQDTS LQQLVSQRHS TPQNKNAVSV
360 370 380 390 400
HSNLNSEAVM KSLTQTFATV EVGRWNNNKK SPIKASDLTK FGDCGGSDDE
410 420 430 440 450
EESTVISVSE DMNSEGNVDF ECDTKLYTSA PNTSQGKDNS VLLVLSSDES
460 470 480 490 500
QQSENSENEE DTLCFVENSG QRESLSGDTG SLSCDNALFV IDTTPGMSAD
510 520 530 540 550
KNFYLEEEDK ASEVAIEEEK EEEEDEKSEE DSSDHDENED EFSDEEDFLN
560 570 580 590 600
STKAKLLKLT SSSIDPGLSI KQLGGLYINF NADKLQSNKR TLTQIKEKKK
610 620 630 640 650
NELLQKAVIT PDFEKNHCVP PYSESKYQLQ KKRRKERQKT AGDGWFGMKA
660 670 680 690 700
PEMTNELKND LKALKMRASM DPKRFYKKND RDGFPKYFQI GTIVDNPADF
710 720 730 740 750
YHSRIPKKQR KRTIVEELLA DSEFRRYNRR KYSEIMAEKA ANAAGKKFRK

KKKFRN
Length:756
Mass (Da):84,469
Last modified:February 5, 2008 - v2
Checksum:i5C58EFABA2B42E4B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KP30J3KP30_HUMAN
Deoxynucleotidyltransferase termina...
DNTTIP2
601Annotation score:
E9PRB3E9PRB3_HUMAN
Deoxynucleotidyltransferase termina...
DNTTIP2
161Annotation score:

Sequence cautioni

The sequence AAA50601 differs from that shown. Reason: Frameshift at positions 717 and 726.Curated
The sequence AAH47688 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47A → D in AAQ95169 (PubMed:15047147).Curated1
Sequence conflicti47A → D in AAA50601 (Ref. 3) Curated1
Sequence conflicti67R → S in AAQ95169 (PubMed:15047147).Curated1
Sequence conflicti67R → S in AAA50601 (Ref. 3) Curated1
Sequence conflicti648M → I in BAD96442 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038748309E → D4 PublicationsCorresponds to variant dbSNP:rs3747965Ensembl.1
Natural variantiVAR_038749341T → A. Corresponds to variant dbSNP:rs3179879Ensembl.1
Natural variantiVAR_038750430A → V. Corresponds to variant dbSNP:rs35650636Ensembl.1
Natural variantiVAR_061710477G → E. Corresponds to variant dbSNP:rs41292661Ensembl.1
Natural variantiVAR_038751676Y → F. Corresponds to variant dbSNP:rs12748154Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046574 mRNA Translation: BAD08331.1
AY394925 mRNA Translation: AAQ95169.1
U15552 mRNA Translation: AAA50601.1 Frameshift.
AY336729 mRNA Translation: AAR02407.1
AK292379 mRNA Translation: BAF85068.1
AK222722 mRNA Translation: BAD96442.1
AL049796 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73064.1
BC047688 mRNA Translation: AAH47688.1 Sequence problems.
BC130622 mRNA Translation: AAI30623.1
CCDSiCCDS44174.1
PIRiG01522
RefSeqiNP_055412.2, NM_014597.4
UniGeneiHs.601998
Hs.85769

Genome annotation databases

EnsembliENST00000436063; ENSP00000411010; ENSG00000067334
GeneIDi30836
KEGGihsa:30836
UCSCiuc001dqf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046574 mRNA Translation: BAD08331.1
AY394925 mRNA Translation: AAQ95169.1
U15552 mRNA Translation: AAA50601.1 Frameshift.
AY336729 mRNA Translation: AAR02407.1
AK292379 mRNA Translation: BAF85068.1
AK222722 mRNA Translation: BAD96442.1
AL049796 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73064.1
BC047688 mRNA Translation: AAH47688.1 Sequence problems.
BC130622 mRNA Translation: AAI30623.1
CCDSiCCDS44174.1
PIRiG01522
RefSeqiNP_055412.2, NM_014597.4
UniGeneiHs.601998
Hs.85769

3D structure databases

ProteinModelPortaliQ5QJE6
SMRiQ5QJE6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119052, 29 interactors
CORUMiQ5QJE6
IntActiQ5QJE6, 14 interactors
MINTiQ5QJE6
STRINGi9606.ENSP00000411010

PTM databases

iPTMnetiQ5QJE6
PhosphoSitePlusiQ5QJE6

Polymorphism and mutation databases

BioMutaiDNTTIP2
DMDMi166987398

Proteomic databases

EPDiQ5QJE6
MaxQBiQ5QJE6
PaxDbiQ5QJE6
PeptideAtlasiQ5QJE6
PRIDEiQ5QJE6
ProteomicsDBi63620

Protocols and materials databases

DNASUi30836
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436063; ENSP00000411010; ENSG00000067334
GeneIDi30836
KEGGihsa:30836
UCSCiuc001dqf.4 human

Organism-specific databases

CTDi30836
EuPathDBiHostDB:ENSG00000067334.13
GeneCardsiDNTTIP2
H-InvDBiHIX0023574
HGNCiHGNC:24013 DNTTIP2
HPAiHPA044502
HPA053707
MIMi611199 gene
neXtProtiNX_Q5QJE6
OpenTargetsiENSG00000067334
PharmGKBiPA142671963
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3100 Eukaryota
ENOG410Z9Q4 LUCA
GeneTreeiENSGT00510000048142
HOVERGENiHBG106308
InParanoidiQ5QJE6
OMAiSENMSCD
OrthoDBiEOG091G0N2Q
PhylomeDBiQ5QJE6
TreeFamiTF105964

Miscellaneous databases

ChiTaRSiDNTTIP2 human
GeneWikiiDNTTIP2
GenomeRNAii30836
PROiPR:Q5QJE6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067334 Expressed in 227 organ(s), highest expression level in myocardium
CleanExiHS_DNTTIP2
ExpressionAtlasiQ5QJE6 baseline and differential
GenevisibleiQ5QJE6 HS

Family and domain databases

InterProiView protein in InterPro
IPR039883 Fcf2/DNTTIP2
IPR014810 Fcf2_C
PANTHERiPTHR21686 PTHR21686, 1 hit
PfamiView protein in Pfam
PF08698 Fcf2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTDIF2_HUMAN
AccessioniPrimary (citable) accession number: Q5QJE6
Secondary accession number(s): Q12987
, Q53H59, Q5TFJ4, Q6TLI0, Q76MJ8, Q86WX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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