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Entry version 124 (26 Feb 2020)
Sequence version 2 (05 Feb 2008)
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Protein

Deoxynucleotidyltransferase terminal-interacting protein 2

Gene

DNTTIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 2
Alternative name(s):
Estrogen receptor-binding protein
LPTS-interacting protein 2
Short name:
LPTS-RP2
Terminal deoxynucleotidyltransferase-interacting factor 2
Short name:
TdIF2
Short name:
TdT-interacting factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNTTIP2
Synonyms:ERBP, TDIF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24013 DNTTIP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611199 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5QJE6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000067334

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671963

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5QJE6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNTTIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166987398

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003185051 – 756Deoxynucleotidyltransferase terminal-interacting protein 2Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei129PhosphothreonineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei232PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Cross-linki257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki316Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei324PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei381PhosphoserineCombined sources1
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei434PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei569PhosphoserineCombined sources1
Cross-linki584Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei610PhosphothreonineCombined sources1
Cross-linki626Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki686Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5QJE6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5QJE6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5QJE6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5QJE6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5QJE6

PeptideAtlas

More...
PeptideAtlasi
Q5QJE6

PRoteomics IDEntifications database

More...
PRIDEi
Q5QJE6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63620

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5QJE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5QJE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher levels in testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000067334 Expressed in myocardium and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5QJE6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5QJE6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044502
HPA053707

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex.

Interacts with ESR1, ESR2, PPARG and RXRA.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119052, 35 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5QJE6

Protein interaction database and analysis system

More...
IntActi
Q5QJE6, 26 interactors

Molecular INTeraction database

More...
MINTi
Q5QJE6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000411010

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5QJE6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5QJE6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 605TdBR region; mediates interaction with DNTTAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili505 – 542Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3100 Eukaryota
ENOG410Z9Q4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018725_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5QJE6

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRSMQKK

Database of Orthologous Groups

More...
OrthoDBi
887634at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5QJE6

TreeFam database of animal gene trees

More...
TreeFami
TF105964

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039883 Fcf2/DNTTIP2
IPR014810 Fcf2_C

The PANTHER Classification System

More...
PANTHERi
PTHR21686 PTHR21686, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08698 Fcf2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5QJE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVTRSARAK ASIQAASAES SGQKSFAANG IQAHPESSTG SDARTTAESQ
60 70 80 90 100
TTGKQSLIPR TPKARKRKSR TTGSLPKGTE PSTDGETSEA ESNYSVSEHH
110 120 130 140 150
DTILRVTRRR QILIACSPVS SVRKKPKVTP TKESYTEEIV SEAESHVSGI
160 170 180 190 200
SRIVLPTEKT TGARRSKAKS LTDPSQESHT EAISDAETSS SDISFSGIAT
210 220 230 240 250
RRTRSMQRKL KAQTEKKDSK IVPGNEKQIV GTPVNSEDSD TRQTSHLQAR
260 270 280 290 300
SLSEINKPNF YNNDFDDDFS HRSSENILTV HEQANVESLK ETKQNCKDLD
310 320 330 340 350
EDANGITDEG KEINEKSSQL KNLSELQDTS LQQLVSQRHS TPQNKNAVSV
360 370 380 390 400
HSNLNSEAVM KSLTQTFATV EVGRWNNNKK SPIKASDLTK FGDCGGSDDE
410 420 430 440 450
EESTVISVSE DMNSEGNVDF ECDTKLYTSA PNTSQGKDNS VLLVLSSDES
460 470 480 490 500
QQSENSENEE DTLCFVENSG QRESLSGDTG SLSCDNALFV IDTTPGMSAD
510 520 530 540 550
KNFYLEEEDK ASEVAIEEEK EEEEDEKSEE DSSDHDENED EFSDEEDFLN
560 570 580 590 600
STKAKLLKLT SSSIDPGLSI KQLGGLYINF NADKLQSNKR TLTQIKEKKK
610 620 630 640 650
NELLQKAVIT PDFEKNHCVP PYSESKYQLQ KKRRKERQKT AGDGWFGMKA
660 670 680 690 700
PEMTNELKND LKALKMRASM DPKRFYKKND RDGFPKYFQI GTIVDNPADF
710 720 730 740 750
YHSRIPKKQR KRTIVEELLA DSEFRRYNRR KYSEIMAEKA ANAAGKKFRK

KKKFRN
Length:756
Mass (Da):84,469
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C58EFABA2B42E4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KP30J3KP30_HUMAN
Deoxynucleotidyltransferase termina...
DNTTIP2
601Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRB3E9PRB3_HUMAN
Deoxynucleotidyltransferase termina...
DNTTIP2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA50601 differs from that shown. Reason: Frameshift.Curated
The sequence AAH47688 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47A → D in AAQ95169 (PubMed:15047147).Curated1
Sequence conflicti47A → D in AAA50601 (Ref. 3) Curated1
Sequence conflicti67R → S in AAQ95169 (PubMed:15047147).Curated1
Sequence conflicti67R → S in AAA50601 (Ref. 3) Curated1
Sequence conflicti648M → I in BAD96442 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038748309E → D4 PublicationsCorresponds to variant dbSNP:rs3747965Ensembl.1
Natural variantiVAR_038749341T → A. Corresponds to variant dbSNP:rs3179879Ensembl.1
Natural variantiVAR_038750430A → V. Corresponds to variant dbSNP:rs35650636Ensembl.1
Natural variantiVAR_061710477G → E. Corresponds to variant dbSNP:rs41292661Ensembl.1
Natural variantiVAR_038751676Y → F. Corresponds to variant dbSNP:rs12748154Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046574 mRNA Translation: BAD08331.1
AY394925 mRNA Translation: AAQ95169.1
U15552 mRNA Translation: AAA50601.1 Frameshift.
AY336729 mRNA Translation: AAR02407.1
AK292379 mRNA Translation: BAF85068.1
AK222722 mRNA Translation: BAD96442.1
AL049796 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73064.1
BC047688 mRNA Translation: AAH47688.1 Sequence problems.
BC130622 mRNA Translation: AAI30623.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44174.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G01522

NCBI Reference Sequences

More...
RefSeqi
NP_055412.2, NM_014597.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000436063; ENSP00000411010; ENSG00000067334

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:30836

UCSC genome browser

More...
UCSCi
uc001dqf.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046574 mRNA Translation: BAD08331.1
AY394925 mRNA Translation: AAQ95169.1
U15552 mRNA Translation: AAA50601.1 Frameshift.
AY336729 mRNA Translation: AAR02407.1
AK292379 mRNA Translation: BAF85068.1
AK222722 mRNA Translation: BAD96442.1
AL049796 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73064.1
BC047688 mRNA Translation: AAH47688.1 Sequence problems.
BC130622 mRNA Translation: AAI30623.1
CCDSiCCDS44174.1
PIRiG01522
RefSeqiNP_055412.2, NM_014597.4

3D structure databases

SMRiQ5QJE6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119052, 35 interactors
CORUMiQ5QJE6
IntActiQ5QJE6, 26 interactors
MINTiQ5QJE6
STRINGi9606.ENSP00000411010

PTM databases

iPTMnetiQ5QJE6
PhosphoSitePlusiQ5QJE6

Polymorphism and mutation databases

BioMutaiDNTTIP2
DMDMi166987398

Proteomic databases

EPDiQ5QJE6
jPOSTiQ5QJE6
MassIVEiQ5QJE6
MaxQBiQ5QJE6
PaxDbiQ5QJE6
PeptideAtlasiQ5QJE6
PRIDEiQ5QJE6
ProteomicsDBi63620

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
30836

Genome annotation databases

EnsembliENST00000436063; ENSP00000411010; ENSG00000067334
GeneIDi30836
KEGGihsa:30836
UCSCiuc001dqf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
30836

GeneCards: human genes, protein and diseases

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GeneCardsi
DNTTIP2
HGNCiHGNC:24013 DNTTIP2
HPAiHPA044502
HPA053707
MIMi611199 gene
neXtProtiNX_Q5QJE6
OpenTargetsiENSG00000067334
PharmGKBiPA142671963

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3100 Eukaryota
ENOG410Z9Q4 LUCA
GeneTreeiENSGT00510000048142
HOGENOMiCLU_018725_0_0_1
InParanoidiQ5QJE6
OMAiTRSMQKK
OrthoDBi887634at2759
PhylomeDBiQ5QJE6
TreeFamiTF105964

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DNTTIP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DNTTIP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
30836
PharosiQ5QJE6 Tdark

Protein Ontology

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PROi
PR:Q5QJE6
RNActiQ5QJE6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000067334 Expressed in myocardium and 226 other tissues
ExpressionAtlasiQ5QJE6 baseline and differential
GenevisibleiQ5QJE6 HS

Family and domain databases

InterProiView protein in InterPro
IPR039883 Fcf2/DNTTIP2
IPR014810 Fcf2_C
PANTHERiPTHR21686 PTHR21686, 1 hit
PfamiView protein in Pfam
PF08698 Fcf2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDIF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5QJE6
Secondary accession number(s): Q12987
, Q53H59, Q5TFJ4, Q6TLI0, Q76MJ8, Q86WX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 26, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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