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Entry version 67 (31 Jul 2019)
Sequence version 1 (10 May 2005)
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Protein
Submitted name:

Retinoic acid induced 1

Gene

Rai1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Retinoic acid induced 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rai1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103291 Rai1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5QGZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5QGZ6 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1762 – 1885PHD-typeInterPro annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 39DisorderedSequence analysisAdd BLAST39
Regioni53 – 130DisorderedSequence analysisAdd BLAST78
Regioni143 – 248DisorderedSequence analysisAdd BLAST106
Regioni318 – 365DisorderedSequence analysisAdd BLAST48
Regioni446 – 505DisorderedSequence analysisAdd BLAST60
Regioni521 – 554DisorderedSequence analysisAdd BLAST34
Regioni639 – 698DisorderedSequence analysisAdd BLAST60
Regioni922 – 1296DisorderedSequence analysisAdd BLAST375
Regioni1322 – 1539DisorderedSequence analysisAdd BLAST218
Regioni1583 – 1614DisorderedSequence analysisAdd BLAST32
Regioni1720 – 1753DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 32PolarSequence analysisAdd BLAST20
Compositional biasi177 – 243PolarSequence analysisAdd BLAST67
Compositional biasi454 – 468PolarSequence analysisAdd BLAST15
Compositional biasi479 – 498PolarSequence analysisAdd BLAST20
Compositional biasi679 – 694PolarSequence analysisAdd BLAST16
Compositional biasi972 – 994PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1087 – 1112PolarSequence analysisAdd BLAST26
Compositional biasi1141 – 1155PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1258 – 1273Pro-richSequence analysisAdd BLAST16
Compositional biasi1483 – 1505PolarSequence analysisAdd BLAST23
Compositional biasi1596 – 1614PolarSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPTA Eukaryota
ENOG410Z8S8 LUCA

KEGG Orthology (KO)

More...
KOi
K19749

Database of Orthologous Groups

More...
OrthoDBi
98385at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5QGZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSFRERCGF HGKQQNYPQT SQETSRLENY RQPGQAGLSC DRQRLLAKDY
60 70 80 90 100
YSPQPYTGYE GGTGTPSGTV ATAAADKYHR GSKSLQGRPA FPSYVQDSSP
110 120 130 140 150
YPGRYSGEEG LQTWGGPQPP PPQPQPLPGA VSKYEENLMK KTVVPPPNRQ
160 170 180 190 200
YPEQGPQLPF RTHSLHVPPP QPQQPLAYPK LQRQKPQNDL ASPLPFPQGS
210 220 230 240 250
HFPQHSQSFP TSSTYAPTVQ GGGQGAHSYK SCTAPSAQPH DRPMSANANL
260 270 280 290 300
APGQRVQNLH AYQPGRLGYE QQQQALQGRH HTQETLHYQN LAKYQHYGQQ
310 320 330 340 350
GQGYCPPDTA VRTPEQYYQT FSPSSSHSPA RSVGRSPSYS STPSPLMPNL
360 370 380 390 400
ENFPYSQQPL STGAFPTGIT DHSHFMPLLN PSPTDAASSV DPQAGNCKPL
410 420 430 440 450
QKEKLPDNLL SEVSLQSLTA LTSQVENISN TVQQLLLSKA TMPQKKGVKN
460 470 480 490 500
LVSRTPEQHK SQHCSPEGSG YSAEPAGTPL SEPPSSTPQS THAEPQDTDY
510 520 530 540 550
LSGSEDPLER SFLYCSQARG SPARVNSNSK AKPESVSTCS VTSPDDMSTK
560 570 580 590 600
SDDSFQSLHS TLPLDSFSKF VAGERDCPRL LLSALAQEDL ASEILGLQEA
610 620 630 640 650
IVEKADKAWA EASSLPKDNG KPPFSLENHG ACLDTVAKTS WSQPGEPETL
660 670 680 690 700
PEPLQLDKGG STKDFSPGLF EDPSVAFATT DPKKTSSPLS FGTKPLLGTA
710 720 730 740 750
TPDPTTAAFD CFPDTPTASS VDGANPFAWP EENLGDACPR WGLHPGELTK
760 770 780 790 800
GLEQGAKASD GVGKADAHEA SACMGFQEDH AIGKPAAALS GDFKQQEAEG
810 820 830 840 850
VKEEVGGLLQ CPEVAKADQW LEESRHCCSS TDFGDLPLLP PPGRKEDLEA
860 870 880 890 900
EEEYSSLCEL LGSPEQRPSL QDPLSPKAPL MCTKEEAEEA LDTKAGWVSP
910 920 930 940 950
CHLSGEPAVL LGPSVGAQSK VQSWFESSLS HMKPGEEGPE MERAPGSSGT
960 970 980 990 1000
SQGSLAPKPN KPAVPEGPIA KKEPVPRGKS LRSRRVHRGL PEAEDSPCRV
1010 1020 1030 1040 1050
PALPKDLLLP ESCTGPPQGQ AEGAGAPGRG LSEGLPRMCT RSLTALSEPQ
1060 1070 1080 1090 1100
TPGPPGLTTT PTPPDKLGGK QRAAFKSGKR VGKPSPKAAS SPSNPAALPV
1110 1120 1130 1140 1150
ASDSSPMGSK TKEPDSPSMP GKDQRSMVLR SRTKPQQVFH AKRRRPSESR
1160 1170 1180 1190 1200
IPDCRATKKL PANNHLPTAF KVSSGPQKEG RMSQRVKVPK PGTGNKLSDR
1210 1220 1230 1240 1250
PLHTLKRKSA FMAPVPAKKR SLILRSNNGS GGDGREERAE SSPGLLRRMA
1260 1270 1280 1290 1300
SPQRARPRGS GEPPPPPPLE PPAACMGLST QSSLPSAVRT KVLPPRKGRG
1310 1320 1330 1340 1350
LKLEAIVQKI TSPGLKKLAC RVAGAPPGTP RSPALPERRP GGSPAGAEEG
1360 1370 1380 1390 1400
LGGMGQMLPA ASGADPLCRN PASRSLKGKL LNSKKLSSAA DCPKAEAFMS
1410 1420 1430 1440 1450
PETLPSLGTA RAPKKRSRKG RTGTLGPSKG PLEKRPCPGQ PLLLAPHDRA
1460 1470 1480 1490 1500
SSTQGGGEDN SSGGGKKPKT EELGPASQPP EGRPCQPQTR AQKQPGQASY
1510 1520 1530 1540 1550
SSYSKRKRLS RGRGKTAHAS PCKGRATRRR QQQVLPLDPA EPEIRLKYIS
1560 1570 1580 1590 1600
SCKRLRADSR TPAFSPFVRV EKRDAYTTIC TVVNSPGDEP KPHWKPSSSA
1610 1620 1630 1640 1650
ASSSTSSSSL EPAGASLTTF PGGSVLQQRP SLPLSSTMHL GPVVSKALST
1660 1670 1680 1690 1700
SCLVCCLCQN PANFKDLGDL CGPYYPEHCL PKKKPKLKEK ARLEGTLEEA
1710 1720 1730 1740 1750
SLPLERTLKG LECSASTTAA APTTATITTP TALGRLSRPD GPADPAKQGP
1760 1770 1780 1790 1800
LRTSARGLSR RLQSCYCCDG QGDGGEEVAQ ADKSRKHECS KEAPTEPGGD
1810 1820 1830 1840 1850
TQEHWVHEAC AVWTSGVYLV AGKLFGLQEA MKVAVDMPCT SCHEPGATIS
1860 1870 1880
CSYKGCIHTY HYPCANDTGC TFIEENFTLK CPKHKRLPL
Length:1,889
Mass (Da):201,529
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i843AC98539569A7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY548172 mRNA Translation: AAT28187.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032853.1, NM_001037764.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
19377

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19377

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548172 mRNA Translation: AAT28187.1
RefSeqiNP_001032853.1, NM_001037764.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ5QGZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19377
KEGGimmu:19377

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10743
MGIiMGI:103291 Rai1

Phylogenomic databases

eggNOGiENOG410IPTA Eukaryota
ENOG410Z8S8 LUCA
KOiK19749
OrthoDBi98385at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rai1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ5QGZ6 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR034732 EPHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5QGZ6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5QGZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 31, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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