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Entry version 103 (16 Oct 2019)
Sequence version 2 (21 Sep 2011)
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Protein

Receptor-transporting protein 3

Gene

Rtp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-381753 Olfactory Signaling Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-transporting protein 3
Alternative name(s):
Transmembrane protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rtp3
Synonyms:Tmem7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2446841 Rtp3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 453CytoplasmicSequence analysisAdd BLAST453
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei454 – 474HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001819941 – 474Receptor-transporting protein 3Add BLAST474

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5QGU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5QGU6

PRoteomics IDEntifications database

More...
PRIDEi
Q5QGU6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5QGU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5QGU6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5QGU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in the liver. Not detected in the olfactory epithelium.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066319 Expressed in 44 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5QGU6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5QGU6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TAS2R16.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081985

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH22 Eukaryota
ENOG4111X4F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162454

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000185211

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5QGU6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITCAHPP

Database of Orthologous Groups

More...
OrthoDBi
1504302at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333246

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026096 R-trans_p
IPR026691 RTP3
IPR027377 Znf-3CxxC

The PANTHER Classification System

More...
PANTHERi
PTHR14402 PTHR14402, 2 hits
PTHR14402:SF9 PTHR14402:SF9, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13695 zf-3CxxC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01328 zf-3CxxC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5QGU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEEDIGDTE QWRHVFQELM QEVKPWHKWT LIPDKNLLPN VLKPGWTQYQ
60 70 80 90 100
QKTFARFHCP SCSRSWASGR VLIVFHMRWC EKKAKGWVKM RVFAQRCNQC
110 120 130 140 150
PEPPFATPEV TWDNISRILN NLLFQILKKC YKEGFKQMGE IPLLGNTSLE
160 170 180 190 200
GPHDSSNCEA CLLGFCAQND LGQASKPPAP PLSPTSSKSA REPKVTVTCS
210 220 230 240 250
NISSSRPSSK VQMPQASKVN PQASNPTKND PKVSCTSKPP APPLSPTSLK
260 270 280 290 300
SAREPKVTVT CSNISSSRPS SKVQMPQASK VNPQTSNPTK NDPKISCTSK
310 320 330 340 350
PSTTPRLTIQ QLSVVSPPAP APTCVIQMPS PTPIDGSRAA DVAKENTRSK
360 370 380 390 400
TPKALLSSPL YVPPTSSYVP PTSSYVPPTS SYVPPTSSYV PPTSSSVIVP
410 420 430 440 450
ISSSWRLPEN TICQVERNSH IHPQSQSSCC GACCESWCEI FRYSCCEAAC
460 470
NCMSQSPLCC LAFLILFLLL WYLL
Length:474
Mass (Da):52,220
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFAC15CB3E6FF069
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFB1A0A0G2JFB1_MOUSE
Receptor-transporting protein 3
Rtp3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1Missing in CAD20986 (PubMed:12461651).Curated1
Sequence conflicti197V → A in CAD20986 (PubMed:12461651).Curated1
Sequence conflicti197V → A in AAT70672 (PubMed:15550249).Curated1
Sequence conflicti197V → A in AAI12904 (PubMed:15489334).Curated1
Sequence conflicti206R → Q in CAD20986 (PubMed:12461651).Curated1
Sequence conflicti206R → Q in AAT70672 (PubMed:15550249).Curated1
Sequence conflicti206R → Q in AAI12904 (PubMed:15489334).Curated1
Sequence conflicti219V → A in CAD20986 (PubMed:12461651).Curated1
Sequence conflicti219V → A in AAT70672 (PubMed:15550249).Curated1
Sequence conflicti219V → A in AAI12904 (PubMed:15489334).Curated1
Sequence conflicti269P → S in CAD20986 (PubMed:12461651).Curated1
Sequence conflicti269P → S in AAT70672 (PubMed:15550249).Curated1
Sequence conflicti269P → S in AAI12904 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ428064 mRNA Translation: CAD20986.1
AY562227 mRNA Translation: AAT70672.1
AC118727 Genomic DNA No translation available.
BC112903 mRNA Translation: AAI12904.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81087.1

NCBI Reference Sequences

More...
RefSeqi
NP_694740.2, NM_153100.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084922; ENSMUSP00000081985; ENSMUSG00000066319
ENSMUST00000199891; ENSMUSP00000143305; ENSMUSG00000066319

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
235636

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:235636

UCSC genome browser

More...
UCSCi
uc012hbo.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428064 mRNA Translation: CAD20986.1
AY562227 mRNA Translation: AAT70672.1
AC118727 Genomic DNA No translation available.
BC112903 mRNA Translation: AAI12904.1
CCDSiCCDS81087.1
RefSeqiNP_694740.2, NM_153100.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081985

PTM databases

iPTMnetiQ5QGU6
PhosphoSitePlusiQ5QGU6
SwissPalmiQ5QGU6

Proteomic databases

MaxQBiQ5QGU6
PaxDbiQ5QGU6
PRIDEiQ5QGU6

Genome annotation databases

EnsembliENSMUST00000084922; ENSMUSP00000081985; ENSMUSG00000066319
ENSMUST00000199891; ENSMUSP00000143305; ENSMUSG00000066319
GeneIDi235636
KEGGimmu:235636
UCSCiuc012hbo.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83597
MGIiMGI:2446841 Rtp3

Phylogenomic databases

eggNOGiENOG410IH22 Eukaryota
ENOG4111X4F LUCA
GeneTreeiENSGT00940000162454
HOGENOMiHOG000185211
InParanoidiQ5QGU6
OMAiITCAHPP
OrthoDBi1504302at2759
TreeFamiTF333246

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5QGU6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000066319 Expressed in 44 organ(s), highest expression level in liver
ExpressionAtlasiQ5QGU6 baseline and differential
GenevisibleiQ5QGU6 MM

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026691 RTP3
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 2 hits
PTHR14402:SF9 PTHR14402:SF9, 2 hits
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTP3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5QGU6
Secondary accession number(s): E9QP29, Q2KHT1, Q8VDC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: September 21, 2011
Last modified: October 16, 2019
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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