UniProtKB - Q5QD14 (TAAR5_MOUSE)
Protein
Trace amine-associated receptor 5
Gene
Taar5
Organism
Mus musculus (Mouse)
Status
Functioni
Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.2 Publications
Miscellaneous
Trimethylamine is a bacterial metabolite found in some animal odors, and is a repulsive odor associated with bad breath and spoiled food for most organisms, except for M.musculus, where it acts as an attractant (PubMed:16878137, PubMed:23177478).2 Publications
GO - Molecular functioni
- trace-amine receptor activity Source: GO_Central
- trimethylamine receptor activity Source: UniProtKB
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
- mating behavior Source: UniProtKB
- sensory perception of chemical stimulus Source: UniProtKB
- social behavior Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Behavior |
Enzyme and pathway databases
Reactomei | R-MMU-375280 Amine ligand-binding receptors R-MMU-418555 G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Trace amine-associated receptor 5Short name: TaR-5 Short name: Trace amine receptor 5 Short name: mTaar5 Alternative name(s): Trimethylamine receptor |
Gene namesi | Name:Taar5 Synonyms:Gm227 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685073 Taar5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 70 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 71 – 91 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 109 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 110 – 130 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 154 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 204 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 205 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 226 – 253 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 254 – 274 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 275 – 284 | ExtracellularSequence analysis | 10 | |
Transmembranei | 285 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 308 – 337 | CytoplasmicSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication
Chemistry databases
ChEMBLi | CHEMBL3784908 |
GuidetoPHARMACOLOGYi | 170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070155 | 1 – 337 | Trace amine-associated receptor 5Add BLAST | 337 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 192 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q5QD14 |
PRIDEi | Q5QD14 |
PTM databases
iPTMneti | Q5QD14 |
PhosphoSitePlusi | Q5QD14 |
Expressioni
Tissue specificityi
Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000069706 Expressed in 8 organ(s), highest expression level in utricle of membranous labyrinth |
ExpressionAtlasi | Q5QD14 differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161258 |
HOGENOMi | HOG000239243 |
HOVERGENi | HBG106962 |
InParanoidi | Q5QD14 |
KOi | K05051 |
OMAi | HCAICDP |
OrthoDBi | 913195at2759 |
PhylomeDBi | Q5QD14 |
TreeFami | TF343107 |
Family and domain databases
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR009132 TAAR_fam |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01830 TRACEAMINER |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5QD14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAVLLPGSG EQPTAFCYQV NGSCPRTVHP LAIQVVIYLA CAVGVLITVL
60 70 80 90 100
GNLFVVFAVS YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW
110 120 130 140 150
FFGDFLCRLH TYLDTLFCLT SIFHLCFISI DRHCAICDPL LYPSKFTVRT
160 170 180 190 200
ALRYIVAGWG IPAAYTAFFL YTDVVERALS QWLEEMPCVG SCQLLFNKFW
210 220 230 240 250
GWLNFPAFFV PCLIMISLYL KIFVVATRQA QQIRTLSQSL AGAVKRERKA
260 270 280 290 300
AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF ITPPLVFDIF IWFAYFNSAC
310 320 330
NPIIYVFSYR WFRKALKLLL SREIFSPRTP TVDLYHD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY702329 Genomic DNA Translation: AAV70139.1 |
CCDSi | CCDS23738.1 |
RefSeqi | NP_001009574.1, NM_001009574.1 |
UniGenei | Mm.377236 |
Genome annotation databases
Ensembli | ENSMUST00000092659; ENSMUSP00000090329; ENSMUSG00000069706 |
GeneIDi | 215854 |
KEGGi | mmu:215854 |
UCSCi | uc007eqh.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY702329 Genomic DNA Translation: AAV70139.1 |
CCDSi | CCDS23738.1 |
RefSeqi | NP_001009574.1, NM_001009574.1 |
UniGenei | Mm.377236 |
3D structure databases
ProteinModelPortali | Q5QD14 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000090329 |
Chemistry databases
ChEMBLi | CHEMBL3784908 |
GuidetoPHARMACOLOGYi | 170 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q5QD14 |
PhosphoSitePlusi | Q5QD14 |
Proteomic databases
PaxDbi | Q5QD14 |
PRIDEi | Q5QD14 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000092659; ENSMUSP00000090329; ENSMUSG00000069706 |
GeneIDi | 215854 |
KEGGi | mmu:215854 |
UCSCi | uc007eqh.1 mouse |
Organism-specific databases
CTDi | 9038 |
MGIi | MGI:2685073 Taar5 |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161258 |
HOGENOMi | HOG000239243 |
HOVERGENi | HBG106962 |
InParanoidi | Q5QD14 |
KOi | K05051 |
OMAi | HCAICDP |
OrthoDBi | 913195at2759 |
PhylomeDBi | Q5QD14 |
TreeFami | TF343107 |
Enzyme and pathway databases
Reactomei | R-MMU-375280 Amine ligand-binding receptors R-MMU-418555 G alpha (s) signalling events |
Miscellaneous databases
PROi | PR:Q5QD14 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000069706 Expressed in 8 organ(s), highest expression level in utricle of membranous labyrinth |
ExpressionAtlasi | Q5QD14 differential |
Family and domain databases
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR009132 TAAR_fam |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01830 TRACEAMINER |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TAAR5_MOUSE | |
Accessioni | Q5QD14Primary (citable) accession number: Q5QD14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | January 4, 2005 | |
Last modified: | February 13, 2019 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries