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UniProtKB - Q5PU93 (Q5PU93_DANRE)
Protein
Submitted name:
T-cell factor 7 isoform C
Gene
tcf7
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 237 – 305 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- beta-catenin binding Source: InterPro
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: GO_Central
- fin development Source: ZFIN
- pectoral fin development Source: ZFIN
- regulation of transcription by RNA polymerase II Source: ZFIN
- spinal cord dorsal/ventral patterning Source: ZFIN
- T cell receptor V(D)J recombination Source: InterPro
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Biological process | Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: T-cell factor 7 isoform CImported |
Gene namesi | Name:tcf7Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-050222-4, tcf7 |
Subcellular locationi
Nucleus
- beta-catenin-TCF complex Source: GO_Central
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 237 – 305 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 313 – 340 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 16 – 30 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the TCF/LEF family.ARBA annotation
Phylogenomic databases
OMAi | LLMHYPA |
OrthoDBi | 807716at2759 |
PhylomeDBi | Q5PU93 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR024940, TCF/LEF IPR028785, Tcf7 |
PANTHERi | PTHR10373, PTHR10373, 1 hit PTHR10373:SF33, PTHR10373:SF33, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5PU93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQLNGGGGD DLGANDEMIA FKDEGDHEEK IRESAFTESD LADLKSSLVS
60 70 80 90 100
ETEISQSPAV IRRGQQDEQR IYSDKREHLD DVPKHHDGGM YKAPYSGYPF
110 120 130 140 150
LMLPEPYLPN GPVSPPSNKV SVVQQGMHPL TPLLPYEHFN PSPTHMPTDG
160 170 180 190 200
GQKPGVHRHQ TQEISGFYSL PQGQITPSMN WFSHSLMLQS GMHPTGIPHP
210 220 230 240 250
AIVPPSGKQE HDQFDRSIYN KSHAEAKREK EPKKPVIKKP LNAFMLYMKE
260 270 280 290 300
MRAKVIAECT LKESAAINQI LGRRWHALTR EEQAKYYELA RKERQLHVQL
310 320 330 340 350
YPSWSARDNY VSALGKKKRR KRDKQQDSST GPGSPKKCRA RFGLNQQTDW
CGPCR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY825026 mRNA Translation: AAV84016.1 |
RefSeqi | NP_001012389.1, NM_001012389.1 |
Genome annotation databases
GeneIDi | 497649 |
KEGGi | dre:497649 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY825026 mRNA Translation: AAV84016.1 |
RefSeqi | NP_001012389.1, NM_001012389.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 497649 |
KEGGi | dre:497649 |
Organism-specific databases
CTDi | 6932 |
ZFINi | ZDB-GENE-050222-4, tcf7 |
Phylogenomic databases
OMAi | LLMHYPA |
OrthoDBi | 807716at2759 |
PhylomeDBi | Q5PU93 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR024940, TCF/LEF IPR028785, Tcf7 |
PANTHERi | PTHR10373, PTHR10373, 1 hit PTHR10373:SF33, PTHR10373:SF33, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5PU93_DANRE | |
Accessioni | Q5PU93Primary (citable) accession number: Q5PU93 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 4, 2005 |
Last sequence update: | January 4, 2005 | |
Last modified: | June 2, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |