UniProtKB - Q5PT55 (NTCP5_HUMAN)
Protein
Sodium/bile acid cotransporter 5
Gene
SLC10A5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- bile acid:sodium symporter activity Source: GO_Central
GO - Biological processi
- bile acid and bile salt transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q5PT55 |
Protein family/group databases
TCDBi | 2.A.28.1.6, the bile acid:na(+) symporter (bass) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/bile acid cotransporter 5Alternative name(s): Na(+)/bile acid cotransporter 5 Solute carrier family 10 member 5 |
Gene namesi | Name:SLC10A5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000253598.1 |
HGNCi | HGNC:22981, SLC10A5 |
MIMi | 618582, gene |
neXtProti | NX_Q5PT55 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 142 | ExtracellularSequence analysisAdd BLAST | 123 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 174 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 196 – 206 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 207 – 227 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 228 – 231 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 253 – 270 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 271 – 291 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 292 – 308 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 309 – 329 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 330 – 333 | ExtracellularSequence analysis | 4 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 367 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 368 – 388 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 389 – 397 | ExtracellularSequence analysis | 9 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 438 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000253598 |
PharmGKBi | PA134933839 |
Miscellaneous databases
Pharosi | Q5PT55, Tdark |
Polymorphism and mutation databases
BioMutai | SLC10A5 |
DMDMi | 74708105 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000263745 | 20 – 438 | Sodium/bile acid cotransporter 5Add BLAST | 419 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q5PT55 |
MassIVEi | Q5PT55 |
PaxDbi | Q5PT55 |
PeptideAtlasi | Q5PT55 |
PRIDEi | Q5PT55 |
ProteomicsDBi | 63604 |
PTM databases
GlyGeni | Q5PT55, 3 sites |
iPTMneti | Q5PT55 |
PhosphoSitePlusi | Q5PT55 |
Expressioni
Gene expression databases
Bgeei | ENSG00000253598, Expressed in liver and 99 other tissues |
Organism-specific databases
HPAi | ENSG00000253598, Tissue enhanced (brain, liver) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000428612 |
Miscellaneous databases
RNActi | Q5PT55, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_2_0_1 |
InParanoidi | Q5PT55 |
OMAi | PLWIFTL |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q5PT55 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030209, SLC10A5 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF29, PTHR10361:SF29, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5PT55-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY
60 70 80 90 100
ENKRPNSSHL FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV
110 120 130 140 150
TIQLWDSEGR QERLIEEIKN VKVKVLKQKD SLLQAPMHID RNILMLILPL
160 170 180 190 200
ILLNKCAFGC KIELQLFQTV WKRPLPVILG AVTQFFLMPF CGFLLSQIVA
210 220 230 240 250
LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC TSTLLALIMM
260 270 280 290 300
PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS
310 320 330 340 350
FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF
360 370 380 390 400
GYSFAKVCTL PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP
410 420 430
FTVAMCSGCE MLLIILVYKA KKRCIFFLQD KRKRNFLI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050230 | 287 | I → T. Corresponds to variant dbSNP:rs7012758Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY825924 mRNA Translation: AAV80707.1 AK095808 mRNA Translation: BAG53134.1 BC136625 mRNA Translation: AAI36626.1 BC136631 mRNA Translation: AAI36632.1 |
CCDSi | CCDS34915.1 |
RefSeqi | NP_001010893.1, NM_001010893.2 |
Genome annotation databases
Ensembli | ENST00000518568; ENSP00000428612; ENSG00000253598 |
GeneIDi | 347051 |
KEGGi | hsa:347051 |
UCSCi | uc011lfs.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY825924 mRNA Translation: AAV80707.1 AK095808 mRNA Translation: BAG53134.1 BC136625 mRNA Translation: AAI36626.1 BC136631 mRNA Translation: AAI36632.1 |
CCDSi | CCDS34915.1 |
RefSeqi | NP_001010893.1, NM_001010893.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000428612 |
Protein family/group databases
TCDBi | 2.A.28.1.6, the bile acid:na(+) symporter (bass) family |
PTM databases
GlyGeni | Q5PT55, 3 sites |
iPTMneti | Q5PT55 |
PhosphoSitePlusi | Q5PT55 |
Polymorphism and mutation databases
BioMutai | SLC10A5 |
DMDMi | 74708105 |
Proteomic databases
EPDi | Q5PT55 |
MassIVEi | Q5PT55 |
PaxDbi | Q5PT55 |
PeptideAtlasi | Q5PT55 |
PRIDEi | Q5PT55 |
ProteomicsDBi | 63604 |
Protocols and materials databases
Antibodypediai | 50193, 37 antibodies |
Genome annotation databases
Ensembli | ENST00000518568; ENSP00000428612; ENSG00000253598 |
GeneIDi | 347051 |
KEGGi | hsa:347051 |
UCSCi | uc011lfs.3, human |
Organism-specific databases
CTDi | 347051 |
EuPathDBi | HostDB:ENSG00000253598.1 |
GeneCardsi | SLC10A5 |
HGNCi | HGNC:22981, SLC10A5 |
HPAi | ENSG00000253598, Tissue enhanced (brain, liver) |
MIMi | 618582, gene |
neXtProti | NX_Q5PT55 |
OpenTargetsi | ENSG00000253598 |
PharmGKBi | PA134933839 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_2_0_1 |
InParanoidi | Q5PT55 |
OMAi | PLWIFTL |
OrthoDBi | 1148347at2759 |
PhylomeDBi | Q5PT55 |
TreeFami | TF315811 |
Enzyme and pathway databases
PathwayCommonsi | Q5PT55 |
Miscellaneous databases
BioGRID-ORCSi | 347051, 4 hits in 824 CRISPR screens |
ChiTaRSi | SLC10A5, human |
GenomeRNAii | 347051 |
Pharosi | Q5PT55, Tdark |
PROi | PR:Q5PT55 |
RNActi | Q5PT55, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000253598, Expressed in liver and 99 other tissues |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030209, SLC10A5 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF29, PTHR10361:SF29, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTCP5_HUMAN | |
Accessioni | Q5PT55Primary (citable) accession number: Q5PT55 Secondary accession number(s): B2RN26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | January 4, 2005 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations